Posted by admin on Dec 31, 2021 in |
The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of one year in the ART center, where the ADR cases were recorded from the HIV patients suffering from tuberculosis. During the study, 135 patients co-infected with HIV and TB were analyzed from which a total 135 adverse drug reactions were collected and recorded. It is observed that rash, raised liver function, fever, peripheral neuropathy, and anaemia are the most common adverse drug reactions from the concomitant therapy of ART and ATT. From the study, 13 different types of ADRs were reported in patients on the ART and ATT therapy. It is important to do the causality assessment according to the WHO-UMC...
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Posted by admin on Dec 31, 2021 in |
The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus was recognized. Group A (n=80) was treated with vildagliptin (50 mg) with a combination of metformin (500 mg). Group B (n = 80) was treated with glimepiride (2 mg) with a combination of metformin (500 mg) with fixed dosage was given daily twice. The baseline of HbA1c from > 7.0% to <10.5%. The tests were performed by the help of vitros 250 and sysmex XN 1000 and 350. Thus, the performance of the t-test was found to play a significant role. Group A and group B have shown a greater reduction in plasma glucose fasting plasma glucose reduced up to 47.9mg/dl (p<0.000) in vildagliptin group versus glimepiride...
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Posted by admin on Dec 31, 2021 in |
Dental caries is considered one of the major oral health issues throughout the world. Synthetic drugs and antibiotics have major side effects and can develop resistance. Ficus benghalensis F. benghalensis is a plant with enormous established pharmaceutical properties. The present study was designed to evaluate the antimicrobial activity of water, and ethanolic extracts of F. Benghalensis leaves against human dental pathogens. The isolated dental pathogens are Streptococcus mutans, Lactobacillus, Klebsiella pneumonia, and Candida albicans. The cup plate method was used to evaluate the antimicrobial activity of water, and ethanolic extracts of F. benghalensis leaves against the isolated microbes. Data were analyzed in one-way variance analysis. The water extract of F. benghalensis leaves was active against Klebsiella pneumonia and Candida albicans. The ethanolic extract of F. benghalensis leaves was active against all the Streptococcus mutans, Lactobacillus, Klebsiella pneumonia and Candida albicans. Since both the water and ethanolic extracts of F. benghalensis leaves shows maximum antimicrobial activity against Klebsiella pneumonia with a diameter of inhibition zones 20 mm and 23 mm...
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Posted by admin on Dec 31, 2021 in |
The present study aimed to assess the role of angiotensin-converting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of treatment. Groups 5 to 8 were used to evaluate the antidepressant effect using forced swim test on days 1, 10, 20, and 30. Groups 9 to 12 were used to evaluate the effect on motor coordination using the Rotarod apparatus at 0, 30, 60, 90, 120 min. Statistical evaluation was done by ANOVA. P < 0.05 was considered statistically significant. Fall-off time was significantly earlier in only the standard group at 30 and 60 min. The period of immobility was lower in both the test groups on day 30. The total number of visits significantly decreased in both the test groups and standard groups on day 5. The...
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Posted by admin on Dec 31, 2021 in |
The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclamide (5 mg/kg/day). To determine fasting blood glucose, blood was drawn on days 1, 7, and 14, while it was drawn on day 14 for the determination of lipids, and relative body weight was measured at days 0 and 14. After 2 weeks of treatment, the fasting blood glucose levels of the MO-fed groups were significantly lower when compared with the diabetes mellitus (DM) group (P < 0.05), and the results were compared with standard Glibenclamide drug. Treatment with the MO also resulted in a significant decrease in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P< 0.05) accompanied by a significant increase in serum high-density lipoprotein cholesterol (P<...
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