Posted by admin on May 31, 2021 in |
Brahmi (Bacopa monnieri Linn.) is a miraculous Ayurvedic drug used commercially in memory-enhancing formulations. Its nootropic action is due to Bacoside A, which modern parameters have proved. Bacoside A content fluctuated during the course of the whole year. In the present study, High-Performance Liquid Chromatography was conducted to evaluate total Bacoside A content (expressed as the sum of Bacoside A3, Bacopaside II, Jujubogenin and Bacopasaponin C) on a monthly basis in methanolic extract of Bacopa monnieri collected from the wild and cultivated area during Summer, Rainy and Winter season of a year. Instead of the entire herb, 10 cm apex part and the remaining part of Brahmi were used. Chromatographic analysis was performed with Shimadzu Prominence HPLC instrument; equipped with a quaternary pump, LC2010CHT, degasser DGU-20A3R, Column oven CTO-10As, Autosampler SIL-20 HT, Diode-Array-Detector SPD-M20A with Prime SIL C18 column. Among individual plant parts, maximum Bacoside A content was observed in the remaining part of a plant in July for the wild sample (38.86%) and in the remaining part of...
Read More
Posted by admin on May 31, 2021 in |
Objective: To assess the response of Preterm neonates to Tactile and Kinesthetic Stimulation. Methods: The study was conducted in a Neonatal Intensive Care Unit of a tertiary care hospital in India. Twelve stable preterm neonates were selected as per the inclusion and exclusion criteria and randomized into the intervention and control group. Seven days of tactile and kinesthetic stimulation was given three times in a day to intervention group along with the routine care, and the control group was given only the routine care. The pre and post-test assessment was done among both the groups. The weight gain and other physiobehavioural parameters were compared with the control group. Result: The preterm neonates in the intervention group gained more weight than the control group, and also there was a significant difference found in the physio-behavioural parameters between the two groups. Conclusion: Tactile and kinesthetic stimulation is a non-invasive cost-effective intervention that promotes weight gain and reduces hospital stay. Hence it can be recommended to the preterm neonates in the Neonatal...
Read More
Posted by admin on May 31, 2021 in |
This study aims to identify the suitable method for extraction of polyphenols from Acacia leucophloea bark using enzymes and to optimize the processing condition for extraction using Response Surface Methodology. A microwave-assisted enzymatic extraction (MAEE) method was developed and optimized to augment the polyphenol yield. The optimal extraction conditions were as follows: the amount of cellulase 1%, agitation speed 108 rpm, incubation time 1.5 h, and irradiation time 6 min. Under these conditions, polyphenol yield could reach 6.31%, which was higher than other extraction methods studied. The antioxidant activity of the crude extract and the encapsulated extract was evaluated by DPPH radical and reducing power assay. The antibacterial activities of crude extract and the encapsulated extract were studied using the disc diffusion technique. Among the tested bacteria, Klebsiella pneumoniae was most susceptible to polyphenol extract with the highest inhibition zone of 18.6 ± 0.5 mm at the concentration of 8 mg/mL. The outcome of the study indicates that the MAEE method was efficient and eco-friendly, and the polyphenols have...
Read More
Posted by admin on May 31, 2021 in |
The main objective of the present research work was to formulate and characterize the linagliptin-loaded solid lipid nanoparticles (SLNs). SLNs possess distinctive characteristics like small and spherical shapes with an average diameter between 1to 100 nm. Linagliptin is used for the treatment of type II diabetes and it is a dipeptidyl peptidase 4-inhibitor and its oral bioavailability is 30%. The application of biopharmaceutical principles to the physicochemical properties of drug substance are characterized with the goal of designing best drug delivery system. The current research work was to enhance the oral bioavailability of linagliptin using the different phospholipids like stearic acid, glyceryl monostearate, cholesterol along with the surfactants like tween 80, span 80, poloxamer1 88, and span 20 by solvent emulsification/solvent evaporation method and solvent emulsification method in order to obtain the best novelty formulation. The prepared formulations have been evaluated for particle size analysis, zeta potential, percentage drug entrapment efficiency, scanning electron microscopy studies, in-vitro drug release kinetics, and stability studies. FT-IR spectra showed the there was no...
Read More
Posted by admin on Apr 30, 2021 in |
Background: Management of hypertension in hemodialysis patients was never the same in all and tends to involve a various classes of drugs with respect to their disease conditions, response to drug therapy, medication adherence, and many more. Atenolol and Olmesartan can be used as add-on therapy in managing hypertension with calcium channel blockers. Methodology: Blood pressure was monitored using Continous Ambulatory Blood pressure monitoring for 24 h and patients with blood pressure above 160 mm Hg and who are free from Atenolol or Olmesartan were included in the study. They were given with Atenolol or Olmesartan as an add-on drug to the existing other class of antihypertensive drugs. After a period of 2 weeks, their 24 h ambulatory blood pressure was measured again. A comparative data of both the blood pressure data was established. Results: The overall 24 hours ambulatory systolic blood pressure dropped from 179.32 ± 10.823 to 168.36 ± 13.991, and overall diastolic pressure dropped from 90.72 ± 13.743 to 81.32 ± 12.750. Similarly, the mean heart...
Read More
