Posted by admin on Sep 30, 2022 in |
Jasminum multiflorum and Jasminum mesnyi, the ornamental shrubs belonging to family Oleaceae are widely distributed throughout India. Despite their use in the essence industry for making perfumes, oils, and creams, these species are also used in the healing wounds and ulcers, constipation, flatulence, skin diseases, rheumatism, stomatitis, diabetes, stress, antiseptic, diuretics, and gastric disturbance. The present study is designed to establish the authenticity of both species by evaluating various standardization parameters. The stems of both species were collected and dried under shade. Freehand transverse sections were taken for microscopic examination. The standardization parameters such as Moisture content, Ash values, Extractive values, Heavy metal content, Aflatoxin content, Microbial infestation and, Pesticides residue have been determined as per WHO guidelines. Results showed the J. multiflorum stem was greenish-grey in color, cylindrical shaped, fragile and have aromatic odor. Microscopy showed the presence of glandular multicellular trichomes, epidermis, collenchyma, endodermis, medullary rays, vessels, xylem cells, parenchyma, fibre bundle and calcium oxalate crystals. The stem of J. mesnyi is yellowish-green in color the surface is smooth and...
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Posted by admin on Sep 30, 2022 in |
Sandhāna kalpanā (Fermentation process) is a unique procedure implemented in Ayurveda for the preparation of fermented alcoholic and acidic medicinal formulations. Sandhāna dravyās (fermenting agents) act as fermentation initiators in them. The commonly used Sandhāna dravyās are Dhātakipuṣpā (flowers of Woodfordia fruticosa), madhūkapuṣpā (flowers of Madhuka indica) and yeast. Almost in all Sandhāna dravyās, the presence of microflora plays a significant role in fermentation. In recent studies, it was proved that the dried flowers of Dhātaki and Madhūkapuṣpā have yeast colonies in it. Total aerobic microbial count testing of Tulasi puṣpā (Ocimum tenuiflorum – flowers) done in our study also revealed the presence of yeast. Objectives: To determine whether tulasi is having any fermenting activity with respect to the microbial, pharmaceutical and analytical matter. Methods: Total aerobic microbial count testing of fresh and dry flowers of Tulasi and dry flowers of Madhūka was performed. Pharmaceutico-comparative analytical study of 3 samples of Ariṣṭā (a fermented medicinal preparation) named Drākṣāriṣṭā prepared using them was also done. Results: Flowers of Tulasi (fresh...
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Posted by admin on Sep 30, 2022 in |
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis in various rat models such as normoglycemic rats and glucose-loaded rats, adrenaline-induced hyperglycemic rat models as well as alloxan-induced diabetic rats. The extract exerted a significant (P<0.05) hypoglycemic effect at a dose of 200mg/kg on normoglycemic rats for 5 hours. The extract improved glucose tolerance significantly (P<0.05) in comparison to the control (2 gm/kg p.o. glucose) group. The extract significantly (P<0.05) decreased blood glucose concentration in adrenaline (0.8 mg/kg, i.p) treated rats. The extract also significantly (P<0.05) lowered blood glucose levels in alloxan-induced rats. The antidiabetic property of leave extract was comparable to Glibenclamide (standard drug) 0.5 mg/kg p.o. dose. Therefore, this study, “Antidiabetic Potential of Hydroalcoholic Extract of Leaves...
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Posted by admin on Sep 30, 2022 in |
Purpose: Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes Methods: Agar well diffusion method was employed for this purpose. Results: Gel formulation of different concentrations of extract were formulated that is 2%, 4%, 6%, and 8%, respectively, and antibacterial activity of the gels was measured against the bacteria Staphylococcus aureus and Propionibacterium acnes. In this clindamycin gel was used as the standard for comparative analysis. From evaluation results, it was concluded that the formulation of 8% showed better antibacterial activity as compared to other formulated preparations. In addition to this, an evaluation of gel formulations was performed considering various parameters, which were pH, appearance, viscosity, spreadability and homogeneity and the result were calculated. Conclusion: The ethanol thorn’ extract of Bombax ceiba possesses good antibacterial properties against the Staphylococcus aureus and Propionibacterium acnes. It also contains various phytoconstituents, which may be helpful in various health-related...
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Posted by admin on Sep 30, 2022 in |
Transferosomes are a special liposome type consisting of phosphatidylcholine and an edge activator. Glimepiride is a second-generation sulphonylurea exerting its effects in patients with type II Diabetes. Glimepiride is hydrophobic in nature possess less solubility and permeability. The study aims to formulate, optimize and evaluate Glimepiride Transferosomal gel for antidiabetic activity in Rats. Glimepiride loaded Transferosomes were prepared using thin film hydration method and were optimized using factorial design (32) using Design-expert® software (Version 7.0.0, Stat-Ease Inc., Minneapolis, USA); different formulations (F1-F9) were prepared. Two different independent variables were used, which include: Amount of Soya lecithin (X1), Amount of tween 80 (X2), and the responses are Entrapment Efficiency (Y1), vesicle size (Y2). The optimized formulation of Glimepiride transferosomes was incorporated into a Carbopol 934 gel base and 1.5 % of Glimepiride transferosomal gel was prepared, which was evaluated for drug content, pH, spreadability, viscosity and in-vitro drug release. The prepared Glimepiride transferosomes had a maximum EE% was found to be (73.25 %), particle size was found to be (323...
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