Posted by admin on Oct 31, 2021 in |
Bombax ceiba L. is an important medicinal plant belonging to the family Bombacaceae. Root bark samples of the plant have been subjected to phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). Twenty phytochemical compounds have been identified in the methanolic extract of B. ceiba root bark. The identification of phytochemical compounds is based on the peak area, retention time, molecular weight and molecular...
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Posted by admin on Sep 30, 2021 in |
This study was aimed to evaluate the anti-diabetic activity of Ethanolic extract of the whole plant administered at different dosages (100 mg/kg and 200 mg/kg) for 21 days in Dithizone-induced diabetic rats using Glibenclamide as a standard drug (hypoglycemic drug). For the study, rats were divided into five groups of six animals each. Group, I served as control, Group II served as diabetic control received Dithizone, Group III diabetic rats were served with Glibenclamide while Group IV and V diabetic rats were received 100 mg/kg and 200 mg/kg of Ethanolic extract of Caralluma adscendens whole plant. The antidiabetic potential of the whole plant extract was undertaken in Dithizone induced hyperglycemic models by comparing biochemical parameters like blood glucose levels, OGTT and lipid profile (total cholesterol, triglycerides, LDL, and HDL), total protein and liver function tests (Total bilirubin, ASP, ALT, and AST) along with the liver antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA), glycogen content and Glycogenic enzymes were quantified using standard experimental procedures. ...
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Posted by admin on Sep 30, 2021 in |
The main goal of this work is to formulate nanosponges and access its suitability to deliver Luliconazole for topical application, to improve its therapeutic effect, better dispersion and good storage. Nanosponges are water-soluble, which does not mean that molecules are chemically decomposed in water but that nanosponge particles are mixed with water and used as a carrier fluid. Compared with traditional drug delivery methods, nanosponges have several advantages. Using polyvinyl alcohol as a surfactant, a nanosponge with ethyl cellulose as a polymer was prepared by the emulsion solvent diffusion method. An optimized batch of nanosponges with high entrapment efficiency was used to formulate the gel with Carbopol 940. The prepared gel was evaluated for pH value, viscosity, spreadability, in vitro diffusion study, skin irritation test and in-vitro antifungal activity. The nanosponge system is non-toxic, non-irritating, non-allergenic, and non-mutagenic. Nanosponge gel as a local drug delivery system has a huge potential, with better antifungal activity and stability. These small sponges loaded with luliconazole proved to be better scaffold for topical...
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Posted by admin on Sep 30, 2021 in |
Chronic low-grade inflammation of adipose tissue is associated with obesity and insulin resistance (IR). The aim of this study is to determine the effect of troxerutin (TX) on insulin signaling in tumor necrosis factor α (TNFα) treated 3T3-L1 adipocytes. Differentiated 3T3-L1 adipocytes were pre-treated with TX, elastatinal (ELAS) or sodium salicylate (SAL) before exposure to recombinant human TNFα (20 ng/mL) for 24 h. Glucose uptake was measured by 2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino]-2-deoxyglucose (2-NBDG) assay. The protein expression of insulin receptor-β (IR-β), insulin receptor substrate-1 (IRS-1), phosphatidyl inositol 3 kinase (PI3K) association with IRS-1, protein kinase B (Akt) and glucose transporter 4 (GLUT4) were studied. The mRNA and protein expression of caveolin-1 and suppressor of cytokine signaling 3 (SOCS3) were also analyzed. TNFα treated 3T3-L1 adipocytes displayed decreased tyrosine phosphorylation of IR-β and IRS-1. Further, the association of p85 subunit of PI3K with IRS-1, subsequent Akt phosphorylation and GLUT4 activation were also reduced. TX pre-treatment enhanced tyrosine phosphorylation of IR-β, IRS-1, IRS1-PI3K association and Akt and GLUT4 expression. These changes were...
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Posted by admin on Sep 30, 2021 in |
Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite and poor concentration with anxiety. Olanzapine is a second-generation antipsychotic (SGA) or atypical antipsychotic. It has attracted considerable interests due to its wide range of therapeutic and pharmacological properties and works in the brain to treat schizophrenia disorder, and may also be used in bipolar disorder and Schizophrenia. Fluoxetine is a class of selective serotonin reuptake inhibitors (SSRI) and works by blocking the absorption of the neurotransmitter serotonin in the brain. Regulating the amount of serotonin helps brain cells transmit messages to each other. This results in a better and more stable mood. For development and validation of Spectrophotometric Methods for Simultaneous estimation of Olanzapine and Fluoxetine from Bulk and Tablet Dosage Form was used Q-Absorbance Ratio method. Using the double beam instrument of Shimadzu –UV1900, as UV/Visible spectrophotometer method developed for simultaneous estimation of Q-Absorbance Ratio method. For the Q-Absorbance...
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