Posted by admin on Nov 30, 2024 in |
Wound healing remains a significant challenge in modern medicine, necessitating the exploration of innovative therapeutic strategies. Centella asiatica, a widely recognized medicinal herb, has garnered attention for its potential wound healing properties. This study aimed to investigate the efficacy of a Centella asiatica transdermal patch in promoting wound healing. These results suggest that the Centella asiatica transdermal patch holds promise as a novel therapeutic intervention for promoting wound healing. Further research is warranted to elucidate the underlying mechanisms of action and optimize the formulation of the patch for clinical application. This study contributes to the growing body of evidence supporting the use of herbal remedies in wound management and underscores the potential of Centella asiatica as a valuable adjunctive therapy in wound healing. This study investigates the wound healing activity of a transdermal patch containing a combination of Centella asiatica and Liquorice extracts. The patch was formulated and evaluated for its efficacy in promoting wound healing using in-vitro and in-vivo assays. Overall, this study suggests that the Centella asiatica...
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Posted by admin on Nov 30, 2024 in |
Introduction: Malaria is a seasonal disease and endemic in Chhattisgarh, as a large number of cases and deaths are reported from the tribal-dominated districts of Chhattisgarh. The distribution of these malaria parasites can vary across different regions of India due to climate, geography, mosquito vector species present, human population dynamics, and socio-economic conditions. Aims and Objectives: This study was carried out to analyse the trends in the prevalence of malaria parasites from 2018 to 2022in a tertiary care center. Materials and Methods: Retrospective Data from five annual cross-sectional Rapid diagnostic tests for malaria antigen were analysed from a combined sample of 27,844 individuals suspected of malaria. Data collected included demographic profile and test results of malaria parasites by Rapid diagnostic test. Results: The overall malaria prevalence rate detected during the study period was 1.39%. P. falciparum species showed predominance, with a pinnacle of 96.1% (100) in 2020. Malaria cases were found to be more associated with young adults (31.95%) males (62.88%) with peak positivity rate recorded in month of...
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Posted by admin on Nov 30, 2024 in |
Diabetes mellitus can lead to impaired healing of wounds and can cause life-long complications. Curcumin is reported as one of the promising therapeutic agents in the management of impaired wound healing in diabetics. This study aimed to formulate a wound-healing ointment from the extracted curcumin and evaluate its efficacy among diabetes-induced rats. The extract was subjected to organoleptic evaluation, phytochemical screening, pre-formulation studies, and thin layer chromatography. Three trial formulations of ointment were prepared with varying concentrations of the extract. Prior to wound excision, alloxan monohydrate (110 mg/kg) was administered intraperitoneally among thirty male Sprague Dawley rats to induce diabetes. The trial formulations of ointment were then applied in all treatment and control diabetic rat (FBG of > 200 mg/dL) groups for 14 days. The wound-healing activity was assessed through the following parameters: percent wound closure (PWC), period of epithelialization (PE), percentage of scar formed (PSF), and histopathological analysis. Among the trial formulations, 10% extracted curcumin ointment exhibited the highest PWC, fastest rate of wound closure, shortest PE, and...
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Posted by admin on Nov 30, 2024 in |
Luliconazole is an antifungal medication effective against various fungi, especially filamentous fungi like dermatophytes. This study aimed to develop a topical drug delivery system for luliconazole to reduce the active drug dose, improve patient compliance, minimize side effects, and enhance local absorption and activity. Solid lipid nanoparticles (SLNs) were formulated using stearic acid and poloxamer 188 via the solvent diffusion method to address luliconazole bioavailability barriers. The developed SLN and gel formulations underwent physicochemical testing, in-vitro drug release profiles, and kinetics studies. Successful formulation was confirmed by FTIR spectroscopy and scanning electron microscopy. SLN formulation F1 showed significant entrapment efficacy of 96.87 ± 0.009. The SLNs exhibited unimodal size distribution with a polydispersity index of 0.168, intercept value of 0.98 with 92% peak intensity, and zeta potential of 18.8 mV. The mean particle diameter was 344.3 nm. The G3 gel formulation, containing 1.5% w/v carbopol 934, demonstrated superior entrapment efficacy of 91.39±0.187. It also exhibited a sustained release profile, with 79.57±0.213% of the medication released after 24 hours. These...
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Posted by admin on Nov 30, 2024 in |
The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick embryos in response to the rolapitant’s effect. Three hundred fertilised white leghorn chicken eggs were utilised, separated into five control groups (C1 to C5) and five experimental groups (E1 to E5), each with thirty eggs. On the fifth day of incubation, eggs from five experimental groups were exposed to different concentrations of rolapitant at 0.00039 mg, 0.0005 mg, 0.00075 mg, 0.001 mg, and 0.00125 mg respectively, whilst five control groups received the same concentration of normal saline. Chick brains were obtained and weighed. The cerebral cortex (brain) was sectioned and stained to examine the histopathological abnormalities. A significant growth retardation and decreased weight of the...
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