Posted by admin on Oct 31, 2024 in |
The development of a dependable green chemistry approach for the biogenic production of nanomaterials is an essential component of contemporary nanotechnology research. The biosynthesis of metal nanoparticles is a widely acknowledged method that employs a bottom-up approach with reduction as the primary process. When compared to chemical approaches, the nanoparticles created by this method are safer, more cost-effective and less harmful to the environment. Metallic nanoparticles with bactericidal and inhibitory properties include silver nanoparticles. Pathogenic bacteria have become more resistant to antimicrobial medicines in recent years, which presents a significant challenge to the healthcare system. Additionally, the fast development of antibiotic resistance during this time has made scientists and researchers reconsider the therapeutic potential of silver and its nanoparticulate systems as possible antibacterial and antifungal agents. In the present investigation, we have comparatively studied the antimicrobial and antifungal activity of 1mM, 0.1 M solution of silver nitrate, silver nanoparticles synthesized from aqueous and ethanolic leaf extract and Cd- doped silver nanoparticles and antioxidant activity of aqueous and ethanolic extract...
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Posted by admin on Oct 31, 2024 in |
Aim: Patients often experience varying degrees of pain during or after root canal therapy. This study aimed to the analgesic effect of the combination of intra-canal analgesics and Cryotherapy in controlling pain during non-surgical root canal treatment. Methodology: This Double-blind, parallel, randomized clinical trial included 76 patients (42 men and 34 women) within the age range of 18-65 years with maxillary or mandibular premolars having symptomatic irreversible pulpitis or symptomatic apical periodontitis. Patients were divided into two groups: Group 1 received precooled analgesic solution for irrigation during root canal treatment, Group 2 used Ketorol DT tablets during and post root canal treatment. Pain levels were assessed using the visual analogue scale (VAS) before treatment, during treatment, and at 2, 6, 12, 24 hours inter and post-treatment. Statistical analysis included mean, standard deviation, Mann Whitney U test and Wilcoxon Signed Rank Post Hoc tests. Results: There is a significant decrease in the levels of pain in the patients at 6 hours post cleaning and shaping across both the groups. It...
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Posted by admin on Oct 31, 2024 in |
The present investigation focuses on analysis of the active compounds present in the Clerodendrum infortunatum L. leaves extract of different solvents as Petroleum ether and methanol with help of the advance tools like GC-MS and FTIR which posses different pharmacological activities like wound healing, anti-inflammatory, anyalgesic, etc. The leaves were treated with petroleum ether followed by a 50% methanolic extract. The extractability percentage of the petroleum extract was 5.71%, whereas the methanolic extract had a value of 21.88%. The phytochemical study of extracts indicated the presence of alkaloids, glycosides, carbohydrates, phytosterol, phenolic compounds, tannins, and flavonoids. Fourier Transform Infrared Spectroscopy (FT-IR) analysis revealed functional groups of phenols, alcohols, alkane, carboxylic acids, and their esters, as well as primary amines and proteins in both 50% methanolic and petroleum ether extract. GC-MS analysis revealed presence of 51 compounds in petroleum ether and 27 compounds in 50% methanolic...
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Posted by admin on Oct 31, 2024 in |
Introduction: Triphala Churna a polyherbal Ayurvedic formulation – with significant therapeutic potential is used to treat a variety of oral ailments. To ensure product’s quality and effectiveness, it is essential to evaluate its microbiological stability. Materials and Methods: Triphala Churna was prepared using standard procedures and stored in various containers for ten months under different real-world storage conditions, without specific control over temperature or humidity. Microbial contamination was assessed periodically through Gram staining for bacteria, wet mount preparation for fungal visualization, and culture methods for isolating and identifying potential microbes. Discussion: No bacterial or fungal growth was observed in any of the samples throughout the ten-month study period, even under conditions that could potentially support microbial growth. The preparation, storage, and inherent qualities of the individual ingredients in the formulation may have contributed to the observed findings. Conclusion: This preliminary study indicates good microbial stability of Triphala Churna under real-world storage conditions. However, further research using a wider range of microbial detection methods is needed for a more comprehensive...
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Posted by admin on Oct 31, 2024 in |
Background: Understanding the dynamic profiling of emergency department (ED) visits, particularly among pediatric patients, is crucial for implementing targeted interventions to enhance outcomes and optimize triage systems for this vulnerable population. Aim and Objective: This study aimed to profile the demographics, clinical presentations, and treatments of pediatric patients admitted to the ED. Materials and Methods: Conducted as a prospective observational study over six months in South India, this research included 110 participants. Sociodemographic and clinical data were collected and analyzed using IBM SPSS software version 29.0. Results: The male-to-female ratio among participants was 1.2:1, with children aged 1 to 10 constituting 48.1% of the cohort. Febrile seizures emerged as the most common diagnosis, accounting for 17.3% of cases. Acetaminophen was the most frequently prescribed medication, used by 30.0% on admission and 12.7% upon discharge. Drug-drug interactions (DDI) were significant, with 92.7% classified as moderate and 7.3% as severe. The mean length of hospital stay was approximately four days, and polypharmacy was noted in 52.8% of patients. Conclusion: The predominance...
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