Posted by admin on Apr 30, 2022 in |
The leaves and roots extracts of Clerodendrum infortunatum was evaluated for its potential antioxidant and antibacterial properties. The correlation studies with phytochemicals were performed, which has not been widely reported yet. Clerodendrum infortunatum leaves and roots were screened for the presence of phytochemicals and were found positive for carbohydrates, saponins, alkaloids, tannins, phytosterols, coumarin glycoside, cardiac glycoside, phenols, flavonoids, and terpenoids. The phenols were quantified using the Folin-Ciocalteu method. The phenolics were found to be highest in ethyl acetate leaf (63.83 mg GAE/g) and ethyl acetate root extracts (87.21 mg GAE/g) at a concentration of 500 µl. Flavonoids were quantified by aluminium chloride colorimetric method, and it was found highest in ethyl acetate leaf extract (244.16 mg QE/g) and hexane root extracts (38.83 mg QE/g) at 500 µl. Aqueous leaf extracts (0.99 g) and hexane root extracts (0.99 g) had the highest total terpenoid content. The antioxidant activity was evaluated using DPPH assay. Aqueous leaves extract and ethyl acetate root extracts exhibited higher DPPH radical scavenging activity with an...
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Posted by admin on Apr 30, 2022 in |
Gliclazide is an anti-diabetic medication used to treat diabetes mellitus type 2.It suffers from deprived solubility, reduced drug dissolution, and bioavailability. The current paper is aimed to formulate and evaluate gliclazide solid dispersion with HP β Cyclodextrin for enhanced solubility and incorporate into controlled-release tablet formulation. Gliclazide solid dispersion (SD) was prepared using varying ratios of HP β Cyclodextrin and evaluated. The optimized SD formulation was incorporated into the tablet by using hydroxypropyl cellulose and HPMC K 100M. The formulation SD 3 was chosen based on solubility and evaluation parameters, hence formulated into a controlled release matrix tablet formulation. Around 15 formulations of controlled release tablet blends evaluated for micrometric properties demonstrate that all the formulations posses good flow properties. The controlled release tablet formulation F15 with maximum drug content of 99.99% and drug dissolution of 99.96 % over 16h was chosen optimal and characterized. In-vivo bioavailability studies of optimized formulation (F15) and marketed products are performed on rabbits. The Cmax of the optimized formulation (132.56 ± 0.08ng/ml) was...
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Posted by admin on Mar 31, 2022 in |
Remogliflozin Etabonate (RE) is the latest addition to the sodium-glucose transport proteins 2 inhibitor class of drugs recently approved in India to manage type 2 Diabetes Mellitus. Literature survey revealed that no high-performance thin-layer chromatographic (HPTLC) method had been reported to date for this drug. The present work describes the development and validation of an HPTLC method for RE. The chromatography was performed on pre-coated silica gel 60 F 254 plates using methanol: toluene: ethyl acetate (1:4:5) v/v/v as mobile phase. A thin layer chromatographic (TLC) scanner set at 228 nm was used to directly evaluate the chromatograms in reflectance/absorbance mode. The drug was satisfactorily resolved with Rf 0.45. The method was validated according to the International Council on Harmonization (ICH) guidelines. The calibration plot was linear between 50–300 ng/b and respectively. The accuracy and precision of the proposed method were evaluated by recovery studies and intra-day and inter-day precision studies, respectively. In stability testing, RE was found to be susceptible to alkaline degradation. Because the method could effectively...
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Posted by admin on Mar 31, 2022 in |
A series of 1 – (4 -Benzhydryl piperazin-1-yl) -3-(mono -substituted) propan-1-one (7c-i) and N – (substituted) – 2 – (4 –benz-hydrylpiperazin – 1 – yl) acetamide (7a, 7d) were designed, synthesized and evaluated for their anticonvulsant and neurotoxicity activity. The chemical structure of the synthesized compounds was elucidated by spectral and elemental analysis. Compounds like 7d, 7c, and 7g showed good anticonvulsant activity and less neurotoxicity. Compounds 7a, 7c, 7f and 7l produce more neurotoxicity and also have less protection against convulsive stimuli than the other...
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Posted by admin on Mar 31, 2022 in |
Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel K4M, Methocel K15M & Xanthan gum were employed as polymers. All the formulations were prepared by direct compression method using 6mm flat punches. The blend of all the formulations showed a better angle of repose, bulk density, tapped density, compressibility index, and Hausner’s ratio. The prepared tablets exhibited excellent hardness, friability, drug content, buoyancy lag time, duration of buoyancy, swelling index. Among all the formulations, the F7 formulation floated for more than 12 h, showed short buoyancy lag time of 96±0.92 seconds, high swelling indices of 2.4±0.12 %, and showed maximum cumulative percent drug release of 98.21±0.24 % in 12 h. Consequently, formulation F7, made using xanthan gum in 10mg/unit...
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