Posted by admin on Nov 30, 2021 in |
This study was designed to evaluate the phytochemical findings for the presence of Alkaloids, Flavonoids, Phenols, and Terpenoids, and the phytochemical profile of chloroform and ethanol extracts of Panicum trypheron were analyzed using GC-MS (Gas Chromatography-Mass Spectrometry) method. The leaves were dried, powdered, and soaked in chloroform and ethanol, then subjected to GC-MS analysis by using Clarus 680 Gas chromatography. The unknown spectrum was compared with that of the known by using NIST (National Institute of Standards and Technology) database, which revealed the presence of different chemical entities in each of the extracts. The compounds are pharmacologically and biologically noteworthy. The extracts showed good antibacterial activity when tested against selected bacterial strains. This preliminary study gives an overview of the plant, which contains bioactive compounds and is therefore proposed as a pharmaceutically important...
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Posted by admin on Nov 30, 2021 in |
This study aims to valorizeten medicinal plants traditionally used for oral care in Benin by producing scientific data on their toxicities, antimicrobial activities, and chemical properties. The ten medicinal plants (Zanthoxylum zanthoxyloides, Vitellaria paradoxa, Prosopis africana, Dialium guineense, Pseudocedrela kotschyi, Parkia biglobosa, Azadirachta indica, Diospyros mespiliformis, Anogeissus leiocarpa and Bridelia ferruginea) were identified following an ethnobotanical survey conducted in Benin. With the exception of the hydroethanolic extract of Z. zanthoxyloides, all extracts have an LC50 greater than 0.1 mg/mL, indicating that these plants are non-cytotoxic. Of the ten extracts tested, only the hydroethanolic extract of Z. zanthoxyloides stem has no activity on the bacterial strains used. The results of the antibacterial test show that the largest diameter of inhibition was obtained in the extract of A. leiocarpa on Escherichia coli ATCC 25922, a reference strain with 25.67mm. The highest levels of total flavonoids (FVT) and total polypenols (TPP) are recorded respectively in P. kotschyi (145.86±0.7 EC/gMS) and D. guineense (70.194±0.220 EGA/g Ms). The antiradical powers of the extracts with...
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Posted by admin on Nov 30, 2021 in |
The study was designed to optimize cultural conditions for enhanced production of bioactive compounds by Streptomyces olivo-verticillatus VLK-15 isolated from mangrove ecosystem of South Coast of Andhra Pradesh, India. The soil dilution plate technique was employed for the isolation of actinobacteria using starch-casein agar (ISP-6) medium. The potent strain was identified as Streptomyces olivoverticillatus VLK-15 based on polyphasic taxonomy. The productivity of the strain was enhanced by amending the medium (ISP-2) with mannitol (0.5%), peptone (0.5%), and K2HPO4 (0.05%) adjusted to pH 7.0 and incubated with the culture at 30ºC for ninety-six hours. The secondary metabolites produced under optimized conditions exhibited high antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungi. Hence, it could be a possible source for novel and potential antimicrobial...
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Posted by admin on Nov 30, 2021 in |
Shyonak is botanically equated to Oroxylum indicum (L.) Kurz. of family Bignoniaceae. It is extensively used in the Indian system of medicine as an important ingredient of ‘Dashmoola and also one of the important constituents of a reputed Ayurvedic formulation ‘Chyavanprash’. The drug consists of root bark of Oroxylum indicum (L.) Kurz. Ayurvedic Pharmacopoeia of India (API) advocates that the stem bark can be used in case of the non-availability of the root bark. The root and stem bark is used for the treatments of diarrhoea, dysentery, erythema, gastralgia, hoarseness, infantile, measles, sore throat, urticaria, snake-bite and scorpion-sting. During the market survey it was found that the stembark of Ailanthus excelsa Roxb. (Family- Simarubaceae) is being sold in the name of Shyonak as an adulterant. Considering these points, an attempt has been made to identify and to establish quality standards for both root bark and stem bark of Shyonaka (Oroxylum indicum (L.) Kurz. along with stem bark of Ailanthus excelsa Roxb. HPTLC fingerprint profiles showed similar and differentiating bands....
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Posted by admin on Nov 30, 2021 in |
In an attempt of synthesizing some novel and potent antioxidant activity having compounds, here some novel quinoline derivatives are reported. Initially using Vilsemeir-Hack reagent method 7-methyl or 8-methyl substituted 2-cholro-3-formylquinolines (Ia, b) were prepared. Further 7-methyl or 8-methyl substituted 2-hydroxy quinoline-3-carbaldehyde (IIa, b) were synthesized by the reaction of compound (I) on microwave irradiation with 4M HCl, which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline III (a-f). Purity of the synthesized compounds was determined by TLC and melting point. The structure of all newly synthesized compounds was confirmed by spectral studies such as IR, 1H NMR, 13C NMR, and mass spectroscopy. All the synthesized compounds were screened for in-vitro antioxidant activity by free radical scavenging activity by DPPH assays method and ferric ion reduction method using ascorbic acid as the standard drug. Screening results showed that all compounds are exhibiting moderate to good activity. Especially compounds III b, III d, and III f showed significant antioxidant...
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