Posted by admin on Aug 31, 2022 in |
The present study was carried out to evaluate the hypolipidemic and hypoglycemic effects of the plant Barleria cristata L. Phytochemical screening of crude powdered leaf extract of Barleria cristata L. revealed the presence of various bioactive phytoconstituents. An acute toxicity study of 50% hydroethanolic leaf extract of Barleria cristata L. reported that at all normal therapeutic doses, the test sample was safe for oral treatment. There was no significant change in the bodyweight of rats. Diabetes was induced in experimental rats by the intraperitonial injection of Alloxan. The 50% hydroethanolic extract of Barleria cristata L effectively lowered the blood glucose level in diabetic rats which was equal to glibenclamide treated rats. The plant extract treated HLD rats showed a dose related hypolipidemic activity. All the lipid components – TC, TG, LDL-C, VLDL-Cholesterol levels were reduced significantly, and HDL-C, protective cholesterol level was increased. The present study clearly indicated that 50% hydroethanolic extract of Barleria cristata L. leaf had produced a hypoglycemic and hypolipidemic effect on both diabetic and HLD...
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Posted by admin on Aug 31, 2022 in |
Phenol was used as a sole carbon source for the perchlorate biodegradation as reported for the first time. Isolated bacterial species Pseudoxanthomonas sp. isolated from a sewage sludge consortium was found to reduce perchlorate while taking phenol as electron acceptor. The growth and perchlorate degradation were analyzed in a batch system along with the degradation profile of phenol by the microbial culture. The effect of the co-pollutants (nitrate, chlorate, nitrate, phosphate) was also considered as part of the present study, where nitrate was found to be the most significant. Perchlorate was significantly removed by the culture involving subsequent phenol degradation in a continuous packed bed system anaerobically from synthetic...
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Posted by admin on Aug 31, 2022 in |
Telmisartan has a strong, nonpeptide antagonist with long-acting angiotensin II type-1 (AT 1) receptor to treat essential hypertension. It is classified as a BCS class II medication, meaning it has poor solubility and high permeability. Because of their capacity to minimise toxicity and change bioavailability, niosomes are becoming increasingly essential in medication delivery. Telmisartan-loaded niosomes were created by adjusting the span 60 and cholesterol ratios in a thin film hydration technique and then assessed for vesicles size, entrapment efficiency and drug release. Batch N6 fulfilled all the requirements and hence it was selected as an optimized formulation of noisome. This investigation supports the use as carriers for developed niosomes to enhance the administration of Telmisartan by oral...
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Posted by admin on Aug 31, 2022 in |
Objective: This study gives an overview of prescribing pattern of antibiotics in children in our tertiary care teaching hospital. Methods: It is a prospective observational study carried out on paediatric in-patients with a sample of 160 patients based on age, inclusion, and exclusion criteria for a period of 6 months. The patient’s data were collected using a patient case record form and the data analysis was done. Results: Out of 160 patients data that were collected, the results showed that the majority of gender which were admitted to the hospital were male children 89 (55.62%), and many were from the age group of early childhood (6-12 years) 64 (40.00%). Respiratory tract infections were the diagnosis most commonly analyzed; overall, 236 prescribed antibiotics, cephalosporins 121 (51.21%) were commonly evident, and parenteral 161 (68.22%) – route of administration was observed to be followed more than other routes. Conclusion: Antibiotic Resistance is a worrisome factor worldwide, challenging treatment regimens. Surgeons & Physicians worldwide find it difficult to cope with the increased resistance...
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Posted by admin on Aug 31, 2022 in |
In this research work, numerous molecules that have substituted triazole phthalazine derivatives were obtained using phthalic anhydride as a starting material. It was taken as starting material that gave reaction in the precence of different conditions with different substituted benzoyl chloride that yielded 6 chloro-3 substituted 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazine derivatives (I-V). These intermediates further reacted with substituted benzaldehyde and yielded 4-2-3-Substituted – 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazin-6-yl) substituted hydrazinyl derivatives (VI-X) which were further react with triethyl amine and acetyl chloride yields (XXI-XXX). The antidiabetic effect was investigated using oral glucose tolerance test in normal and non-insulin-dependent diabetes mellitus (NIDDM) in STZ-rat model. In this model Roziglitazone taken as a standard drug for this pharmacological...
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