Posted by admin on Aug 31, 2025 in |
Background: The present investigation was aimed at developing, optimize and evaluate gastroretentive floating tablets containing Losartan potassium to retain in the stomach for prolong and predictable period of time for hypertensive patients. In the present study, the effect of HPMC K15M showed prolong release of drug in gastric pH environment. Results: These formulations were evaluated for the parameters like drug excipient compatibility study, thickness, hardness, tablet density, floating lag time, total floating time, weight variation test, % friability, drug content, % swelling index and accelerated stability studies. On the basis of preliminary results, the amount of HPMC K15M (X1) and the amount of MCC (X2) were chosen as independent variables in 32 full factorial design while % Friability (%F) and Cumulative % drug release at 12 hrs (Q12) were taken as dependent variables. Multiple linear regression analysis, ANOVA and graphical representation of the influence of factors by contour plots were performed using Design Expert. In-vitro release data were fitted to various models to ascertain kinetic of drug release. The...
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Posted by admin on Aug 31, 2025 in |
Breastfeeding mothers often experience milk leakage and discomfort, highlighting the need for innovative, sustainable and hygienic nursing pads. This study explores the potential of banana pseudostem fibre as a natural, eco-friendly material for nursing pads. The research involves the extraction, processing and characterization of banana pseudostem fibres, followed by the development of a novel nursing pad prototype. The water absorption and antibacterial properties of the banana pseudostem fibre were evaluated, showing a high-water absorption percentage (88.52%) and broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. The results demonstrate the suitability of banana pseudostem fibre as a sustainable and hygienic material for nursing pads. The developed prototype offers improved comfort, support, and absorbency, minimizing the risk of bacterial growth and infection. This research contributes to the development of eco-friendly, sustainable, and hygienic nursing pads, addressing the needs of breastfeeding mothers while promoting environmental...
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Posted by admin on Aug 31, 2025 in |
Millets are small-seeded grasses that have nutraceutical properties due to high content of proteins, dietary fibre, vitamins, antioxidants, and other valuable phytochemicals, important for health and wellbeing. The objective of the research was to analyse the phytochemical compounds and antioxidant properties of minor millet varieties viz., Kodo, Proso, Barnyard, Finger, Foxtail, and Little Millets. A quantitative phytochemical examination revealed the presence of phenols, steroids, alkaloids, saponins, flavonoids, and tannins irrespective of the extraction method used. Antioxidant assay was done by the phosphomolybdate method. These findings indicate that different millet types possess distinct phytochemical profiles. Finger Millets and Foxtail Millets were rich in phenols and flavonoids, while Barnyard Millets had increased levels of alkaloids, saponins, and tannins. The antioxidant evaluation of Kodo, Proso, Barnyard, Finger, Foxtail, and Little Millets extracts showed that the Finger millet exhibited the highest antioxidant activity (4.12 μg AAE/ml in DW and 5.34 μg AAE/ml in Me). Methanol extracts generally showed higher antioxidant values than distilled water extracts, indicating that methanol is a more effective solvent...
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Posted by admin on Aug 31, 2025 in |
Introduction: Hypertension is a leading global health concern, contributing significantly to cardiovascular morbidity and mortality. Despite the availability of various antihypertensive therapies, the optimal treatment regimen, particularly in diverse populations, remains a subject of ongoing research. This study aims to compare the efficacy, safety, and patient satisfaction of two commonly prescribed antihypertensive combinations: Losartan + Amlodipine and Losartan + Hydrochlorothiazide (HCTZ). Materials & Methods: This prospective, randomized, open-label study involved 300 newly diagnosed hypertension patients (aged 18-80) at UPUMS, Saifai. Patients were randomly assigned to Group A (Losartan + Amlodipine) or Group B (Losartan + Hydrochlorothiazide). Over a year, blood pressure, heart rate, and adverse effects were monitored at baseline, 4 weeks, and 12 weeks. Data were analyzed using SPSS, with significance set at p < 0.05. Ethical approval was obtained. Results: The baseline demographic characteristics showed no significant differences between the two groups. In Group A (Losartan + Amlodipine), 54.67% were male, and 45.33% were female. Group B (Losartan + Hydro-Chlorothiazide) had 50.67% males and 49.33% females. Age...
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Posted by admin on Aug 31, 2025 in |
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder marked by insulin resistance, impaired insulin secretion, and persistent hyperglycaemia. It accounts for over 90% of global diabetes cases and contributes to approximately 9% of global mortality, equating to nearly four million deaths annually. With a rising burden in rural areas, identifying the prevalence and risk factors is crucial for effective public health planning. This study aimed to assess the prevalence of T2DM and its associated risk factors in a rural population aged 30 years and above in Gwalior district, Madhya Pradesh. Methods: A community-based cross-sectional study was conducted from 1st May 2023 to 30th April 2024 in the rural area of Gwalior. A total of 250 individuals aged 30 years and above were enrolled. Data collection included demographic characteristics, lifestyle risk factors, BMI categorization, smoking, and alcohol consumption status. Fasting blood glucose levels were measured to identify diabetes and impaired fasting glucose. Results: The overall prevalence of T2DM was 14.8%, while 20% of participants exhibited impaired fasting...
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