Posted by admin on Aug 31, 2021 in |
Exposure to heavy metals may modify fish behavior, metabolism, physiology, growth, and reproduction. They are also responsible for introducing genetic and teratogenic effects in fish. Now a day’s in many regions; fish production is decreased due to the occurrence of diseases caused by different pathogens in aquaculture. The increasing level of trace elements is dangerous for fish growth and reproduction and for human beings. Rapid industrialization is contaminating natural freshwater by heavy metals (Fe, Zn, Co, Pb, Ni, Cr and Mn), turning it into a global problem. The effect of pollution on the aquatic ecosystem of river Ganga was monitored, and a field study was conducted by analyzing the different biomarkers enzymes. Biochemical parameters in the various tissues (muscles, liver, gills, and kidney) of the Indian carp Cirrhinusreba collected from the river Ganga from different study sites of Kanpur. The catalase peroxides, hydrogen peroxides, and protein content level significantly increased as compared upstream to downstream. The catalase activity in the tissue of carp fish was found to be significantly...
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Posted by admin on Aug 31, 2021 in |
The earlier reports on Nardostachys jatamansi show contain a various class of chemical constituents that have influenced the anti-inflammatory and anti-candidal activities. The present study reports the evaluation of anti-inflammatory and anti-candidal activities of N. jatamansi and also studies pharmacokinetic properties using in-silico model. In ongoing research work, we used individual extracts of dichloromethane, ethyl acetate, methanol, and water were prepared. The anti-inflammatory activity of different solvent extracts was carried out using gelatin zymography through detection of MMP-2 and MMP-9 and on other side anti-candidal activity was carried out using Nitro blue tetrazolium assay (NBT). Bioactivity and pharmacokinetic parameters of all extracts were calculated using the property calculation online toolkit. From the results, it is observed that, among all the tested extracts, ethyl acetate extract was found to be more potent towards phagocytosis (more than 5 MPN) and Candida albicans (41%) at 100 µg/mL while dichloromethane extract possesses profound anti-inflammatory activity towards MMP-2 (90%) and MMP-9 (85%) as compared to standardtetracyline HCl (positive control) followed by other extracts. Desoxo-Narchinol...
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Posted by admin on Aug 31, 2021 in |
Pashanabheda is used as antiurolithiatic in Ayurveda. In the present study, Punica granatum is used for screening in-vitro antiurolithiatic potentials. Screening of in-vitro antiurolithiatic potentials of aqueous leaf extract of Punica granatum. The extract was subjected to Preliminary phytochemical analysis. In-vitro anti-urolithiatic activity was screened by nucleation and aggregation assay in which the formation and growth of CaOx crystals were quantified. The extract exhibited inhibitory action in both nucleation and aggregation assays to a significant level. In the aggregation assay gradual decrease in the CaOx crystal nucleation, as well as growth, was observed by light microscopy. The findings of the nucleation assay indicate that the extract inhibited the crystallization of CaOx in the solution. There were less and smaller particles with increasing concentration of the extract. The increasing concentrations of extract (100, 200, 300, 400 and 500 µg/ml) inhibited the CaOx crystal growth. Punica granatum extract demonstrated slightly better results compared to Cystone standard solution to inhibit the formation of calcium oxalate dihydrate crystals in the nucleation assay. The...
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Posted by admin on Aug 31, 2021 in |
Anisomeles species are traditionally used for treating aliments like hysteria, amentia, dyspepsia, epilepsy, anorexia, diarrhoea etc. the present work, we aimed to evaluate the anti-diabetic activity and hepatoprotective activities of aqueous and ethanolic extracts of Anisomeles malabarica roots. Anti-diabetic activity was studied at three dose levels 100, 200, 400 mg/kg of aqueous and ethanolic extracts in normoglycemic and Streptozotocin (STZ) induced diabetic rat models. Tolbutamide (40 mg/kg) was used as standard treatment. Blood glucose levels were monitored at 1, 2, 4, 8, 16 and 24 h post-administration using glucometer. The hepatoprotective activity of the extracts was assessed at dose levels 100, 200, 400 mg/kg of aqueous and ethanolic extracts in ethanol intoxicated groups. Silymarin (100 mg/kg) was used as Levels of ALT, AST, ALP, and Bilirubin were measured using standard kits. Liver volumes and liver weights of the animals were also recorded. The results revealed that both aqueous and ethanolic extracts have anti-diabetic and hepatoprotective activities; however, the activity was more prominent with 400 mg/kg of ethanolic extracts and...
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Posted by admin on Aug 31, 2021 in |
Most of the Bio-medical wastes got dumped in highly eminent aquatic sources. To control this pollution due to biomedical wastes, the current study focused on the development of hydrogel bead nanocomposite incorporated with the adsorbent and nanoparticles along with biopolymer. The formed hydrogel bead nanocomposite acts as an effective adsorbent of infectious microbes, heavy metals and pollution causing materials. The conjugation efficiency of the activated tea dust, zinc oxide nanoparticles, and bioconjugated system was analyzed using UV-Vis spectroscopy which shows the maximum absorption at 330nm, 379nm, and 580nm in the conjugation system. Further, this was analyzed using FTIR shows good functional groups stretching, Dynamic Light Scattering analysis depicts the particle size as 5.203µm and has good stability. The effectiveness of the hydrogel bead nanocomposite on the wastewater sample was characterized through solubility test and heavy metal adsorption ability. The bead does not solubilize in the water sample over a long time which shows the high stability of the conjugated system. Whereas the adsorption efficiency (%R) of the hydrogel bead...
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