Posted by admin on Jun 30, 2022 in |
A simple, sensitive, specific, precise, and accurate stability-indicating reverse phase liquid chromatographic method was developed to simultaneously determine Artemether and Lumefantrine in bulk drugs and pharmaceutical formulations. The chromatographic analysis was performed by Microsorb MV100-5 C-18 column (250 x 4.6mm, 5 µm), with a mobile phase consisting of buffer and acetonitrile in the ratio of 65:35v/v, orthophosphoric acid used as a buffer (pH 3.5), at a flow rate of 1 ml/min and eluents monitored at 254nm. The method was validated for linearity, accuracy, precision, robustness, and application for assay as per ICH guidelines. The retention times of Artemether and Lumefantrine were 2.67 and 4.62 min, respectively. The calibration curves of peak area versus concentration, which were linear from 530µg/ml for Artemether and 60-210µg/ml for Lumefantrine had a regression coefficient (r2) greater than 0.999 & precise (R.S.D. < 2.0%). The method had the requisite accuracy, precision, and robustness for simultaneous determination of Artemether and Lumefantrine in...
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Posted by admin on Jun 30, 2022 in |
Background: Patients’ drug administration errors are often promoted by poor drug knowledge resulting from inadequate oral or written information. Patients’ insufficient or wrong knowledge regarding the medication they use may vary and probably lead to the incorrect use of the latter, thus causing a decrease in its efficacy or other health problems. Patients’ knowledge enhances active participation in therapy, thus increasing adherence and ultimately leading to better treatment outcomes. The primary aim of this study was to assess the impact of patient medication counseling by comparing the levels of patient’s medication knowledge achieved by medication counseling in an outpatient clinic. Medication errors are at the forefront and common provision of modern healthcare and one of the many hazards of hospitalization. The problem is of multidisciplinary and multifactorial in nature. Medical errors are events that are considered as a threat to patient well-being that should not happen or recur. The medication error is not only clinically significant in many occasions; it has serious economic consequences like extended hospital stays, additional...
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Posted by admin on Jun 30, 2022 in |
Tetradentate Schiff bases are synthesized from o-phenylenediamine, 5-bromo Salicylaldehyde, and 3-Acetyl-6-methyl-pyran-2, 4-dione, and then its colored complexes of Sm (III) and Eu (III) are formed. The structure of ligand and complexes are characterized by elemental analysis, magnetic susceptibility, thermal analysis, X-ray diffraction, 1H-NMR, mass, IR, UV-visible spectra, and conductometry. TGA/DSC spectral and kinetic parameter of the complexes was studied eagerly. The x-ray diffraction data proposes Tetragonal crystal system for Sm (III) complexes and orthorhombic for Eu (III) complexes. The ligand and their metal complexes were subjected for antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas Aeruginosa using the agar cup-plate method, and antifungal activity was observed by poison plate method against Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum. The results obtained above are in good agreement with previous findings with respect to the comparative activity of the free ligand and its complexes. The result of an investigation of antimicrobial activity indicates that all the ligands show an inhibitory effect against all the...
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Posted by admin on Jun 30, 2022 in |
The study aimed to develop a novel gel loaded with nanosponges containing fucoidan extracted from Dictyota bartayresiana for arthritis treatment. Brown algae are rich in fucan, a group of sulfated polysaccharides with superior healing properties. Among the numerous fucoidan sources, a species, Dictyota bartayresiana, was selected from the family Dictyotaceae for arthritis screening. Many types of arthritis are characterized by inflammation, stiffness, redness, and pain. The protein denaturation method was used for the in vitro anti-arthritic study of ethanolic extract of Dictyota bartayresiana. Percentage inhibition of five series of concentrations ranging from 100 – 1000 µg/ml of test solution showed values of 51.86% w/w, 55.56% w/w, 59.26% w/w, 65.19% w/w, and 85.49% w/w concerning with the standard, respectively. A concentration of 1000 g/ml induced an effective percentage inhibition. Fucoidan’s beneficial properties guide the development of effective formulations. Fucoidan isolated from algae is formulated in the form of nanosponges using an emulsion solvent diffusion method and developed in gel-loaded nanosponges with the help of carbopol 940 polymer. Because of the nanosize...
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Posted by admin on Jun 30, 2022 in |
This work aims to evaluate the antimicrobial potential of ethanol, methanol, and water extracts of cherry (Prunus avium) and acetone extracts of quince (Cydonia oblonga), hexane & ethyl acetate extracts of Handh (Taraxacum officinale), acetone & methanol extracts of sustchal (Malva neglecta) of the selected minor fruits and vegetables of Indian Himalayan Region. Agar well diffusion method has been used to determine the antimicrobial activities and minimum inhibitory concentrations (MIC) of different plant extracts against Gram-positive (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and two strains of fungus (A. niger, A. flavus). The extracts exhibited both antibacterial and antifungal activities against tested microorganisms. The concentration increase of the extracts resulted in the increase of inhibition zone values resulting in the increase in the antimicrobial activities of the extracts. Both pulp and peel of Quince (Cydonia oblonga) exhibited significant antimicrobial activity. Acetone Quince (Cydonia oblonga) and Handh (Taraxacum officinale) extract showed significant antibacterial activity (P < 0.05) against all tested bacterial...
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