Posted by admin on Mar 31, 2025 in |
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality, ranking third after throm-boembolism and hypertensive disorders. The primary goal of this study was to determine the effectiveness of balloon tamponade in the prevention and treatment of postpartum hemorrhage. The principle of balloon tamponade is to apply direct pressure to the bleeding vessels of the placental area using the wall of an inflated balloon within the uterus. The basic study included both retrospective and prospective research. The retrospective study group (no balloon tamponade performed) consisted of 72 patients, of whom 34 delivered vaginally and 38 underwent cesarean section. The prospective study group (balloon tamponade performed) included 40 women (20 with vaginal deliveries and 20 with operative deliveries). The effectiveness of the treatment was assessed based on two criteria: the volume of blood loss and the number of hysterectomies performed. In our study, the effectiveness of balloon tamponade was found to be 95%, based on the complete cessation of bleeding and the reduction in the length...
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Posted by admin on Mar 31, 2025 in |
Introduction: Adverse events following immunisation (AEFI) are frequently underreported in India for numerous reasons, ultimately impacting the country’s immunisation program. The current study evaluates the knowledge, attitudes, and reporting practices (KAP) on vaccine vigilance among physicians in our hospital. Objectives: To find out various causes of Under-reporting of adverse events subsequent immunisation. Materials & Methods: Using a standard questionnaire, 200 doctors were interviewed. Responses were documented and analysed. Doctors had 37.8% knowledge while 68.9% had a good attitude but had poor reporting practices 34.6%. Results: Lack of knowledge, difficulty in filling reporting form, time constraints were the common causes for the under-reporting. Conclusion: Enhancing the perspective of AEFI, adequate training, and proactive involvement in reporting by healthcare practitioners could strengthen the nation’s vaccine surveillance...
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Posted by admin on Mar 31, 2025 in |
Candesartan Cilexetil (CC) traditional dosage form has poor bioavailability and quick first pass metabolism, which leads to rapid elimination of the drug from the system and reduced plasma drug concentration during early morning heart attack incidence. The primary purpose of the Candesartan Cilexetil chronotherapeutic formulation is to optimally release the medicine in greater amounts in the early morning hours (when it is most needed) and in lower amounts at night (when it is least needed). Because systolic and diastolic blood pressures increase fast in the early morning by at least 15 to 25 mmHg and peak late in the day, Candesartan Cilexetil was successfully developed as microsponges to enhance its solubility and bioavailability and delivered as the pulsatile release (Pulsincap dosage form) for delivering the drug after the lag time of 5-6 h for the chronomodulated release of the drug. Microsponges and Pulsincap were subjected to various formulation parameters like FTIR, DSC, encapsulation efficiency, SEM, in-vitro dissolution and kinetic study. F9 formulation was selected as best formulation as it...
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Posted by admin on Mar 31, 2025 in |
Propranolol hydrochloride, a non-selective beta-blocker, has emerged as a first-line treatment for infantile hemangioma due to its vasoconstrictive, anti-antigenic, and pro-apoptotic effects on endothelial cells. This research focuses on the development of topical gel, for the localized treatment of infantile hemangioma, aiming to reduce systemic side effects while enhancing therapeutic efficacy. The formulations were prepared using suitable gelling agents and emulsifying components. Several physicochemical tests were conducted, including spreading ability, viscosity, moisture content, and moisture uptake, to evaluate the formulations’ properties. The emulgel demonstrated superior results in terms of spread ability and a balanced viscosity that facilitated both ease of application and prolonged contact with the skin. Moisture content and moisture uptake studies suggested that the emulgel maintained skin hydration better than the aqueous gel. In conclusion, the emulgel exhibited enhanced physicochemical characteristics, making it a more promising option for the topical treatment of infantile hemangioma compared to the aqueous gel. Further clinical evaluations may solidify its potential as an effective and safe therapeutic...
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Posted by admin on Mar 31, 2025 in |
A series of novel (2,4-bis(arylamino) thiazol-5-yl) (thiophen-2-yl) methanone derivatives were synthesized and analyzed using various analytical and spectral techniques, including elemental analysis, IR spectroscopy, ¹H NMR, ¹³C NMR, and mass spectrometry to ensure comprehensive structural validation and accurate determination of their chemical composition and framework. Structural optimization and theoretical vibrational spectral interpretations were performed using density functional theory (DFT) calculations. The study examined critical molecular properties, such as charge transfer phenomena, chemical stability, HOMO-LUMO energy gaps, Natural Bond Orbital (NBO) analysis, Molecular Electrostatic Potential (MEP) mapping, and Non-linear Optical (NLO) properties. Biological testing indicated that all synthesized compounds exhibited significant antibacterial activity. Among these, (4-((4-chlorophenyl) amino)-2-(4-ethoxyphenyl) amino) thiazol-5-yl) (thiophen-2-yl) methanone emerged as the most potent antibacterial agent. Molecular docking studies were conducted with the 3IP4 and 1KEB receptor proteins, shedding light on the potential binding interactions and underlying mechanisms. This comprehensive study showcases the synthesis, theoretical evaluation, and biological potential of these thiazole-based derivatives, highlighting their promise as candidates for developing effective antibacterial...
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