Posted by admin on Jan 31, 2022 in |
This paper focused on research on seaweed contains good nutritional source of protein, carbohydrate, pigments, vitamins, and antioxidants and has low lipid content. The source of natural substances has considered more efficient bio-molecules in building immunity and improving resistance to cancer development, prevent infections were analyzed. Classical biochemical methods were applied for extraction of pigments and other related components from red algae; subsequently, quantities of each substance were determined and discussed its potential properties. Considerable attention has been focused on pigments-based biomaterials attributes antioxidant, antitumor, and immune-modulating properties due to their multi-functional qualities. The fresh solvent extracts of K. alvarezii was found to be rich in total anthocyanin 17 mg/g.f.wt content and vitamin C 21 mg/g.f.wt. Furthermore, the efficient combination treatment with anthocyanin plus vitamin C resulted in better therapeutic efficacy than carboplatin drug against Dalton’s lymphoma tumor. The tumor cell growth was arrested due to the administration of anthocyanin plus vitamin C (500µg/kg body wt. i.p) to tumor-bearing mice; thereby the efficiency of biomolecules was confirmed. The western...
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Posted by admin on Jan 31, 2022 in |
Green synthesis of copper oxide nanocrystals was carried out via hydroxide precipitation using rambutan peel wastes. The successful formation of copper oxide nanocrystals was confirmed by X-Ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM) analysis. XRD analysis confirms the calculated average crystallite size of higher intense plane peak (111) was 35.74 nm. SEM and TEM show the surface morphology and look flake-shaped. The AFM analysis shows needle formation of CuO nanoparticles. A possible mechanism for the formation of CuO nanocrystals with rambutan peel extract was also proposed. The prepared nanocrystals were coated on the cotton fabric, and their antibacterial activity was analyzed. Both CuO and CuO nanocrystals coated cotton fabric showed good antibacterial activity towards Escherichia coli E. coli and Staphylococcus aureus S. aureus. Wash durability test was carried out on the test fabrics showed that the significant antimicrobial activity was actively retained in the fabrics treated with CuO...
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Posted by admin on Jan 31, 2022 in |
Antioxidants are renowned protective molecules that are significant in the management of many chronic diseases. They can support the free radical mechanism to quench the cellular stress to prevent oxidative damage and improve existing therapy by playing a vital role in protection through antioxidant activities. The family Amaranthaceae is a well-known family for various health benefits. The selected plants Achyranthes aspera Linn and Chenopodium album Linn are also cited in the modern and traditional literature for their diversified health applications and pharmacological properties. So, the current work aims to screen the total phenolic, flavonoid, and saponin content of fractions made with solvents with various polarities and to screen their detailed antioxidant potential through DPPH assay, NO reducing assay, reducing power assay, and total antioxidant activity. It is inferred from the results that the methanol, chloroform, and aqueous fractions were rich in antioxidant components that are statistically significant with the reference...
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Posted by admin on Jan 31, 2022 in |
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug ibrutinib with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8). The effect of formulation parameters on practical yield and particle size were evaluated by L9 Taguchi orthogonal array design. The NS of highest solubilization extent for the drug were complexed with ibrutinib. Drug-loaded NS (IBNS) were characterized for various physicochemical properties. The optimized IBNS showed a particle size of 138 nm during a zeta potential of -21.6 mV. The drug loading capacity was 48%. More than 90% of the drug was released from IBNS2 over 24 h while that of free drug suspension was only 21%. The DSC, FT-IR, and PXRD studies confirmed the complexation of ibrutinib with NS and the amorphous state of the drug in the complex. Hence, the solubility and dissolution of the...
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Posted by admin on Jan 31, 2022 in |
Background: Dose appropriateness in Chronic Kidney Disease patients is crucial to avert toxicity since several drugs are eliminated through kidneys. The present study was taken up to identify the degree of appropriateness in the dosage regimen of patients with chronic kidney disease (CKD) patients. Methods: The study was a prospective observational study carried out in the Department of Nephrology in a tertiary care hospital of Telangana for 6 months. Patients diagnosed with CKD were included in the study, and the data regarding the demographic details, stage, prescribed drugs, etc., were obtained from the patients’ medical records. The creatinine clearance was estimated using Cockcroft Gault (CG) equation. The dose appropriateness was compared with the guidelines and published literature. Results: Out of 274 CKD Patients admitted, 200 were included in the study, amongst 35 % of the patients were in the age group of 61-75 years, followed by 41-60 years of age (33%). Almost 94.5% of patients were found to have co-morbid conditions with diabetes, hypertension and heart function disorders as...
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