Posted by admin on Sep 30, 2021 in |
Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insoluble at pH higher than 5.0 and soluble lower than it. The coated granules were obtained by coating the paracetamol with the Eudragit® E100 polymer (20% w/w) in Hüttlin Oystar fluidized bed. The tablets were obtained by direct compression with 800 mg as average weight, and the formulations were differentiated by the used disintegrant: Pharmaburst® 500, Prosolv® ODT G2 or Starlac®. Characterization of the granules and afterward of the obtained tablets were carried out. All formulations reached average weight, hardness, friability, disintegration in accordance with the proposed specifications. The mean disintegration time of the tablets was 20 seconds. Taste masking was evaluated in-vitro from a dissolution method adapted from the 41st United States Pharmacopeia, where the...
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Posted by admin on Sep 30, 2021 in |
Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of HbA1c% with various hematological indices and to elucidate the possible changes in some hematological and lipid parameters in people with poor glucoregulation. A total of 76 patients of both gender with type 2 DM were included in the study after fulfilling the exclusion and inclusion criteria. Data from complete blood picture reports of the subjects were collected and documented. The collected data includes the values of HbA1c, some elements of complete blood picture, and lipid profile. The subjects were divided into two categories with HbA1c% ≤ 7 and HbA1c% > 7. All blood parameters under study except lymphocytes showed a significant mean increase in subjects with HbA1c%...
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Posted by admin on Sep 30, 2021 in |
Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) on standardized mouse models of Anxiety and depression. The dried Leaves and Root was macerated with methanol separately and administrated and discern the dose of 100 mgk g-1 p.o. and 200 mgkg-1 p.o. of Achyranthes bidentata methanolic extract of Leaves (ABMEL) and the dose of 100 mgkg-1 p.o and 200 mgkg-1 p.o. of Achyranthes bidentata methanolic extract of Root (ABMER) were employed in Elevated Plus Maze test (EPM) and Open field test (OFT) with 1 mgkg-1 i.p of Diazepam as a standard drug to assess the anxiolytic activity and Modified Forced Swim test (MFST) and Tail suspension test (TST) with 15 mgkg-1 i.p. of Imipramine as a standard drug to assess the anti-depressant activity in Swiss...
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Posted by admin on Aug 31, 2021 in |
Mesenchymal stem cells are a small number of undifferentiated cells located in various tissues of the body. They have the ability to self-renew and differentiate into lineages of mesenchymal origin. They serve as most promising candidates for various regenerative medicine and tissue engineering applications. Their use in various clinical applications depend on their proliferative capacity to expand cell population. One of the key challenge to expansion is decline in proliferation and differentiation capacity of cells isolated from older individuals. In the present study, we have compared cellular characteristics of bone marrow-derived mesenchymal stem cells isolated from young (4 – 6 weeks age) and old (60-64 weeks age) rats. The two rat groups were compared for proliferation kinetics, differentiation potential and senescence markers SA- βgal, reactive oxygen species (ROS), as well as expression ofP16INK4A, P21 and telomerase genes. A significant decrease in frequency, population doubling time, and cell yield associated with increase in age were observed. A decline in differentiation potential for osteogenic and chondrogenic lineages, and an enhancement in...
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Posted by admin on Aug 31, 2021 in |
Cyclea peltata (Lam), belonging to the family Menispermaceae, is a common plant in South India. It is mentioned in Ayurvedic classics by Rajapatha and is one of the important drugs used in Ayurveda therapeutics and is used widely in different formulations in medical practice. The quality control of crude herbal drugs and their bio constituents is paramount in justifying their acceptability. The crude drugs can be identified systematically on the basis of their morphological, histological, chemical, physical and biological studies. Phytochemical screening reported the presence of alkaloids, carbohydrates, glycosides, phyto sterols compounds and proteins and amino acids. The plant is widely used in the treatment of cough, fever, kidney disorder, urinary disorder and snake poisoning. The aim of the present study is to extract and isolation of bioactive compound (Thymol) from Cyclea peltate (Lam) Hook f. Thoms, the isolation and characterization analysis, included Thin Layer Chromatography, High-Performance Thin Layer Chromatography, GC-MS and Spectroscopy studies (IR, NMR and MASS). The presence of thymol in the ethanolic fraction revealed that the...
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