Posted by admin on Sep 30, 2021 in |
Aim: The present study focuses on studying the soft rot-causing bacteria in Solanum tuberosum and the activity of phytoextracts against the pathogen to prevent/control this infection. Lantana camara and Clerodendrum infortunatum has been well known for their antibacterial activity and widely used in Ayurveda, these plants were investigated for their antibacterial activity against the isolated pathogen. Methods: The bacteria were isolated from the infected potato sample and cultured in Potato dextrose agar (PDA) media. The isolated was characterized using morphological/biochemical properties and 16S rDNA sequencing. The pathogen was subjected to agar well diffusion assay to investigate antibacterial potential of L. camara and C. infortunatum extracts against this pathogen. Results: A gram-negative cocci were isolated from the infected S. tuberosum sample. Phylogenetic analysis using 16S rDNA sequencing, suggested no previous reports of such bacteria causing soft rot of potato. The 16S rDNA sequence was submitted to GenBank with accession ID MT491092. Phytoextracts of L. camara demonstrated significant antibacterial activity against the isolated bacterial strain SJCTSSP01. Prominent results were observed from...
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Posted by admin on Sep 30, 2021 in |
Cow urine is considered a Sanjeevani–a medicine capable of curing any disease according to ancient manuscripts from Vedic times. The present study was conducted to validate the medicinal properties of cow urine in a scientific manner. The cow urine sample was procured from Indian indigenous cow Bos indicus from Bombay Panjrapole, Bhuleshwar, Mumbai, and commercial gaumutra from the local market. Various treatments were given to the freshly collected cow urine viz. Photoactivated urine (PA), Cow urine distillate (DIS) and Crude cow urine sample (CRU) was used after filtration and centrifugation. In-vitro assays for antimicrobial (agar cup method), antioxidant (DPPH assay), anti-hyperglycemic (α-amylase inhibition) and anti-inflammatory (protein denaturation inhibition bioassay) properties of cow urine were carried out. Results confirmed antimicrobial (19 mm zone of clearance), antioxidant (157 µg /ml), anti-hyperglycemic (2.08 µg /ml) and anti inflammatory (23.72µg /ml) and comparable to Chloramphenicol, Ascorbic acid, Acarbose, and Ibuprofen used as standard respectively. The study demonstrates various medicinal properties of cow urine using in-vitro...
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Posted by admin on Sep 30, 2021 in |
Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally active anti-mitotic agent that binds tubulin, destabilizes microtubulin polymerization, and arrests tumor cell growth at the G2/M phase. Its tubulin binding site is distinct from that of other microtubulin inhibitors such as taxanes, colchicines, and vinca alkaloids. Many researchers were motivated by this achievement of vinblastine and vincristine (vinca alkaloids) and developed the indole-based new anticancer chemical entities. Indole containing anticancer molecules has shown their anticancer properties through the diverse mechanism of action. The majority of the synthetic indoles have a structural analogy to natural anticancer products (vinca alkaloids or combretastatin) and exhibited anticancer activity through tubulin interactions. The indole ring system is an essential part of many tubulin inhibitors identified in recent years. The Substituted 2-Phenyl-1H-Indol-3yl Glyoxylamidewere was computationally designed and energy minimized. All the designed compounds show zero violations of the rule of 5, which indicates drug-likeness properties and good bioavailability. Among these, several aryl/ heteroaryl substituted indolylglyoxyamides have shown good inhibition towards tubulin...
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Posted by admin on Sep 30, 2021 in |
The goal of the research is to analyze the antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis Decidua (HECD). Themost common neurodegenerative condition which stand second is Parkinson. It is reported by dopaminergic neuron loss in the striatum’s substantia nigra & dopamine loss (DA). Capparis Decidua plant is used as anti-inflammatory, laxative, anti-diabetic, anthelmintic, antibacterial, astringent, digestive and for so many other traditional use, we used this research to scientifically verify Parkinson behaviour using suitable animal models. In mice, using haloperidol (1 mg/kg i.p) catalepsy was induced. Bromocriptine (2.5 mg/kg) and HECD were administered orally to the treatment group at the dose of 100 mg/kg, 200 mg/kg, and 300 mg/kg. Bar tests for catalepsy, motor coordination tests by rotarod, and locomotor activity by actophotometer were performed to evaluate behavioural changes. Dopamine and catalase assay were also carried out to assess biochemical parameters. Using standard as ascorbic acid in UV visible spectrophotometer, evaluation of antioxidant activity by DPPH radical scavenging method were performed. The outcome of our work...
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Posted by admin on Sep 30, 2021 in |
The recommended doses of antacids by some manufacturers are in ranges. However, dosing decisions on antacids should be based on acid-neutralizing capacities (ANCs). This study evaluated the ANCs of different doses of antacids. Twenty-two antacids (3 granular, 5 tablet and 14 suspension formulations) were evaluated for their ANCs at half, minimum, and double their recommended adult doses. All the products complied with the minimum ANC recommendation (5 mEq/dose), although ANCs were significantly different from each other (p < 0.0001). The ANC range for minimum recommended doses for all products was 12.417−38.817 mEq. There were no significant differences in ANCs (p = 0.1662) based on dosage form. A dose-dependent effect was observed when minimum recommended doses were halved or doubled, with significant differences in ANCs at each dose level (p < 0.0001). The ANC range for doubled doses was 19.817-71.133 mEq. The ANCs at half-doses (7.583−20.417 mEq) were also compliant with the regulatory requirement. The findings show that doses smaller than recommended amounts could be indicated for mild hyperacidity conditions,...
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