Posted by admin on Mar 31, 2022 in |
A series of 1 – (4 -Benzhydryl piperazin-1-yl) -3-(mono -substituted) propan-1-one (7c-i) and N – (substituted) – 2 – (4 –benz-hydrylpiperazin – 1 – yl) acetamide (7a, 7d) were designed, synthesized and evaluated for their anticonvulsant and neurotoxicity activity. The chemical structure of the synthesized compounds was elucidated by spectral and elemental analysis. Compounds like 7d, 7c, and 7g showed good anticonvulsant activity and less neurotoxicity. Compounds 7a, 7c, 7f and 7l produce more neurotoxicity and also have less protection against convulsive stimuli than the other...
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Posted by admin on Mar 31, 2022 in |
Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel K4M, Methocel K15M & Xanthan gum were employed as polymers. All the formulations were prepared by direct compression method using 6mm flat punches. The blend of all the formulations showed a better angle of repose, bulk density, tapped density, compressibility index, and Hausner’s ratio. The prepared tablets exhibited excellent hardness, friability, drug content, buoyancy lag time, duration of buoyancy, swelling index. Among all the formulations, the F7 formulation floated for more than 12 h, showed short buoyancy lag time of 96±0.92 seconds, high swelling indices of 2.4±0.12 %, and showed maximum cumulative percent drug release of 98.21±0.24 % in 12 h. Consequently, formulation F7, made using xanthan gum in 10mg/unit...
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Posted by admin on Mar 31, 2022 in |
A chronic illness that affects a person’s mood, thoughts, physical health, and behavior patterns is considered depression. Currently used anti-depressant drugs such as selective serotonin reuptake inhibitors (SSRI) and tricyclic anti-depressants (TCA) are showing various side effects and thus, the search for a new anti-depressant herb without side effects is important. The intend of the present study was to evaluate the anti-depressant effect of methanol, chloroform and aqueous extract Acacia nilotica leaves at doses of 200 mg/kg in experimental animals. In-vivo screening models like Forced Swim Test (FST), Tail Suspension Test (TST) and Spontaneous Locomotor activity (SLMA) were used to assess the anti-depressant effects of the methanol, chloroform, and aqueous extracts of Acacia nilotica Linn. The dried-up leaves were subjected for shade drying and size reduced to powder and extracted by soxhlet apparatus. The extracts were subjected to phytochemical tests and the carbohydrate, tannins, alkaloids, flavonoids, saponins, glycosides and steroids were found to be present. Imipramine (30 mg/kg, i.p) was used as the reference standard, and it showed significant...
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Posted by admin on Mar 31, 2022 in |
The present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and lecithin. Pre-formulation studies for the pure drug were conducted, and formulations were evaluated based on viscosity, encapsulation efficiency and in-vitro drug release study using franz diffusion cell. FTIR study of pure drug-polymer and formulation proves there is no chemical interaction between them. Formulation SLN2 had appropriate viscosity of 1738.34, the highest encapsulation efficiency of 94.45%, drug loading 31.97%. SLN2 shows 95% cell viability. The in-vitro release study was found to have a zero-order release profile. Compared to all other formulations, this indicates the predominant mechanism of drug release is...
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Posted by admin on Mar 31, 2022 in |
Introduction: Most human oro-facial infections originate from odontogenic infections, and prescribing antimicrobial has become a ubiquitous phenomenon. The World Health Organization (WHO) has recognized the inappropriate, indiscriminate and irrational use of antimicrobials leading to antimicrobial resistance. Aim & Objective: To assess the knowledge of antimicrobial resistance and antimicrobial prescription among dental practitioners in Chennai city. Materials and Methods: A total of 110 registered dental practitioners participated in this cross-sectional study. A pre-validated and self-administered questionnaire was prepared and distributed to the registered dental practitioners in Chennai city to collect the demographic details and the information regarding knowledge and practice towards antimicrobial resistance and an antimicrobial prescription for the most common oral conditions and commonly prescribed antimicrobials for their patients were obtained. Statistical analysis. The data were statistically analyzed by using the Statistical Package for the Social Science version 20.0. Descriptive statistics were performed, and a Chi-square test was done to assess the association between knowledge and practice of BDS and MDS participants. Results: 79.66% of BDS and 92.16% of...
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