Posted by admin on Aug 9, 2021 in |
Pouzolzia zeylanica (L.) Benn. is a medicinal plant widely found in the Asian continent, including the North Eastern (NE) region of India. The plant is being used for its various medicinal properties against wide range of disease conditions as folk medicine in Assam and various places. A research was designed to carry out an evaluation of anti-arthritic activity of the leaves of Pouzolzia zeylanica (L.) Benn. with special reference to its protective effect against arthritis-induced different pathological manifestations. Anti-arthritic activity of methanol extract of Pouzolzia Zeylanica (L.) Benn. leaf was investigated in two dose levels and further various studies were carried out to ascertain the degree of reversing the arthritic manifestations induced by formalin. LD50 values of the extract were found to be safe up to 2000 mg. The in vivo biological studies on male Wister rats at the doses of 250 mg and 500 mg/kg body weight respectively was carried out taking Aceclofenac as standard. The methanol extract of Pouzolzia zeylanica (L.) Benn. leaf, significantly improved the arthritic...
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Posted by admin on Jul 31, 2021 in |
The objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FEG2, and FEG3 manufactured by Carbopol 934 and FEG4, FEG5, and FEG6 by Xanthan gum, and the formulations FEG7, FEG8, and FEG9 were prepared by HPMCK15M as a dispersion phase. The formulation was an evaluation for physicochemical properties of drug and polymers, rheological studies, In-vitro drug release studies, Zero-order, and first-order release kinetics studies. The in-vitro release of the microemulsion drug was greater than the commercialized formulation. The Hind paw method (Acute inflammatory model) test was performed in rate to evaluate the analgesic activity of fabricated emulgel. The overall findings of this study suggest that the developed emulgel formulation of diclofenac sodium can be used potential approach for the management of analgesic...
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Posted by admin on Jul 31, 2021 in |
The present study aimed at comparing the antioxidant potential of three different samples of Eclipta alba-fresh plant, marketed leaf powder (packaged in sealed containers), and marketed whole plant (sold in open bags). The presence of alkaloids, saponins, triterpenes, terpenoids, tannins, steroids, flavonoids, glycosides was confirmed in all three samples. Fresh plant samples showed a higher antioxidant activity determined using standard ferric reducing antioxidant power (FRAP) assay (3105.16 ± 202.07 AAE/gm. dry weight) and 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay (32.37 ± 5.94%). Fresh plant samples also had a higher content of secondary metabolites such as total phenolics and alkaloids as compared to the other two samples. A high correlation was observed between antioxidant capacity and total phenolic content (R2 = 0.997). Loss of antioxidant potential in marketed samples indicates that proper processing and storage are important in ensuring the viability of the raw material of medicinal...
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Posted by admin on Jul 31, 2021 in |
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of dosage by converting the drug into nanoparticles and superdisintegrant technology; the drug undergoes solubility and gastrointestinal permeability. By adopting these technologies, it achieves by enhancing the disintegration time of drug when comes in contact with water. Here I would like to promote the range of method development technologies improving the solubility and permeability of class IV drugs in...
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Posted by admin on Jul 31, 2021 in |
Self-medication with OTC drugs is observed in many countries and deserves due concern as it may adversely affect maternal and fetal health. This practice may have an association with socio-demographic factors and knowledge about OTC medicine. A descriptive study was done using a questionnaire that collects information on socio-demographic status, prevalence and knowledge of OTC medicine use among pregnant women. The pregnant women visiting government hospitals in the A sir region were randomly selected. The data collected was analyzed by SPSS software version 20. Moderate level of knowledge about OTC medicine was observed in more than half the sample. More than two-third of the sample was found to have used OTC medicine during their pregnancy. High prevalence of OTC medicine use was found among the unemployed and university-educated sample groups. There was significant association between age of the mother and OTC medicine use, while the association with other socio-demographic variables was not significant. The highest prevalence of OTC medicine use was observed in the sample with a high level...
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