Posted by admin on Mar 31, 2021 in |
Usage of incense smoke has aesthetic importance. But, studies have shown that incense smoke has oxides of carbon, nitrogen, sulphur, which has ill effects on human health. Polyphenol analysis showed the presence of phenol-like compounds in the water extracts of the incense. This study was conducted to understand the impact of exposure of cells to these types of smokes by performing viability test using squamous epithelial cells. Different methods followed to confirm the results, and the results of these studies showed that 80% of the squamous epithelial cells survived when exposed to smoke as compared to controls (no smoke treatment). Further studies were extended on the cell lines BEAS-2B (normal lung cells) and cancerous cells EB-3 cells. Results based on the catalase assay and microscopic studies show that incense smokes have a lethal effect on the normal cells while not showing any harmful effects on cancerous cells and these studies reproduced using trypan blue...
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Posted by admin on Mar 31, 2021 in |
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[6-chloro-2- methyl-4-oxoquinazolin -3(4H)-yl] benzoic acid as intermediate-II. This resulted in intermediate-II undergo mannich base reaction to produce novel quinazolinone derivatives (Q1 – Q16) on the reaction of formaldehyde with different aromatic amines. Sixteen different quinazolinone derivatives were synthesized. Structural assignments of these compounds have been made by elemental analysis, FTIR, 1H NMR, and mass spectral data. Among the synthesized compounds Q3, Q8, and Q 15 showed high anti-inflammatory activity against standard drug Diclofenac sodium. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory...
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Posted by admin on Mar 31, 2021 in |
The objective of the present investigation was to formulate and evaluate ion-activated in-situ gel using the herbal drug catechin, a potential natural antioxidant for the treatment of glaucoma by lowering oxidative stress. A total of eight formulations were prepared and evaluated for parameters, namely physical appearance, gelling capacity, pH measurement, rheological studies, the effect of sterilization, drug content, in-vitro diffusion study, isotonicity evaluation, ocular irritancy studies, and stability test. Pre-formulation studies confirmed that the drug and polymer are compatible with each other. The XSG-2 formulation showed a maximum percentage drug release of 95.45%, which was considered as an optimized formulation and showed 5-6 folds increase in viscosity after gelation, which indicated good residence time further formulations were found to be non-irritating with no ocular toxicity and good stability. The current study results conclude that the developed catech in loaded ophthalmic in situ gel can be considered a better alternative approach to the conventional eye drop with an increase in precorneal residence time, reduced frequency of dosage, and patient compliance...
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Posted by admin on Mar 31, 2021 in |
In the present work, a series of some novel substituted benzimidazole derivatives were efficiently synthesized, and a thin layer chromatography study confirmed the completion of the reaction on silica gel-G plates. The characterization was done through recording spectra of FTIR using Jasco FTIR-460 plus spectrophotometer, recording spectra of 1HNMR with the help of spectrometer, specifically BRUKER 400MHz. The synthesized substituted novel benzimidazole derivatives were screened for their in-vitro antitubercular activity by the Microplate Alamar Blue Assay (MABA) method against Mycobacterium tuberculosis (H37Rv strain) with their 2D-QSAR studies. The antitubercular activity results confirmed that compounds DPK3d1, DPK2d1, DPK2d2, DPK2d3, DPK4B1d2, DPK4B2d1, and DPK4B2d2 had shown potent antitubercular activity as compared to standard drugs. These synthesized derivatives were selected 2D-QSAR analysis with their different models such as multiple linear regression (MLR), and partial least squares regression (PLR) analysis were generated to find out the correlation between physicochemical properties parameters and their biological activity. 2D-QSAR models such as MLR and PLS method studies generated an equation showing that descriptors SsOHcount, Ipc Average,...
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Posted by admin on Mar 31, 2021 in |
The primary purpose of this study was to formulate a mucoadhesive vaginal tablet of clindamycin phosphate. It developed to achieve an excellent therapeutic effect and patient compliance in the treatment of bacterial vaginosis. The formulation has a sustained-release effect with good mucoadhesion due to mucoadhesive polymers like Polycarbophil and Carbopol 971P NF, which decreases dose frequency. The mucoadhesive vaginal tablets were prepared by the direct compression method. FTIR had employed to study drug excipient incompatibility. The analytical method performed using HPLC. Optimization of the formulation was done by 32 full factorial designs using DOE. The mucoadhesive vaginal tablet was evaluated for % swelling index, Muco-adhesive strength, drug content, % drug release, and ex-vivo mucoadhesion time. The ex-vivo mucoadhesion time of optimized batch was up to 9 h, 97.24% drug content, 88.34 ± 0.97% drug release observed at 8 h. Stability study shows developed mucoadhesive intravaginal tablet was stable at 30 °C ± 2 °C at 65 ± 5% RH (Room temperature) and 40 °C ± 2 °C at 75...
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