Posted by admin on Jan 31, 2021 in |
Levocetirizine dihydrochloride is an orally active, third-generation non-sedative antihistamine used in the symptomatic relief of seasonal and perennial allergic rhinitis. It competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. The present work aimed to prepare mucoadhesive buccal films to deliver the drug in a controlled manner with a longer duration of action, which is beneficial in managing severe conditions of allergies. The semisolid casting method was used to prepare the film using different conc. of sago starch and glycerol (plasticizer) with a variation of heating time and heating temperature. The study clearly indicated the influence of heating time and concentration of sago starch on drug release profile. It was noticed that the rate of drug release increased with increased heating time and slowed as the concentration of polymer increased. Prepared mucoadhesive films were evaluated for parameters such as thickness, surface pH, swelling properties, tensile strength, drug content...
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Posted by admin on Jan 31, 2021 in |
Introduction: Laparoscopic surgery is one of the most important diagnostic and therapeutic tools in the present surgical era. Laparoscopic surgeries require insufflation of the abdomen with some gas; usually, Carbon Dioxide is called pneumoperitonium, which induces pathophysiologic changes that complicate anesthetic management. To prevent and counteract these effects, appropriate monitoring and pharmacological interventions are required. Material and Method: In an observational study, sixty (60) patients of ASA physical status I or II aged between 18-60 years of age, of either sex scheduled for elective laparoscopic surgeries under general anesthesia, were observed. Inj. Dexmedetomidine infusion and Inj. Propofol infusion started at a different dose. Results: Both the drugs maintain hemodynamic stability during laparoscopy but at the time of extubation propofol group showed rise in parameters while dexmedetomidine patients were calm. Dexmedetomidine without bolus, as infusion only does result in attenuation of hemodynamic responses. Omitting the bolus dose avoided the undesirable hemodynamic effects like bradycardia and hypotension. Conclusion: The infusions of a sedative dose of dexmedetomidine and propofol during laparoscopic surgery...
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Posted by admin on Jan 31, 2021 in |
Aim: The main of the study is to study the Effect of Various Polar & Non-Polar Extracts of Alstonia scholaris leaves in Different Models of Diabetic Nephropathy in Rats. Material & Methods: Leaves of selected plant was extracted by using various solvents, i.e., Pet ether, Dichloromethane, Ethyl acetate, methanol and water. All the extracts were screened for the presence of various active phytocompounds i.e., alkaloids, terpenoids, tannins, flavonoids and phenolic compounds etc. For the pharmacological studies, OECD guidelines were used for the toxicity studies, and 1/10th and 1/5th doses used for the entire study. All the extracts were evaluated by different diabetic nephropathy model. After an assessment of activity, various biochemical parameters were measured. Result: There was a significantly high level of blood urea nitrogen in diabetic nephropathy animals compared to the normal animals; 28 days treatment regimen showed a significant reduction in elevated urea level. Elevated serum creatinine level was observed in diabetic animals which were significantly reduced by treatment groups; the highest reduction was observed in extracts...
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Posted by admin on Jan 31, 2021 in |
The incidence of Inflammatory Bowel Disease (IBD) is now rising in developing countries and increasingly considered an emerging global disease. IBD is a chronic, intermittent disease. Symptoms of IBD varies from person to person and segment of the intestinal tract involved. IBD diagnosis depends on the various test, which requires blood testing, stool testing, endoscopy, biopsies as well as physical examination with patient history study. The most common side effects of antibiotics in the treatment of IBD are killing microflora with bacteria; hence it makes the condition worst rather than curing. Curcumin has many pharmacological such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity, which play an important role in mitigating in CD and UC in IBD. Monoammonium glycyrrhizinate (MAG) was recognized as a compound possessing antimicrobial properties, MAG tested many researchers using the agar diffusion method, which shows significant antibacterial activities against gram-positive (Bacillus subtilis, Staphylococcus aureus) as well as gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), MAG also decrease the permeability of intestine in IBD which inhibit autoimmune attack....
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Posted by admin on Jan 31, 2021 in |
Helichrysum petiolare is a herbal plant used in the Eastern Cape of South Africa to treat asthma, chest problems, colds, coughs, infections, diabetes, and high blood pressure. This study aimed to evaluate the phytochemical components and antioxidant activities of the acetone, ethanol, cold, and boiled aqueous extracts of H. petiolare. The phytochemical contents of the acetone, ethanol, and boiled and cold aqueous whole-plant extracts of Helichrysum petiolare were determined using standard phytochemical reaction methods. ABTS, DPPH, NO, and total antioxidant capacity assays were used to evaluate their antioxidant properties. This study showed the highest total phenolic content (212.963 mg/g) in the boiled aqueous extract, while the ethanol had the highest flavonoid (172.393 mg/g) and proanthocyanidin contents (65.855 mg/g). Alkaloids, flavonols, and saponin were highest in the acetone extract, while the cold aqueous extract had the lowest phytochemical content. Among the extracts, the boiled aqueous extract had the highest DPPH. + (IC50 0.02 mg/mL) and ABTS. + (IC50 0.07) inhibition capacities, while the ethanol extract exhibited the highest NO radical...
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