Posted by admin on Nov 30, 2021 in |
A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the electrodes has been studied through scanning electron microscopy (SEM). These studies revealed that the oxidation of MIR is facilitated at f-MWCNTs/GCE. After optimization of analytical conditions employing this electrode at pH 10.5 of 0.04M carbonate buffer for MIR, the peak currents were found to be linearly with different concentrations in the range of 6.72 × 10-6 M to 3.74 × 10-4 M for MIR. The detection limits were obtained of 32.45 × 10-8 M and 9.45 × 10-7 M for MIR, using DP-AAdSV. The prepared modified electrode has several advantages, such as simple in preparation method, showed high sensitivity with very low detection limits, and gave excellent reproducibility. The proposed method was also employed for the determination of MIR in pharmaceutical formulations,...
Read More
Posted by admin on Nov 30, 2021 in |
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin layers and provides smoothness and hydration to the skin, which facilitates drug absorption. The transferosomal gel of ketoconazole was prepared with the aim to achieve higher diffusion through the skin for the treatment of acne with minimum or no side effects. The formulations were prepared by the reverse-phase evaporation method. Formulations were prepared by varying the ratio of soya lecithin and cholesterol by maintaining room...
Read More
Posted by admin on Nov 30, 2021 in |
The present work deals with the development and validation of a novel, robust, precise, and accurate UV-spectrophotometric method for the estimation of canagliflozin in bulk and formulation using the principle of Analytical Quality by Design (AQbD). A central composite design (CCD) was employed for initial parameter screening and method optimization. Different statistical parameters were evaluated to decide the appropriateness of experimental data. Canagliflozin shows an absorption maximum at 290 nm using methanol and water. Factor screening slit width and sampling interval were identified as critical method variables, which were further evaluated by a CCD. Design Expert (Version 12.0.6.0, Stat-Ease Inc., Minneapolis, MN USA) software was used for the method optimization and generation of design space Good linearity was obtained for canagliflozin in the range of 5-25 μg/mL with R2> 0.9989. The method was found to be accurate with good average % recovery. The developed method was validated as per ICH guidelines. Based on AQbD development of the Spectrophotometric method ensured that quality is built into the method. The method...
Read More
Posted by admin on Nov 30, 2021 in |
This study was designed to evaluate the phytochemical findings for the presence of Alkaloids, Flavonoids, Phenols, and Terpenoids, and the phytochemical profile of chloroform and ethanol extracts of Panicum trypheron were analyzed using GC-MS (Gas Chromatography-Mass Spectrometry) method. The leaves were dried, powdered, and soaked in chloroform and ethanol, then subjected to GC-MS analysis by using Clarus 680 Gas chromatography. The unknown spectrum was compared with that of the known by using NIST (National Institute of Standards and Technology) database, which revealed the presence of different chemical entities in each of the extracts. The compounds are pharmacologically and biologically noteworthy. The extracts showed good antibacterial activity when tested against selected bacterial strains. This preliminary study gives an overview of the plant, which contains bioactive compounds and is therefore proposed as a pharmaceutically important...
Read More
Posted by admin on Nov 30, 2021 in |
This study aims to valorizeten medicinal plants traditionally used for oral care in Benin by producing scientific data on their toxicities, antimicrobial activities, and chemical properties. The ten medicinal plants (Zanthoxylum zanthoxyloides, Vitellaria paradoxa, Prosopis africana, Dialium guineense, Pseudocedrela kotschyi, Parkia biglobosa, Azadirachta indica, Diospyros mespiliformis, Anogeissus leiocarpa and Bridelia ferruginea) were identified following an ethnobotanical survey conducted in Benin. With the exception of the hydroethanolic extract of Z. zanthoxyloides, all extracts have an LC50 greater than 0.1 mg/mL, indicating that these plants are non-cytotoxic. Of the ten extracts tested, only the hydroethanolic extract of Z. zanthoxyloides stem has no activity on the bacterial strains used. The results of the antibacterial test show that the largest diameter of inhibition was obtained in the extract of A. leiocarpa on Escherichia coli ATCC 25922, a reference strain with 25.67mm. The highest levels of total flavonoids (FVT) and total polypenols (TPP) are recorded respectively in P. kotschyi (145.86±0.7 EC/gMS) and D. guineense (70.194±0.220 EGA/g Ms). The antiradical powers of the extracts with...
Read More
