Posted by admin on Dec 31, 2021 in |
The present study aimed to assess the role of angiotensin-converting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of treatment. Groups 5 to 8 were used to evaluate the antidepressant effect using forced swim test on days 1, 10, 20, and 30. Groups 9 to 12 were used to evaluate the effect on motor coordination using the Rotarod apparatus at 0, 30, 60, 90, 120 min. Statistical evaluation was done by ANOVA. P < 0.05 was considered statistically significant. Fall-off time was significantly earlier in only the standard group at 30 and 60 min. The period of immobility was lower in both the test groups on day 30. The total number of visits significantly decreased in both the test groups and standard groups on day 5. The...
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Posted by admin on Dec 31, 2021 in |
The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclamide (5 mg/kg/day). To determine fasting blood glucose, blood was drawn on days 1, 7, and 14, while it was drawn on day 14 for the determination of lipids, and relative body weight was measured at days 0 and 14. After 2 weeks of treatment, the fasting blood glucose levels of the MO-fed groups were significantly lower when compared with the diabetes mellitus (DM) group (P < 0.05), and the results were compared with standard Glibenclamide drug. Treatment with the MO also resulted in a significant decrease in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P< 0.05) accompanied by a significant increase in serum high-density lipoprotein cholesterol (P<...
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Posted by admin on Dec 31, 2021 in |
The present study is focused on exploring the chemical components of the leaves, stem, root, and seeds of potential weed Digera arvensis. The plant has high nutritional value and therapeutic significance with prospective pharmacological activities. The various parts of the plants, i.e., leaves, stems, roots and seeds, were extracted using polar solvent ethanol. The preliminary phytochemical investigation of ethanoic extract of the plant parts showed the presence of primary and secondary metabolites like carbohydrates, reducing sugars, proteins, polyphenols, glycosides, alkaloids, tannins, flavonoids and terpenoids. The various spectroscopic methods reveal the presence of phytoconstituents, while the FTIR spectroscopic method was carried out on the ethanolic extracts of all the parts of Digera arvensis the confirming the presence of functional groups of the phytoconstituents. The FTIR analysis confirmed the presence of O-H, C-O, N-H, C-C, C-H, CO-O-CO and CH3 functional groups of the polyphenolic...
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Posted by admin on Dec 31, 2021 in |
This research was focused on the qualitative and quantitative analysis of phytochemicals and evaluation of in-vitro antioxidant and anti-inflammatory activities of three commonly used plant parts in rheumatoid arthritis medications in Ayurveda, namely, the root of Boehmeria nivea, the barks of Gmelina arborea and Oroxylum indicum, using standard methods. Qualitative analysis of each methanol extract confirmed the presence of alkaloids, flavonoids, condensed tannins, polyphenols, triterpenes, sterols, and saponins in varying quantities. The highest total alkaloid content of 108.81 ± 0.54 mg caffeine equivalent per 100 g of the dry weight of plant materials (DW) and the highest total flavonoid content of 268.94 ± 12.62 mg catechin equivalent per 100 g DW were exhibited by the bark extracts of Gmelina arborea and Oroxylum indicum, respectively. The highest total condensed tannin content of 529.34 ± 30.51 mg catechin equivalent per 100 g DW and the highest total phenolic content of 640.34 ± 64.58 mg gallic acid equivalent per 100 g DW were demonstrated by the root extract of Boehmeria nivea. The...
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Posted by admin on Dec 31, 2021 in |
In-silico studies play a very crucial role in medicinal chemistry and synthesis of the lead compound. As we know that 1,4-Dihydropyridine is a versatile molecule, and previous studies have shown that it possesses therapeutic activity in different diseases, such as anticancer, anticonvulsant, anticoagulant, anti-Alzheimer, antitubercular antiulcer. As described by the researchers, 1,4 Dihydropyridine with sulphanilamide substitution possess good antiulcer activity so, here, in our research work, we decided to synthesized 1,4 dihydropyridine derivative by replacement with some other free amine group-containing compound to determine the antiulcer property of 1,4 Dihydropyridine. To keep this in mind, we studied its interaction with receptor site (H+/K+ ATPase pump), which was obtained from protein data bank (PDB) and a series of 1,4-Dihydropyridine hybrid molecule synthesized. The binding of the molecule with receptor site investigated by molecular docking studies and drug-like illness of these compound predicted by using Schrodinger maestro suite 2018-4. Omeprazole and Lansoprazole were used as a standard to validate the docking results. Synthesized molecule characterized by spectroscopic methods and evaluated for...
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