Posted by admin on Apr 30, 2021 in |
The main aim of the present study was to formulate and evaluate valacyclovir-loaded liposomes. A drug and excipient compatibility study was performed by FT-IR, and the study revealed that there was no interaction between drug and excipients. Liposomes are prepared by using two different methods, i.e., ether injection method and thin-film hydration method. Various formulations are prepared by varying the concentration of phospholipid and cholesterol. All formulations are evaluated for entrapment efficiency and in-vitro drug release studies. The optimized formulation showed the highest entrapment efficiency (96.51%) and highest drug release (84.21%). The optimized formulation was evaluated for FT-IR, SEM and particle size analysis, and zeta potential studies. The FT-IR study revealed that there is no interaction between drugs and excipients. The optimized formulation was found to be stable with zeta potential -40.9 mV and particle size of 67.4 nm with uniform distribution. The regression coefficient (R2 value) 0.966 indicating release as zero-order, where “n” value 1.212 states the mechanism as a super case-II transport mechanism. Stability studies were carried...
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Posted by admin on Apr 30, 2021 in |
The present study evaluates the antihyperglycaemic and antioxidant activity of the methanolic extract of Capparis decidua (CDMtE) fruits in streptozotocin (STZ) induced diabetic rats. Streptozotocin (50mg/kg body weight/) was injected intraperitoneally in rats to induce diabetes. The STZ-induced diabetic rats were treated with CDMtE (200 mg/kg body weight /day) for seven days. Biochemical analysis, toxicity studies, and histopathological studies were carried out to assess the antihyperglycaemic and antioxidant effects. Treatment with CDMtE (200 mg.kg b.wt/day) caused a significant decrease in fasting blood glucose and improvement in the serum insulin level of the diabetic rats. Antioxidant enzymes SOD and GSH activity was increased, and LPO levels of diabetic rats decreased after oral administration of CDMtE (200 mg/kg body weight/day). Histopathological studies showed significant recovery in liver architecture after CDMtE administration. Histopathological results suggest the antihyperglycaemic and antioxidant ability of CDMtE. This study supports the therapeutic potential of C.decidua fruits in the treatment of...
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Posted by admin on Apr 30, 2021 in |
Medicinal plants are considered to be the most important in the primary health care system of developing countries. The therapeutic properties of a plant depend upon the biochemical compounds present in the plant parts employed in the preparation of a medicine. Trichosanthes dioica Roxb. is being used as popular Ayurveda and Siddha medicine used to treat various diseases. Objective: The objective of this research was to carry out for identification of bioactive compounds from ethanolic extracts of leaf and fruit of Trichosanthes dioica Roxb. by Gas chromatography and Mass spectroscopy (GC-MS). Methods: The air-dried leaves and fruits were powdered and separately extracted with ethanol by using a Soxhlet extractor; then, each of the extracts was subjected to qualitative phytochemical analysis and further subjected to a GC-MS instrument. Results: The result of the qualitative analysis of plant extracts has a wide range of active phytocompounds such as alkaloids, flavonoids, glycosides, phenols, saponins, steroids, reducing sugar, tannins, and terpenoids. The GC-MS analysis, twenty two different phytochemical compounds were identified in T....
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Posted by admin on Apr 30, 2021 in |
Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The purpose of the current research work is to isolate the biopolymer from Phoenix dactylifera (date palm) and prepare mucoadhesive bio-flexy films loaded with Phenytoin. The isolated biopolymer was subjected to various physicochemical characterization procedures for analyzing the mucoadhesive and mucoretentive properties. The mucoadhesive and mucoretentive properties of isolated biopolymer were analyzed using the shear stress method and the MS mucoretentibility method. The formulated Phenytoin loaded bio-flexy films were evaluated for weight, thickness, folding endurance, swelling index, surface pH, tensile strength, etc. The in-vitro drug release studies were analyzed using the static MS diffusion apparatus. Phenytoin loaded with HPMC and sodium CMC was used as standard film, and then results were compared. The optimized bio-flexy films shows order PD6 > PD5 > PD4 > PD3 > PD2 > PD1 on the basis of percentage release. The percent release...
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Posted by admin on Apr 30, 2021 in |
Objective: To evaluate the effect of some counterfeit anti-obesity drugs that are not licensed by the Ministry of Health. Materials and Methods: 100 male rats were divided into 10 groups. The first group received a normal diet for two months. The second group received a high-fat diet (HFD) for two months; the third group received HFD for one month then returned to a normal diet. The remaining seven groups received HFD for one month then treated with Orlistat, Turbo slim (dose 1), Turbo slim (dose 2), African mango (dose1), African mango (dose 2), Slim factor (dose 1), and Slim factor (dose 2) respectively for an additional one month. Bodyweight, glucose, insulin, leptin, adiponectin, MCP-1, reduced glutathione, MDA, lipid profile, kidney, and liver functions were measured. Adipose tissue index, atherosclerosis index, HOMA-IR, and QUICKI were calculated. Results: Feeding with HFD induced a significant increase in body weight as well as insulin resistance, serum lipids, serum leptin, plasma MCP-1, and tissue MDA and a significant decrease in serum adiponectin and tissue...
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