Posted by admin on Nov 30, 2021 in |
Gastric acid hypersecretion is a major cause of gastric complications like hypergastrinemia, hyperhistaminemia and Zollinger-Ellison syndrome. Out of various drug treatments used, H2-receptor antagonists possess some limitations, such as the development of tolerance when used for a long period, having a short duration of action, and no complete inhibition of acid secretion in response to a meal. In the case of PPIs they are showing the slow onset of action, short half-life, incomplete acid suppression, and differences in effectiveness in patients due to CYP2C19 (Cytochrome P2C19) metabolism To overcome these limitations, other alternative better therapeutic agents should be focused. Potassium-competitive acid blockers (P-CABs) or Acid pump antagonists (APAs) are new H+/K+-ATPase inhibitors that can exhibit almost complete inhibition of gastric acid secretion through reversible and K+-competitive inhibition of the enzyme. In our research work, We are reporting the synthetic methods of novel Quinazoline derivatives and their preliminary gastric acid secretion suppression action. Proposed compounds belong to two Series of N-((3-Benzamido-4-oxo-3, 4-dihydroquinazolin 2-yl) methyl)-N- (substituted) phenyl-benzamides and were prepared, and...
Read More
Posted by admin on Nov 30, 2021 in |
Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using the inclusion complexation technique with γ-CD as a complexing agent. Complexation is the association between two or more molecules to form a non-covalent-based complex that has a higher solubility than the drug itself. Binary mixtures of Candesartan cilexetil were prepared with three different techniques (Physical Mixture, Kneading method, Solvent evaporation method)in three different ratios (1:1, 1:2, 1:3). The prepared complexes were analyzed using Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed for all the prepared complexes by different methods in different ratios in order to define the most appropriate ratio and preparation...
Read More
Posted by admin on Nov 30, 2021 in |
Usage of medicinal plants for the treatment of various diseases had been started from 1500 BC onwards. Loss of cognition is one of the age-related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer’s. Various natural drugs are used for treatment of Alzheimer’s and Parkinsonism, but Available drugs provide symptomatic treatment with known side effects. So the present study is aimed to evaluate anti-amnesic activities of ethanolic flower extract of Ixora coccinea on mouse model as an attempt to search for new compounds against Alzheimer’s disease-related memory impairment. Ixora coccinea is a common flowering shrub native to Southern India and Sri Lanka. Traditionally it is used as hepatoprotective, antimicrobial, anti-oxidant, anti-nociceptive, anti-mitotic and anti-inflammatory activities. Decoction of roots was used for nausea, hiccups, and anorexia. Numerous activities were reported on the entire plant and various parts of the plant like root, leaf, and flower .The anti-amnesic activity was screened by the stair case method and elevated plus maze method. The staircase method has been widely used in...
Read More
Posted by admin on Nov 30, 2021 in |
Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the researchers to discover new phytochemicals with prominent and specific activity against different diseases. The objective of the present study was to evaluate the anti-cancer potential of dichloromethane extract of Mitragyna parvifolia stem bark using MTT assay and molecular docking studies. MTT assay was performed on MCF7, A549 and HepG2 cell lines. IC50 values were found to be 402.8 μg/ml, 207.4μg/ml and 104.4μg/ml, respectively. The phytoconstituents of extract were determined by GC-MS GC-MS analysis, most probable structures were identified and named using NIST library. GC-MS study revealed 76 compounds in which acontanes, decenes, and decanoicacids are of maximum percentage. A molecular docking study was conducted on the selected...
Read More
Posted by admin on Nov 30, 2021 in |
Periodontitis is a common infection occurring among a wide range of population globally. Streptococcus mutans is found to be the predominant pathogen responsible for dental caries. The present study concentrates on isolation and identification of the predominant pathogen from patients suffering from dental caries. The isolates were grown on various selective and differential media. Biochemical tests were performed to identify the pathogen. Further antibiogram assay was done to determine the sensitivity and resistance of the pathogen to several drugs. Aqueous, methanolic, and chloroform extracts of Azadirachta indica were prepared. The anti-bacterial efficacy and MIC of the extracts were evaluated. Samples were collected from 5 patients suffering from dental caries. From the morphological and biochemical observations, all the predominant isolates were found to be Streptococcus mutans. The isolates were sensitive to chloramphenicol, ciprofloxacin, Tetracycline, Gentamycin, and Methicillin. Resistance was observed for erythromycin, Penicilin, Vancomycin, Rifampicin, and cephalothin. Methanolic extracts (15 mm) showed higher inhibitory zones than the water (13 mm) and chloroform (11 mm). The MIC of the aqueous extract...
Read More
