Posted by admin on Apr 30, 2025 in |
This descriptive observational study was conducted at Government Medical College and Dr. Susheela Tiwari Memorial Government Hospital, Haldwani, Uttarakhand, to evaluate the seroprevalence and clinico-epidemiological profile of chronic Hepatitis B (HBV) and Hepatitis C (HCV) among patients. Over a two-year period, 7,149 outpatients were screened, identifying 38 HBV-positive cases (0.53%) and 141 HCV-positive cases (1.97%). Patients were assessed using detailed clinical evaluations, laboratory tests, and imaging studies, with data analyzed through SPSS. The majority of patients with HCV presented with advanced liver disease, as evidenced by higher rates of ascites (13.97%), jaundice (11.73%), and elevated urea levels (p=0.03), while HBV patients exhibited significantly higher serum bilirubin (p=0.005) and SGOT levels (p=0.0057). Sociodemographic analysis revealed no significant differences in age, gender, or education between groups, but geographic patterns showed HBV predominance in Nainital (63.2%) and HCV dominance in Udham Singh Nagar (27.7%) and Bijnor (29.1%). These findings underscore the urgent need for targeted interventions, including awareness campaigns, preventive measures, and region-specific healthcare strategies, to reduce the burden of viral hepatitis...
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Posted by admin on Apr 30, 2025 in |
The renal system helps in the urinary excretion of drugs in unchanged form or metabolites. Since a majority of the drugs are eliminated by the kidneys, impairment in renal function can lead to drug accumulation, toxicity, and therapeutic failure. As a result, patients with impaired renal function require careful dose modifications. The purpose of this study was to determine the most frequently prescribed dose-unadjusted antibiotic and to assess the appropriateness and rationality of antibiotic dose adjustments in patients with Chronic Kidney Disease (CKD). Additionally, the study aimed to pinpoint the factors contributing to incorrect dosing adjustments. A retrospective observational study was conducted from December 2022 to November 2023 and medical records of the study subjects admitted to the nephrology department of Mallige Medical Centre, Bengaluru, were reviewed for antibiotic prescriptions. This study included 651 participants in total, with a p < 0.05 level for statistical significance. The findings showed that 35 different antibiotics were prescribed to patients with CKD, with 71.42% (25/35) requiring renal dose adjustments. Notably, 51% (332/651)...
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Posted by admin on Apr 30, 2025 in |
The synthesis of metal oxide nanoparticles has emerged as a burgeoning field of research due to its promising applications in advancing technological frontiers. Particularly, the utilization of biologically derived nanomaterials has gained significant traction within the realm of nanotechnology. Tamarindus indica plant extract has demonstrated efficacy as a viable precursor for the synthesis of silver nanoparticles. Tamarindus indica, being a locally abundant plant, boasts a rich composition of essential amino acids and vitamins. This investigation presents the biosynthesis of metal oxide nanoparticles using an aqueous extract derived from Tamarindus indica. The aqueous extract and resultant nanoparticles underwent comprehensive characterization techniques such as XRD, DLS, UV, SEM, and EDS. Additionally, this study delves into the antimicrobial properties of the synthesized compound. By minimum inhibitory concentration (MIC) and Agar diffusion method of the extract against various test organisms was conducted, with results indicating antimicrobial activity against both gram-positive and gram-negative bacteria as well as fungi. The efficacy of the antimicrobial effect was assessed by measuring the diameter of the inhibition zone....
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Posted by admin on Apr 30, 2025 in |
Background: Patients with respiratory diseases are frequently treated with inhaled corticosteroids (ICS) to lower the likelihood of exacerbations. Research to date indicates that ICS treatment has a significant impact on eosinophils counts, which is a phenomenon with wider consequences. Therefore, to maximize the benefits of ICS therapy, it is necessary to investigate the intricate interplay between ICS and eosinophils. Aim and Objective: Our research aimed to assess the influence of inhaled corticosteroids (ICS) on eosinophils counts, as well as the safety and adherence of ICS therapy. Materials and Methods: The single-centered prospective observational study was conducted over three months with 69 patients. The sociodemographic and clinical information were recorded. The ICS’s safety and adverse effects were evaluated using the Inhaled Corticosteroid Questionnaire (ICQ). The Morisky Medication-Taking Adherence Scale-MMAS (4-item) was used to evaluate the medication-taking behavior. Statistical significance was defined as a P < 0.05. Results: Of 69 patients, 42 were in the study arm (with ICS) and 27 in the control arm (without ICS). The mean age of the study arm was 55.2 years,...
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Posted by admin on Mar 31, 2025 in |
Levocetirizine Dihydrochloride is an orally active, non-sedative antihistamine drug. To determine the assay content of Levocetirizine Dihydrochloride drug substance, a very simple, accurate, specific, and precise UV-Spectrophotometric method has been built up as well as evaluated. The suggested method comprises dissolving Levocetirizine Dihydrochloride in distilled water and subjecting the consequential solution to UV Spectroscopic measurement. An absorption maximum was found to lie at about 230 nm and the measurements were carried out at this wavelength. Beer’s law was followed in the concentration range of 4 to 32 μg/ml. The linearity showed on the calibration curve between concentration and absorbance by the line equation of y = 0.0304x + 0.0002 (R² = 0.9997). Reproducibility by repeating methods as %RSD was found to be less than 2%. The results of the accuracy and precision were found very satisfactory and here the suggested method was statistically validated as per the ICH guidelines in terms of specificity, linearity, accuracy, precision and robustness. Validation studies have discovered that the method is simple, specific, rapid,...
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