Posted by admin on Oct 31, 2024 in |
Background/Aims: Polypharmacy, the concurrent use of multiple medications by a single patient, is common in modern healthcare to manage multiple comorbidities. While it helps address complex health conditions, it also brings significant challenges, such as increased risks of drug interactions and adverse effects, including the development of enteric ulcerlesions in the gastrointestinal tract. Methods: This research paper examines the complex relationship between polypharmacy and enteric ulcer formation through a comprehensive literature review. It investigates the mechanisms behind enteric ulcer development and the impact of polypharmacy on gastrointestinal physiology. Results: By analyzing the interactions and consequences of multiple medications on gastrointestinal health, this paper provides valuable insights for clinicians. These insights are aimed at optimizing medication regimens to reduce the risk of enteric ulcers and enhance patient outcomes. This paper aims to clarify the paradox of polypharmacy in relation to enteric ulcer formation. It highlights the complex interactions between multiple medications and gastrointestinal health, offering guidance for healthcare professionals. This guidance is essential for balancing the therapeutic benefits of polypharmacy...
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Posted by admin on Oct 31, 2024 in |
Background: Migraine is a common neurological disorder that presents significant challenges in treatment. Effective management is crucial due to debilitating nature of the condition. Aim: This meta-analysis aims to evaluate efficacy of both pharmacological and non-pharmacological interventions in managing migraine symptoms. Methods: The analysis included 13 studies focusing on various interventions for migraine management. Both pharmacological treatments and non-pharmacological approaches were assessed for their effectiveness. The efficacy of these interventions was measured using statistical methods, including weight difference, standardized mean difference (SMD), and mean difference (MD). Funnel plot analyses were conducted to check for publication bias. Results: Pharmacological interventions showed substantial efficacy compared to placebo, with a significant weight difference of 100.0%, a Z-value of 17.58, and a P-value of less than 0.00001. Non-pharmacological interventions also demonstrated significant effectiveness, with a Z-value of 11.62 and a P-value of less than 0.00001. However, there was considerable heterogeneity among the studies, as indicated by the following statistics: for MD, Chi² = 24.65 with 13 degrees of freedom and a P-value of...
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Posted by admin on Oct 31, 2024 in |
Oral Lichen Planus (OLP) is a rare chronic autoimmune mucocutaneous inflammatory disease characterized by painful oral lessions. Immunosuppressive agent Tacrolimus monohydrate is one of the effective therapy options for OLP as it possesses benefits such as greater safety and efficacy at lower doses over currently employed topical corticosteroids. From amongst its topical dosage forms, mucoadhesive oral gels of Tacrolimus monohydrate have advantages such as prolonged residence time, enhancement of absorption and therapeutic efficacy compared to the topical ointments. Considering this, the current work was aimed at formulating oral mucoadhesive gels of Tacrolimus monohydrate using PEG gel bases and mucoadhesive polymers. Firstly, non medicated mucoadhesive gels consisting of PEG gel bases and mucoadhesive polymers were formulated and evaluated for their appearance, feel, viscosity, pH, spreadability, tube extrudability and mucoadhesive strength. The combinations of PEG gel bases having PEG4000+PEG400 in 1:4, PEG 4000+PEG400 in 1:8 and PEG 6000+PEG400 in 1:4 were selected for incorporation of Tacroliimus monohydrate (0.1%) due to their ideal performance in maintaining the requisite gel characteristics at 400C...
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Posted by admin on Oct 31, 2024 in |
Objectives: Lovastatin is an antilipidemic medication categorised as a statin, which exhibits limited absorption when taken orally owing to its low solubility and inconsistent dissolution rate. The primary objective of this research was to improve the drug’s solubility and dissolving rate, as well as gain insight into its oral bioavailability. Materials and Methods: A precipitation-ultrasonication process was used to formulate Lovastatin nanosuspensions, with PVP k30, PEG 6000, and Tween 80 serving as stabilisers. The nanosuspensions that were created were analysed to determine their polydispersity index (PDI), particle size, surface shape, zeta potential, and in-vitro release rate. Results: The optimised formulation exhibited a particle size of 185±0.56 nm, a zeta potential of -27.8 mV, and a PDI of 0.042±0.32, indicating excellent stability. The morphological analysis revealed that the particles had nanoscale dimensions. The drug content was determined to be within the range of 73-94%. The in vitro analysis demonstrated a significantly accelerated drug release within a one-hour timeframe. Stability investigations revealed that the optimised formulation P2 exhibited greater stability when...
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Posted by admin on Oct 31, 2024 in |
New Schiff base metal ion complexes are synthesized and characterized by Mass, TGA, DTA, FTIR, UV-Visible, Conductivity, Magnetic properties, SEM, TEM EDX, and Elemental Analysis. The complexes have the general formula [ML2.H2O], where L=3-{(Z)-[(2-aminophenyl) methylidene] amino}-4-chlorobenzoic acid, and M= Mn (II), Co (II), Ni (II), Cu(II), Zn (II), Pt(II), and Pd(II). The Schiff base’s imino, amine, and carboxylic groups form a bond, the bands observed in the FTIR of the complexes. UV-Visible spectra of the complexes show that they are colour except for Zn (II) complexes. The parameters like the Nephelauxetic effect, covalence parameter b1/2, and co-valence (δ%) are calculated. The complexes are covalent. The central metal ions have eight coordination numbers, and the ligand behaves as bidentate. According to SEM TEM, EDX, and elemental analysis of the complexes, the size of prepared nanoparticles is 16-84 nm. The mass spectra of the ligand and complexes match the theoretically estimated values of Schiff bases and complexes. According to TGA and DTA complexes decompose when temperature rises, and two coordinated water...
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