Posted by admin on Oct 31, 2021 in |
The main objective of this study was to formulate a Sustained release tablet by wet granulation method. A sustained release tablet of trazadone hydrochloride was prepared by using synthetic polymer. The prepared tablets were evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of the tablet range from 5.43±0.288 to 5.76±0.05 and 09.68±0.577 to 10.04±0.04, respectively. Drug content was studied, and its ranges from 92.03 to 98.60%. Hardness was studied; its ranges 5.5 to 6.5 kg/cm2, Friability ranges 0.71 to 0.95%, Weight variation ranges between 434±1.49 to 460±1.23. FTIR and DSC analysis does not show any interaction of drug with Excipient. The formulation was optimized on the basis of acceptable pre and post-compression parameters. The results of dissolution studies indicated that Batch F4 containing eudragit RL 100 exhibited drug release of 88.06% at the end of 12 h to provide sufficient concentration for achieving satisfactory therapeutic value for an extended period of time. Optimized batch best fitted to Higuchi model. The n value...
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Posted by admin on Oct 31, 2021 in |
The present study aims to formulate and evaluate clopidogrel bisulfate capsule-loaded nanoparticles. Clopidogrel bisulfate nanoparticles were produced by the nano-precipitation method and emulsification solvent evaporation method using ethylcellulose polymer at different ratios and characterized for particle size drug entrapment efficiency dissolution testing scanning electron microscopy imaging (SEM) and compatibility studies (Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Optimized nanoparticles were filled into capsules with different concentrations of HPMC 4 KM and further evaluated. The prepared nanoparticles characterized and found to be the particle size was ranged from 100-2500 nm, and entrapment efficiency was ranged from 23.88 ± 0.20 % to 90.53 ± 0.31%. Amongst all formulations, F6 and F10 were considered for further optimization showed dissolution 53.20 ± 0.27 and 39.87 ± 0.12 % at the end of the first hour with entrapment efficiency 70% and 79%, respectively. SEM of clopidogrel bisulfate nanoparticles confirmed small particles without aggregation. The particle size of F6 and F10 obtained was 287.6 and 349.8 nm, respectively. Compatibility studies revealed that...
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Posted by admin on Oct 31, 2021 in |
Two monobasic bidentate ligands L1H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazine-carboxamide] and L2H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide] were synthesized by the condensation of [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene) with semicarbazide and thiosemcarbazide, which formed a series of complexes with cobalt(II) and nickel(II). The ligands and the metal complexes were characterized based on elemental analysis, IR, UV–Visible, 1HNMR, Mass spectroscopy. Spectral studies revealed that the ligands acted as monobasic bidentate, coordinating to the metal ion through the azomethine nitrogen i.e. >C=N and carbonyl oxygen atom of the isatin moiety. All the Schiff base metal complexes have a mononuclear structure, and the octahedral geometry has been proposed on the basis of spectral studies. The nickel (II) complex Ni (L2) (OAc).3H2O was subjected to XRD studies which revealed a monoclinic crystal system. In vitro, biological screening effects of the compounds were tested against two bacterial species Staphylococcus aureus and Escherichia coli. DNA cleavage and antioxidant activity of the ligands and their respective complexes were also...
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Posted by admin on Oct 31, 2021 in |
Datura (Datura metel Linn.) is a herbaceous leafy annual and short-lived plant of the Solanaceae family. It’s commonly known as Angel’s trumpet, Devils apple, Jimson weed, stinkweed, and Thorn apple. The traditional system of medicine enlightened the importance of Datura metel Linn. of its great medicinal value. The roots, leaves and flowering tops have been used in India for their narcotic and antispasmodic properties in the treatment of numerous ailments and conditions. The juice of fresh leaves is used to relieve the painful swellings. The seeds and root possess anti-diarrheal and are used to treat insanity and fever. All parts of Datura are poisonous in nature, and it’s mentioned under sthavara visha category by Ayurveda. In the present study, roots of Datura, which are less toxic compared to the other parts of the plant, were studied both in raw and purified form. AS the drug, in general, was considered poisonous, purification was done with Ayurveda procedure (Shodhana Samskara) to reduce the toxicity of the noxious drug for its chemical...
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Posted by admin on Oct 31, 2021 in |
This study is focused on evaluating the detrimental factors of drinking water and its relation to blood glucose level and anxiety status of non-stressed experimental rats. The study was conducted on 30 adult Wistar albino rats. The control group was treated with filtered water by reverse osmosis unit, and test 1, test 2, test 3, and test 4 groups were treated with well water from rural area 1, rural area 2, urban area 1, and pipeline water from urban area 2 respectively. Each week, body weight and fasting blood glucose (FBG) levels were measured. From the 11th week onwards, animals’ anxiety response was measured using an elevated plus maze (EPM). On the 80th day of the experiment, all the animals were sacrificed, and blood was collected, and the pancreas was removed for further investigations. On 9th week of the experiment, FBG level became 83 ± 3.89 mg/dL, 94.6 ± 10.05 mg/dL, 79.8 ± 2.54 mg/dL, 79.5 ± 4.51 mg/dL, 107 ± 6.14 mg/dL for control, test 1, test 2,...
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