Posted by admin on Apr 30, 2025 in |
Objective: Sunitinib malate is an oral, potent multi-targeted TKI that displays antitumor and anti-angiogenic actions. The core focus of the present research work is to establish an innovative QbD-based analytical method for the estimation of Sunitinib malate in solid dosage form by ultra-high performance liquid chromatography (UHPLC). Materials and Methods: The change in independent variables, wavelength, flow rate and Acetonitrile concentration with response to retention time, area and tailing factor were studied using Box-Behnken design. Chromatographic separation was accomplished by using XBridge shield RP18 (50mm x 3mm, 2.5μm) column, flow rate was adjusted to 0.7mL/min. at a temperature of 25ºC. The detection was carried out at 388nm with a run time of 5 min. Results and Discussion: The retention time of Sunitinib malate was found to be 2.391 min. The method is robust, accurate and precise, as depicted by the statistical data of analysis. The correlation coefficient was found to be 0.999. The solution was found to be stable for 24 hours at 250C. Hence the current research work...
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Posted by admin on Apr 30, 2025 in |
Background & Objective: India is home to two infectious diseases caused by Salmonella: typhoid and paratyphoid fever. The medication of choice for S. typhi is ceftriaxone, a third-generation cephalosporin. Study was carried out on the Surveillance of Enteric Fever in India to ascertain the prevalence, clinical manifestation, and trajectory of antimicrobial resistance (AMR). This work aimed to examine the antibiogram profiles of Salmonella typhi found in patient blood cultures. Second, to record how often Salmonella typhi infections occur located in Vadodara, the Antibiotic Susceptibility Test is third. Material and Methods: The Retrospective study was carried out over a period of 12 months after obtaining ethical approval. The freshly drawn venous blood was placed in a blood culture vial. Following identification of pathogen isolates, Kirby-Bauer disc diffusion test was employed to determine antibiotic drug susceptibility as per CLSI rules. Results: Total 10,126 blood samples were collected. In 84 samples (0.83%), 83 instances of Salmonella typhi and 1 instance of Para typhi B. The ratio of males to females was 1:2....
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Posted by admin on Apr 30, 2025 in |
This study evaluates the pharmaceutical quality of metformin tablets, both generic and branded, available in India. Metformin, a primary medication for managing type 2 diabetes was chosen due to its widespread use and critical role in diabetes treatment. Using in-vitro methods compliant with Indian Pharmacopoeia standards, several quality control parameters were assessed, including hardness, friability, disintegration time, dissolution profile, and weight variation. The research addresses a common misconception that branded drugs outperform generics in therapeutic efficacy. It aims to demonstrate that generic drugs, when meeting established pharmacopeial standards, are bioequivalent to their branded counterparts. Tablets were sourced from the market and government supply, and rigorous testing was performed to ensure the consistency of active ingredients and adherence to pharmaceutical standards. Results showed that all tested samples met the required quality benchmarks. Generic tablets exhibited comparable performance in disintegration time, dissolution rate, and other physical and chemical parameters. These findings highlight the safety, efficacy, and interchangeability of generic metformin tablets with branded alternatives. This study underscores the importance of stringent...
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Posted by admin on Apr 30, 2025 in |
The research study aims to prepare and characterize bilayer tablets that combine Glibenclamide, a sulphonyl urea and Pioglitazone HCl, a thiazolidinedione for enhancing glycaemic control in Type 2 Diabetes. The bilayer design incorporates an immediate-release layer of Glibenclamide for rapid onset of action and a sustained-release layer of Pioglitazone HCl to maintain prolonged therapeutic levels. Using wet granulation process, a 400 mg bilayer tablet was prepared. Eight formulations of the immediate and sustained release layers were prepared using different quantities of Crospovidone and sodium starch glycolate, as well as different viscosity grades of HPMC K4 M and HPMC K100M polymers. The FTIR spectra confirmed that the medication and polymers do not interact chemically. DSC analysis was conducted for an optimized formulation, and no incompatibility was discovered. According to dissolution rate studies of bilayer tablets it was observed that the bilayer tablet showed 94.6% while the marketed tablet showed 82.5% release over a 12-hour period. The optimized formulation of drug release data demonstrated the best fit into zero-order kinetics and...
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Posted by admin on Apr 30, 2025 in |
Pharmaceutical sciences face challenges related to antibiotics toxicity and microorganism resistance. Olax dissitiflora (mussiro) is traditionally used in Mozambique for skin diseases treatment and beauty. The research aims to bring scientific studies for its antimicrobial and antioxidant properties. The hydroethanolic extracts of leaves, stem and stem bark of Olax dissitiflora species were evaluated for their phytochemical composition, antioxidant and antibacterial properties. Thus, total phenols, total flavonoids, hydrolysable and condensed tannins, total alkaloids and antioxidant activity were determined by spectrophotometric method and the correlation between the concentration and activity was made. The antibiotic properties were evaluated by disk diffusion method. The results showed higher phenolic content (159.9 ± 0.9 mg GAE / DE), and higher antioxidant activity for the stem extract in all tested methods: DPPH assay (EC50 = 150.80 ± 0.47 µg/mL), ABTS test (EC50 =25.01 ± 0.05 µg/mL), ferricyanide test (EC50 =23.98 ± 0.14 µg/mL) and phosphomolybdenum test (EC50 = 180.19 ± 0.07 µg/mL) with a very good correlation with the extract concentration. Regarding the antibacterial activity of...
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