Posted by admin on Jun 30, 2021 in |
Background: Wound infection occurs when one or more organisms invade the wound. Nosocomial infections are the most common hospital acquired infections responsible for mortality and morbidity. Multidrug resistance against bacterial strains is the most serious emerging situation in worldwide, warranting the search for other alternatives. In this regard Pentabark kashaya was developed which contains ingredients possessing antimicrobial, anti inflammatory, and wound healing activity. Materials and Methods: Antibacterial activity of Pentabarkkashaya (PK) was determined against three predominant bacterial strains one gram positive and two gram negative strain Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The sensitivity of the organisms were tested by both the agar well method and broth dilution method (MIC) and it was compared with the antibacterial activity of provide iodine solution 5%. Result: Pentabark kashaya showed antibacterial activity against all the test pathogens in both agar well and broth dilution method. The highest antimicrobial activity was observed against Escherichia coli and Pseudomonas aeruginosa in agar well diffusion method showed the inhibitory zone of 14 mm in both...
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Posted by admin on Jun 30, 2021 in |
Common chicory (Cichorium intybus L.) plant belonging to sunflower family primarily grown for its root which is used as a coffee substitute but is also widely used in folk medicine to treat various ailments ranging from wounds to diabetes. The plant is a good tonic cooling agent and is useful in headache, throat inflammation, immune stimulation, mutagenic, probiotic, hepatoprotective, antibacterial activity etc., and these actions are attributed to a wide range of phytoconstituents present in this plant. In the existing study, the total flavonoid and phenol content of methanolic extract of selected parts (leaves, root, and seeds) of Cichorium intybus L.was quantitatively estimated using aluminium chloride colorimetric method (as quercetin equivalent) and Folin-Ciocalteu method (as caffeic acid equivalent) respectively. The total phenolic contents varied from 1.94± 0.895 to 1.66± 0.506 mg/gdw. Total flavonoid contents were between 1.60± 1.69 to 1.37 ± 0.796...
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Posted by admin on Jun 30, 2021 in |
Dolutegravir sodium (DTG) is a poorly soluble antiretroviral drug that belongs to BCS class II approved by the FDA for treatment of HIV infections; however, DTG has several shortcomings, including low solubility in water, low oral bioavailability, hepatotoxicity, and instability in an acidic environment. After oral administration, 84% of the dose is excreted from the body in an unchanged form due to its poor solubility. To overcome the above mentioned difficulties, Nano Lipid Carriers (NLCs) are selected as a potential drug delivery system for the present research work. NLC suspension was formulated using melt emulsification sonication technique using a combination of solid lipid (8% w/v), i.e., Glyceryl monostearate (GMS), Gelucire 50/13, Dynasan 118, and liquid lipid Capmul MCM EP along with a blend of Tween 80 and Span 80 as a surfactant, Sodium cholate (0.4 w/v) as surface charge modifier and BHT (0.01%w/v) as a preservative. Response surface methodology using 23 factorial designs with three independent variables, that is, lipid concentration (A), surfactant concentration (B), sonication time (C) was...
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Posted by admin on Jun 30, 2021 in |
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v utilizing a Hibera C18 column which has dimensions of 100 × 2.1 mm, 1.8µ particle size and the flow rate of 1.0 ml/min. The detection system was monitored at 230nm wavelength maximum with 1.5 µl injection volume. The retaining time for trifluridine and tipiracil was achieved at 0.549 min, and 1.251 min. respectively. Tipiracil and trifluridine and their combined drug formulation were exposed to thermal, acidic, oxidative, photolytic, and alkaline conditions. The present method was validated as per the guidelines given by the ICH for specificity, accuracy, sensitivity, linearity, and precision. The developed method was highly sensitive, rapid, precise, and accurate than the earlier reported methods. The total run time was decreased...
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Posted by admin on Jun 30, 2021 in |
Background: Hyperpigmentation (HP) is a common dermatological disease. Indian population presents in a variety of dermatological pigmentation. Effects of Nutrients and metabolites factor are important for skin hyperpigmentation condition. Aims and Objectives: In this study, we aimed to evaluate the status of Haemoglobin, vitamin B12, Ferritin, and TSH levels in people with hyperpig-mentation from a different region of Aravalli district Gujarat, India. Materials and Method: A study based retrospective, prospective and Multi-centric study conducted at the dermatological outpatient clinics at Modasa, Vatrak, Ranasanarea of Aravalli district, Gujarat, India. In this, we studied a total of 70 hyperpigmented patients fulfilling with inclusion criteria. Hyperpigmentation patients correlate with serum vitamin B12; Ferritin, CBC, and TSH during a four-year period from June 2015 to May 2019 were included in the study. Those were diagnosed with following various examinations and tests. A detailed examination was performed with respect to skin hyperpigmentation. Clinical and laboratory data compare with normal control. Student t-test used for statistical analysis. Results: A total of 70 HP patients were investigated...
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