Posted by admin on Jun 30, 2022 in |
To compare the effect of combined oral contraceptive (COC) and progesterone-only injectable contraceptive (PIC) on the inflammation, we recruited 47 female participants (16 to 43 years old) in 3 groups: control participants (n=10), COC users (n=16) and PIC users (n=21). Using ELISA and Latex agglutination methods, we measured the effect of hormonal contraceptives on the inflammatory blood biomarker, C-reactive protein (CRP). Data were collected from July 2019 to January 2020 from Rajshahi Medical College and Hospital. The users of both COC and PIC had higher levels of CRP (p<0.001), as compared to the controls, and COC users had higher levels as compared to PIC users (p<0.001). We also found a correlation between the CRP data of contraceptive users and some socio-demographic variables. The CRP values of different demographic variables in the Elisa method but not in the Latex method were significantly correlated (p<0.01). There was a significant association between the types of contraceptives used, as measured both Latex and Elisa methods. Our data suggested that limiting hormonal contraceptives can...
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Posted by admin on Jun 30, 2022 in |
Adenosine release is more apparent after seizures or in-vitro seizure-like activity and tissue adenosine level increases quickly after seizure commencement. These adenosine increases linked to seizures are reflections in composing a response mechanism that controls seizure intensity and duration. Much evidence from animal studies suggests that this impact is mediated by the adenosine receptor (AR), just as it is with neurotransmission in general. Efforts to produce centrally acting treatments and reduce peripheral side effects, especially cardiac adverse effects, have long been prioritized in drug development. New study is targeting highly precise areas of the A2R might be a step forward in direct A2R-based anti-seizure therapy. Despite significant attempts to introduce innovative tactics for the treatment of various kinds of epilepsy, this illness continues to be a serious problem across the globe. Taking inspiration from the facts above and recognizing the growing need for anti-epileptic compounds with improved pharmacodynamics and pharmacokinetic profiles in the worldwide market. The present in-silico research involves studying the anti-convulsant (anti-epileptic) potentials of some substituted 2′-(prop-1-en-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-diol...
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Posted by admin on Jun 30, 2022 in |
Alzheimer’s (AD) has been the most prevalent kind of dementia, generally producing linguistic and visuospatial deficits, frequently combining comfort ability problems such as apathy, aggression and depression, via the gradual deterioration of the episodic memory and learning. A noteworthy pathophysiological cause is the presence in the neuronal cytoplasm of extracellular plaque of insoluble ß-amyloid Peptide (Aβ) and neurofibrillary (NFT) tangles containing hyperphosphorylated tau protein (P-tau). Genetics could be linked to approximately 70% of the probability of development of AD. In the present study, the efficacy of ethanolic extract of Annona squamosa leaves (ASE) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at dose of 2.5 mg/kg, ASE was given in rat at a dose of 100 mg/kg body weight, 200 mg/kg body weight and 300 mg/kg body weight. Anti-Alzheimer activity was assessed by Morris water maze, Novel object recognition test and Y-maze. And by biochemical test like neurotransmitter Acetyl cholinesterase activity, catalase activity, malondialdehyde and Nitric oxide assays. Results showed that extracts treatment prevents Alzheimer and...
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Posted by admin on Jun 30, 2022 in |
The solid lipid nanoparticles are sub-micron colloidal carriers (50-100 nm) that are composed of physiological lipid dispersed in water or in aqueous surfactant solution. Nadolol-loaded SLNs were prepared by modified high shear homogenization. It was observed that all formulations contain a good product yield. The highest drug content was found in formulation F5 98.37%. Entrapment efficiency for formulation F5 (98.58 %) was maximum. F5 formulations have lowest particle size (151.76) and the lowest PDI value (0.12) good Zeta potential (-28.8). The dissolution data of Nadolol solid lipid Nanoparticles F5 formulation was shown maximum drug release at 30 min. i.e., 99.04%. Hence, F5 was concluded as an optimized formulation for solid lipid nanoparticles (Nadolol-loaded SLNs F5 formulation). The present work aimed at preparing oral film with a quick onset of action, which is very convenient for oral administration. Oral fast-dissolving films of Nadolol SLN were prepared using HPMC (E5) as film-forming polymer and PEG 400 as a plasticizer by solvent casting method. Dissolution of prepared oral films of Nadolol was...
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Posted by admin on Jun 30, 2022 in |
A simple, sensitive, specific, precise, and accurate stability-indicating reverse phase liquid chromatographic method was developed to simultaneously determine Artemether and Lumefantrine in bulk drugs and pharmaceutical formulations. The chromatographic analysis was performed by Microsorb MV100-5 C-18 column (250 x 4.6mm, 5 µm), with a mobile phase consisting of buffer and acetonitrile in the ratio of 65:35v/v, orthophosphoric acid used as a buffer (pH 3.5), at a flow rate of 1 ml/min and eluents monitored at 254nm. The method was validated for linearity, accuracy, precision, robustness, and application for assay as per ICH guidelines. The retention times of Artemether and Lumefantrine were 2.67 and 4.62 min, respectively. The calibration curves of peak area versus concentration, which were linear from 530µg/ml for Artemether and 60-210µg/ml for Lumefantrine had a regression coefficient (r2) greater than 0.999 & precise (R.S.D. < 2.0%). The method had the requisite accuracy, precision, and robustness for simultaneous determination of Artemether and Lumefantrine in...
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