Posted by admin on Jun 30, 2021 in |
Genus Curcuma L. ( Zingiberaceae), comprising of 120 species, is distributed throughout South and South-East Asia, with few species extending to China, Australia, and South Pacific. Four species of Curcuma are reported from Melghat. Of these C. longa L. is cultivated while C. inodora Blatt., C. pseudomontana J. Graham and C. decipiens are wild. C. decipiens being rare could not be collected. Curcuma inodora Blatt. Known as ‘Jangali Halad’ is a common herb of Melghat at higher elevations. In the Melghat area, populations of C. inodora are found to show many distinct variations in aerial as well as underground characters. Twelve distinct variants of C. inodora and C. pseudomontana and C. longa were collected. HPTLC screening of free amino acids showed the presence of four to eleven amino acids in Curcuma inodora accessions, while in C. pseudomontana and C. longa, ten amino acids each were found. Glycine and Proline were found in all samples studied. Amino acid composition is specific for each species and variants; hence can be used...
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Posted by admin on Jun 30, 2021 in |
Inflammation is a chemical-mediated defense mechanism of body. Inflammatory process is also associated with development of various diseases like rheumatoid arthritis, psoriasis, atherosclerosis, and diabetes. Diabetes mellitus is a most common and life-threatening health problem in today’s date. Several marketed anti-diabetic drugs are characterized with side effects. Hence there is a need to search a safe and effective anti-diabetic drug. In that regard, the present study was carried out to ascertain phytochemical constituents and to evaluate the anti-inflammatory and anti-diabetic effect of an Indian traditional medicinal plant, Holarrhena pubescens (seed). The dried and powdered seeds of H. pubescens was extracted by ethanol and then fractionated successively. These fractions were evaluated further for anti-inflammatory activity by in vivo models for acute and chronic inflammation. The anti-diabetic activity of plant materials was evaluated by oral glucose tolerance test and blood sugar estimation in streptozotocin-induced diabetic rat model. The results of the present study illustrated that the petroleum ether fraction (HPPT) of the plant material at 400 mg/kg dose showed the most...
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Posted by admin on Jun 30, 2021 in |
A stability-indicating method by UV spectrophotometry has been developed for the specific determination of Amorolfine HCl in bulk in the presence of its degraded products. The method is simple, accurate, precise, and robust. Experiments were designed for determining linearity, the limit of detection and quantitation, accuracy, precision, and specificity of this analytical method as per the International Organization for Standardization guidelines. The drug substance was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analyzed using the proposed method to demonstrate the specificity of the method. The proposed method was found to be linear in the concentration ranges from 2-20µg/ml with the linear correlation coefficient of R2= 0.990, and the mean recovery was 95.59 % at a detection wavelength of 215 nm. Although the degradation products of stressed conditions had not been identified, the method had been able to detect the changes due to stress conditions. The stated method can be used as a stability-indicating method with a high degree of linearity, accuracy, and...
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Posted by admin on Jun 30, 2021 in |
Urolithiasis is a common urological disorder responsible for serious human affliction and cost to society with a high recurrence rate. The aim of the present study was to systematically evaluate the leaf extract of Citrus medica using suitable in-vitro and in-vivo models to provide scientific evidence for its antilithiatic activity. Cystone has been suggested to be beneficial in urolithiasis, as it corrects the crystalloid, colloid stability. It is evaluated that flavonoids, triterpenoids and saponins from different plants resulted in the antilithiatic activity. To explore the effect of Citrus medica on sodium oxalate crystallization, in-vitro assays like crystal nucleation and aggregation were performed. The biochemical parameters like calcium, oxalate, magnesium, phosphate, sodium, and potassium were evaluated in urine, serum, and kidney homogenates. Histopathological studies were also done to confirm the biochemical findings. In-vitro experiments with Citrus medica showed concentration-dependent inhibition of sodium oxalate nucleation and aggregation. In the in-vivo model, Citrus medica reduced both sodium and oxalate supersaturation in urine, serum, and deposition in the kidney. The biochemical results were...
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Posted by admin on Jun 30, 2021 in |
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer’s. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered with AlCl3 at a dose of 4.2 mg/kg/day i.p. for 4 weeks. Experimental rats were given Buchnania Lanzan Leaf extract in two different doses of 200 mg and 400 mg/kg/day orally 1hr before the AlCl3 administration for 4 weeks. Learning and memory parameters were evaluated using elevated plus maze (EPM), Radial Arm Maze, and T Maze paradigms. Results: The preliminary phytochemical investigation of Buchnania Lanzan Extract showed the presence of carbohydrates, alkaloids, flavonoids, phenols, tannins, saponins. In this study, Buchnania lanzan leaves extract was an administration for 28 days showed significant neuroprotective activity in aluminum chloride-induced rats of cognitive impairment and oxidative stress analyzed by using various behavioral Studies. Conclusion:...
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