Posted by admin on Jul 31, 2021 in |
Previous studies investigated the host-derived salivary matrix metalloproteinases (MMPs) are responsible for dentin caries progression. The utilization of the MMP inhibitors can become a successful strategy to control dentin caries. In this study, we have tested twenty-four different medicinal plant leaf extracts against human salivary MMPs for investigation of inhibitors. Total phenolics were extracted in methanol, and their assessment was performed by Folin-ciocalteau assay. The presence of salivary MMP inhibitors in all plant leaf extracts was tested by using gelatin zymography. S. cumini leaf extract was found to be containing the highest total phenolics content. Leaf extracts of S. cumini, T. catappa and C. fistula exhibited strong inhibitor activity against salivary MMPs. Presence of inhibitor activity was found to be depending on the amount of phenolics concentration in extracts. The inhibition of salivary MMPs due to the binding action of phenolics with salivary proteins was concluded. As per the data of image J gel analysis software, T. catappa leaf exhibited prominent inhibitor activity as compared to other plants. The...
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Posted by admin on Jul 31, 2021 in |
Objective: To investigate the hepatoprotective activity of polyherbal formulation composed of extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium. Methods: The hepato-protective activity of the formulation and extracts were assessed on the basis of histopathological changes in the liver and estimation of SGOT, SGPT, SALP, serum bilirubin of carbon tetrachloride-induced hepato-toxic rats. Results: The result of the present studies strongly indicates that the hepatoprotective property of polyherbal formulation is evidenced by less damaged hepatocytes cells. Conclusion: Polyherbal formulation composed of aqueous extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium revealed significant hepatoprotective profile as compared to standard formulation...
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Posted by admin on Jul 31, 2021 in |
Introduction: The study was aimed at knowing the effect of mobile phone electromagnetic radiation (EMR) on fertility in Wistar Albino Rats and to assess the capability of polyphenolic rich Withania somnifera root extract in shielding rat testis against EMR-induced injuries. Methodology: One hundred and forty-four male Wistar Albino Rats were included in the study and grouped in to 4. Group I received a standard diet, Group II exposed to active mobile phone radiation of 2700 MHz fields for 3 hours/day, Group III exposed to 2700 MHz fields for 3 hours/day along with administration of 250 mg/kg aqueous extract of Withania somnifera root (Aq-Wsr) orally and Group IV received standard diet and 250 mg/kg Aq-Wsr during the experimental period of 180 days. Results: Group-II showed a significant decline in the sperm parameters and reduced in-vivo antioxidants. Group III revealed significant augmentation of sperm parameters and regulated the in vivo antioxidants. On microscopic examination, Group II showed irregular seminiferous tubules, atrophy of spermatogonial cells, hyper-cellularity, degenerated spermatozoa, and decreased number of...
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Posted by admin on Jul 31, 2021 in |
Drugs that have a proximal absorption window can be improved by the Gastro Retentive Drug Delivery System which provides continuously releasing the drug for a prolonged period of time as controlled delivery before it reaches its absorption site, thus ensuring its optimal bioavailability. The intend of this current work is to formulate a gastro retentive floating tablet of Venlafaxine hydrochloride by hot-melt extrusion method. The buoyancy of tablet leftovers for 24 hours in the stomach and in a controlled way the drug was released. In the present work, by using the direct compression method, various formulations were made, in which HPMC K15M, Guar gum, and Xanthan gum were included as swelling polymers, sodium bicarbonate as gas generating agent, and MCC as diluent, talc, and magnesium stearate used as glidant &lubricant respectively. By the UV spectroscopic and IR spectroscopic interpretation, the characterization of the drug was recognized. The hardness, friability, uniformity of weight, drug-polymer interaction, in-vitro floating studies, Swelling Index & in-vitro drug release studies were evaluated for all the...
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Posted by admin on Jul 31, 2021 in |
Nephrolithiasis or kidney stone disease is a disease characterized by the formation of crystals in the kidney. It is a disease that is found in many countries with high rates of recurrence and treatment costs. This study analyzes the effect of Breadfruit leaf extract on oxalate levels of CaOx stones deposited in the kidney and leukocyte differentiation in hyper oxaluric rats induced ethylene glycol. Experimental research with a -post-test with control design using 25 rats, which randomly divides into five groups, namely Normal, Ethylene Glycol, extract doses of 100, 200, and 400 mg/kg BW groups. The rat’s induced ethylene glycol 0.75% v/v for 28 days to initiate hyperoxaluria and the formation of CaOx stones. The treatment groups were given extracts from days 15 to 28. The data show tht the induction of ethylene glycol increases the levels of kidney oxalate (CaOx). Giving Breadfruit leaf extract 400 mg/kg BW can significantly reduce kidney oxalate (CaOx) levels and influence the total level of leukocytes. Leukocyte differentiation. The Breadfruit leaf extract prevents...
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