Posted by admin on Jul 31, 2022 in |
For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity of 4-[(2-oxo-2-[5-(2-oxo-2H-chromen-3-yl)-1, 3-thiazol-2-yl] aminoethyl] amino] benzoic acid was comparable to that of ciprofloxacin and fluconazole. The reaming compounds had moderate to good...
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Posted by admin on Jul 31, 2022 in |
Diarrhea alters the movement of ions and water that follows an osmotic gradient and leads to Loose, watery stools, abdominal cramps, abdominal pain, fever, bloating, blood, and mucus in the stool. Numerous critical cases have been observed in both infants and adults. The main objective of this study is based on an exploration of risk factors of diarrheal infection caused in neonates by entering pathogenic Bactria. The enteric infections responsible for diarrhea are the major cause of morbidity and mortality worldwide, while 2–4 billion cases of diarrheal infections in infants occur worldwide every year. The major microbes associated with diarrheal infection belong to all the major groups, including viruses, bacteria and protozoans. Amongst various pathogenic factors, preferred bacterial pathogens have been considered as classical organisms for the study of diarrhea viz the strains of Escherichia coli for ion absorption mechanisms, Clostridium difficile and Shigella spp. as inflammatory diarrhea and Vibrio cholera for secretory diarrhea. The current study is focused on the members of Enterobacteriaceae, including the strain of E....
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Posted by admin on Jul 31, 2022 in |
To evaluate the rational drug use and efficacy evaluation of various combinations of Antihypertensive drugs commonly prescribed for the management of hypertension in CKD patients at tertiary care hospitals. This is an observational and comparative study. A randomized trial was carried out in 300 patients after obtaining the consent for 1 year in a tertiary care hospital in Mahabubnagar. The data collection form was prepared and used. This form mainly contains the patient’s demographic details and medication chart with diagnosis. Also, prescription pattern of the patient, daily usage of antihypertensive. Antihypertensive, antacids and anti-diabetics were the most prescribed drugs. A substantial number of drugs prescribed to patients with CKD were not appropriately adjusted. Inappropriate prescribing was associated with ADRS, and drug interactions. In the study, six antihypertensive combinations were observed in that CCB’s were the most frequently prescribed drug category in patients with HTN and...
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Posted by admin on Jul 31, 2022 in |
Background: Pain is a common symptom having huge public health importance. Conventional analgesics relieve pain effectively but cause various unwanted side effects. Hence the search for a novel analgesic with favourable risk-benefit profile is essential. Objectives: The current study was undertaken to investigate the analgesic activity of the ethanolic, hexane and chloroform extracts of sesame seeds by thermal heat method in Albino mice. Methods: The mice were divided into 5 groups. Group 1 was administered normal saline. Group 2 was given aspirin (50 mg/kg). Groups 3 to 5 were administered the various Sesame seed extracts (ethanolic, hexane and chloroform) at the doses of 100, 150 and 200 mg/kg, respectively. All drugs were administered orally. Analgesic activity was evaluated by hot plate method. Results: The ethanolic extract of Sesame seed at the dose of 100 mg/kg and 150 mg/kg exhibited significant analgesic activity at 120 and 180 minutes, whereas at a dose of 200 mg/kg it exhibited activity even at 60 minutes. The maximum analgesic effect was shown at 120...
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Posted by admin on Jul 31, 2022 in |
Background: Sepsis leads to approximately 11 million deaths annually. Objectives: We studied the effectiveness of using a combination of intravenous hydrocortisone (50mg QID), Ascorbic Acid (1.5g QID), and Thiamine (200mg BD) (HAT) to reduce mortality among septic patients compared to a historical control group. Materials and Methods: This retrospective, observational study was conducted between January 2016 – February 2018. Our hospital mortality for septic shock is 55%. According to published literature, hospital mortality decreased from 40.4% to 8.5% with the HAT protocol. To detect a 31.9% mortality difference with 95% confidence and 80% power, a minimum sample size of 27 patients would be required in each group. We included 62 patients (31 per group) with septic shock. In the experimental group, patients in septic shock received the HAT drugs within 6 hrs and continued for 4 days. They were compared with a propensity score-matched historical control group. Results: Nineteen (61.29%) and twenty-seven (87%) patients in the control group received steroid and vitamin supplements (non-Vitamin C), respectively. The mortality was...
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