Posted by admin on Apr 30, 2022 in |
In Benin, several studies still confirm the circulation of low-quality anti-malarial drugs, despite efforts to improve the supply chain. It is, therefore, necessary to carry out post-market quality surveillance of the same to ensure that only quality and efficacious medicines are sold to the general populace. The aim of this work was to evaluate the post-market quality of fixed-dose combinations of artemether-lumefantrine marketed in Benin. This descriptive and analytical study was executed in four stages over fourteen months, from December 2019 to January 2021. Thirty samples of artemether-lumefantrine (80/480 mg) fixed-dose combination tablets were collected from sixteen pharmacies in Cotonou and Porto Novo. The various quality control activities and tests conducted were: visual identification, pharmacopoeial tests (weight uniformity and disintegration tests), identification tests, in-vitro comparative dissolution tests and active ingredients content determination by HPLC-UV. The results of our analyses showed that none of the samples passed the visual identification test; all the samples passed the weight uniformity test in accordance with the specifications of the European pharmacopeia (Eur Ph)....
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Posted by admin on Apr 30, 2022 in |
Metformin, the first-line drug, can reduce hepatic gluconeogenesis and increase insulin sensitivity. At the molecular level, metformin inhibits the mitochondrial respiratory chain, which leads to an increase in adenosine monophosphate-activated protein kinase, which increases insulin sensitivity. Recent guidelines advocate metformin as the first-line agent that has a glucose-lowering effect concurrently with lifestyle modification. Metformin has long been shown to decrease vitamin B12 levels. Vitamin B12 is also an essential micronutrient required for optimal hemopoietic, neuro-cognitive, and cardiovascular function. Vitamin B12 deficiency has been highly prevalent among patients with type 2 diabetes mellitus. In this study, we want to figure out the association between metformin administration and VitB12 absorption defects in a diabetic patient pool on metformin alone and metformin with other combination drugs. Findings from this study indicate the role of metformin in vitB12 deficiency, uncontrolled glucose levels, and levels of serum Minerals in T2DM patients, gradually leading to microvascular and macrovascular complications even with one year of usage of...
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Posted by admin on Apr 30, 2022 in |
Embelin was one of active constituents of Embelia ribes Burm. f. Embelin has been reported to possess many pharmacological effects. The studies as was perform to enhance the bioavailability of poorly water soluble embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT. For this, phytosome, a novel drug delivery system, was adopted. Total six Embelin loaded phytosome complex formulations coded as EMBP1, EMBP2, EMBP3, EMBP4, EMBP5 and EMBP6 using soya lecithin and Chitosan in variable ratio were prepared by anti-solvent precipitation method and Rotary evaporation technique. The phytosome was characterized by parameters like percentage yield, particle size determination, entrapment efficiency, scanning electron microscopy (SEM), in-vitro release studies and establish drug release kinetic studies. Among six formulations, the Formulation EMBP5 well optimized. EMBP5 exhibits lowest 345.45 ±1.231 diameter. The entrapment efficiency of Embelin loaded phytosome complex varies from 64.99 ± 1.546 to 81.78 ± 1.151%. Embelin loaded phytosome complex formulation (EMBP5) exhibits highest of 81.78 ± 1.151% entrapment efficiency. SEM photomicrographs of optimized formulation (EMBP5)...
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Posted by admin on Apr 30, 2022 in |
With a view to enhancing endogenous knowledge about plants, the present study has been aimed at developing and standardizing dosage forms based on the aqueous extract of Morinda lucida Benth, a plant with hypoglycaemic anti-hyperglycaemic properties. After the aqueous extraction of the leaves of this plant, by maceration, phytochemical screening was carried out on a TLC plate by using the method of Wagner and Bladt (1996) then three capsule formulations were produced (F1, F2 and F3). Different pharmacotechnical tests were conducted according to the European Pharmacopoeia (Eur. Ph.). The presence of alkaloids, flavonoids and saponosids in the aqueous extract attests to its hypoglycaemic and anti-hyperglycaemic properties. Likewise, their presence in the capsules gives them these same properties and shows the neutrality of the used excipients on the phytochemical’s compounds of the extract. The average capsule masses are 190.525 mg, 250.04 mg, and 381.54 mg, respectively, for the formulas F1, F2, and F3 capsules. The polyphenols that were used as a tracker in the aqueous extract did not show a...
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Posted by admin on Apr 30, 2022 in |
Background and Objectives: A sper requisition of current regulatory requirements, a simple, rapid, and sensitive method by 33 factorial QbD approach was established and validated for Pioglitazone (PGZ) Glimepiride (GPR) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per International Conference for Harmonisation guidelines (Q2R1). Statistical data analysis was done for data obtained from different aliquots Runs on Agilent Tech. Gradient System with Autoinjector, UV (DAD) & Gradient Detector. Results: Equipped with Reverse Phase (Agilent) C18 column (4.6 mm × 100 mm; 2.5µm), a 20µl injection loop and UV730D Absorbance detector at 231nm wavelength and running chemstation 10.1 software and drugs along with degradants were separated via Methanol: (0.1% OPA) Water (70:30) of pH 3.2 as mobile phase setting flow rate 0.7 ml/min at ambient temperature. The developed method was found linear over the concentration range of 15-75 μg/ml for PGZ and 2-10 μg/ml for GPR, while detection and quantitation limit was found...
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