Posted by admin on Aug 31, 2022 in |
The purpose of the current research was to formulate and evaluate patient-friendly allopurinol solid dispersion based fast-dissolving tablets using a sublimation technique in order to accomplish rapid drug dissolution. In the present study, an effort was made to fasten the release of allopurinol from oral tablet dosage form by the conversion of the drug into solid dispersion form followed by further incorporation of allopurinol solid dispersions with superdisintegrants and camphor/ammonium bicarbonate as the subliming agents. The prepared fast-dissolving tablets of allopurinol solid dispersion were analyzed for pre-compression and post-compression parameters. Based on the results obtained for in-vitro drug release studies, it was observed that the formulation F8 showed a fast release profile of about 99.51% in 30 min and a disintegration time 40 sec in comparison with other formulations. The initial dissolution rate was 34.25% / 10 min for the best formulation, F8. FT-IR studies disclosed that there were no interactions between drugs and excipients. The current investigation revealed the potential for the rapid dissolution of allopurinol solid dispersion...
Read More
Posted by admin on Aug 31, 2022 in |
The aim of the research work was to determine and compare the efficacy and pharmacoeconomics of Atorvastatin and Rosuvastatin. The cohort, observational, and prospective studies were conducted at KMC multispeciality hospital, Trichy. The hyperlipidemic patient was treated with Atorvastain (10 mg) and Rosuvastatin (5 mg) every day over a period of six months. Contemplating the inclusion and exclusion criteria, 104 patients were selected for the study. From the selected 104 patients, 52 patients were treated with Atorvastatin (Group- A) and Rosuvastatin (Group- B). The therapeutic effect of both drugs was compared. The level of Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein (LDL), and High-density lipoprotein (HDL) were estimated. Rosuvastatin-treated patient’s reports showed a significant reduction in total cholesterol, triglyceride, and low-density lipid-protein, and increased the high-density lipoprotein during the therapy compared to Atorvastatin treated patient’s group. The results revealed that Rosuvastatin is more effective than Atorvastatin and Rosuvastain is cost effective than...
Read More
Posted by admin on Aug 31, 2022 in |
The present study aimed to determine the antioxidant potential of different solvent extracts of A. malabarica. Drug discovery from traditional medicinal herbs has played a significant role in the therapeutic management of cancer and, undoubtedly, most novel clinical applications of medicinal plants and its secondary metabolites and derivatives. The leaves extract showed various folklore and traditional applications in India. The polar and non-polar solvents extracts such as hexane chloroform, ethyl acetate, methanol, and aqueous were subjected to various in-vitro antioxidant assays such as DPPH, ABTS, Superoxide, Nitric oxide, Hydroxyl radical and Ferrous ion chelation, Butylated Hydroxy Toluene was used as a standard. The percentage of scavenging and chelation values for antioxidant were obtained and tabulated. Effective concentration (EC50) values are calculated using linear interpolation. The result clearly exhibited that the methanol leaves extract possesses more efficient antioxidant properties than the other extracts. This scavenging free radical capacity can be used as a good anti-oxidizing agent in various fields of medicine, the food industry...
Read More
Posted by admin on Aug 31, 2022 in |
Breast cancer continues to pose a serious hazard to women worldwide. (EGFR) was one of the first key targets for these new anticancer drugs to be discovered. Triple-negative breast cancer affects almost half of all women in the World. This study focused on the phytochemicals from a medicinal plant Clitoria ternatea; these medicinal plants possess more phytochemical compounds that effectively fight against cancer cells. The five compounds were selected and a molecular docking study was performed against EGFR protein. The Pharmacokinetics and ADMET properties of these ligands help identify the best hits. Myricetin exhibits the highest binding energy among these five ligand molecules and is the best ligand to inhibit EGFR protein. Hence, this compound may act as a promising agent for treating breast cancer. However, more in-vivo and in-vitro testing is needed to establish their safety and efficacy in this...
Read More
Posted by admin on Aug 31, 2022 in |
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospective comparative observational study carried out at the Department of Gastroenterology of tertiary care hospital. A total of 38 patients were allowed to participate in the study and randomized into two study groups, Group I and II. Each group consists of 19 patients. Patients in group I treated with UDCA. Group II patients treated with OCA. Results: The most common symptoms observed in the two study groups were nausea /vomiting followed by loss of appetite and abdominal pain. Both Group I and II patients showed significant improvement in their symptoms after treatment. The mean of liver function test (LFT) parameters was compared before and after treatment....
Read More
