Posted by admin on Dec 31, 2021 in |
Objective: The objective was to study drug-drug interaction between Lornoxicam and oral hypoglycemic agents in normal and Streptozotocin-induced diabetes in rats. Material and Method: The protocol was blueprinted in two phases. In the first segment, the influence of Glibenclamide (0.7mg/kg/p.o.) and Glipizide (1.05mg/kg/p.o.) once daily on blood glucose levels in normoglycemic rats were studied and then the influence of Lornoxicam (1.64 mg/kg/p.o. once daily) pre-treatment on the hypoglycemic activity studied. Along with, the influence of Lornoxicam treatment for seven consecutive days (per se effect) on blood glucose levels was also studied in normoglycemic rats. In the second phase of the study, Streptozotocin-induced diabetic rats were used to assess the influence of Lornoxicam pre-treatment on Glibenclamide and Glipizide induced hypoglycemic effect in pathophysiological conditions. Blood samples were collected at accepted hiatus of 0.0, 0.5, 1.0, 2.0, 4.0, 8.0, 12.0, 18.0 and 24.0 h subsequent to drug treatment. All blood samples were evaluated for plasma glucose by the glucose oxidase peroxidase method (GOD/POD). Results: The findings suggested that Lornoxicam influences the hypoglycemic action of...
Read More
Posted by admin on Dec 31, 2021 in |
The aim of this study is to evaluate metformin and insulin effects on metabolic disorders and oxydatif stress markers, in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and recommend/or not a combination between metformin and insulin. Patients and Methods: We made this study on 120 subjects men divided into four groups (30 healthy control, 30 T2D without treatment, 30 T2D with metformin, and 30 T2D with insulin). Blood samples are collected for the determination of biochemical parameters (glucose, triglycerides, and cholesterol, high and low-density lipoprotein cholesterol) and oxidative markers (superoxide anion, nitric oxide, malondialdehyde, carbonyl proteins, oxygen radical absorbance capacity, vitamin C, catalase, glutathione). Results: Compared with healthy subjects, diabetic patients had altered lipid levels (cholesterol, triglycerides, LDL cholesterol) and high levels of pro-oxidant intra-cellular markers (O2•-, CP and MDA) associated to low concentrations of anti-oxidants (Vitamin C, catalase, and GSH). Our results show that insulin reduces more lipid parameters than metformin, moreover, the oxidant/antioxidant status became normal in patients...
Read More
Posted by admin on Dec 31, 2021 in |
For the last few centuries, the leaves of Stevia rebaudiana have been used as an efficient substitute for sugar due to its sweetness and almost negligible Glycemic effects. The study concentrates on the pharmacognostic aspects and other anatomical characteristics of the leaves. The study is performed on the plant leaves collected from the medicinal plant garden of Birla Institute of Technology, Mesra, Ranchi, India. The study is purely concentrated on finding various morphological characteristics and microscopic characteristics of the leaves. The microscopic characterization includes understanding the various anatomical characters of the leaves as well as the identification of the various diagnostic characteristics related to the leaves. Leaf constants, such as the Stomatal index, Stomatal number, Palisade ratio, vein-islet, and vein termination numbers, were also determined. The study also aims to determine various physicochemical parameters such as Moisture content, total ash, and extractive values. Preliminary phytochemical characterization of the aqueous extract of the leaves was also...
Read More
Posted by admin on Dec 31, 2021 in |
Hugonia mystax is a woody evergreen plant that grows in the dry forest areas of India and Sri Lanka. Often found in the forests of Kerala and Tamil Nadu in southern India. It is locally known as modirakanni (tamil) and kamsamaraha and tribals from Tamil Nadu, India, have used it in primary health care. The plant parts are used ethnobotanically to treat rheumatism, skin diseases and inflammations, snake bites, fever, and worm infestation. Hugonia mystax is an antibiotic, anthelmintic, febrifuge, astringent, peptic ulcer and verminosis remedy. Hugonia mystax has been practising herbal medicine for a long time. This plant is a member of the linaceae family and is an essential medicinal plant in Indian medicine. To evaluate the extractive values, powdered materials were subjected to successive extractions with ethanol using the Soxhlet process. The existence of several compounds such as flavonoids, phenolic elements, steroids, tannins, saponins, terpenoids, and carbohydrates was revealed by qualitative phytochemical screening of the ethanolic extracts of the leaves, as well as GC-MS analysis to examine...
Read More
Posted by admin on Dec 31, 2021 in |
Patients with psychotic disorders often require long-term and intensive treatment. Several drug utilization studies have been carried out using WHO (World Health Organization) prescribing indicators, but these studies are deficient for psychiatry patients in India. To analyze antipsychotic prescriptions according to WHO core prescribing indicators and identify various techniques used for switching over from one antipsychotic to another, a cross-sectional, observational study was conducted with one year and six months duration. 128 patients were enrolled who fulfilled the inclusion criteria and gave written informed consent. This study revealed male (53.91%) predominance over female patients (46.09%). The average number of drugs prescribed per encounter was 4.56. The percentage of drugs prescribed by generic name was 48.79%, and 52.06% of drugs were prescribed from the essential drug list. Atypical antipsychotics (53.28%) were prescribed more than typical antipsychotics (46.71%). 56.25% of patients were treated with monotherapy, and 43.75% patients were treated with polytherapy. Switching over of antipsychotics was seen in 33 (25.78%) patients. The most commonly used technique for switching was immediate/abrupt...
Read More
