Posted by admin on Mar 31, 2021 in |
Medicinal plants are becoming globally recognized because of their acclaimed therapeutic potentials. This study evaluated the plasma glucose and serum lipid profile levels among university students consuming Glycine max (Soya bean) in Nnewi, Nigeria. A total of thirty (30) apparently healthy male subjects aged between 18 and 30 years were randomly recruited from medical students to serve as both test and control groups. Each subject was advised to abstain from soya bean and similar food consumption for a period of three weeks prior to the commencement of the study. Subsequently, in addition to their normal diet, each of the subjects was given 25 g of soya bean powder before breakfast daily for 30 consecutive days. 6 mls each of baseline and test samples (after an overnight fast) were collected at day 0 and 31 respectively from each subject for the determination of plasma glucose and lipid profile parameters (TC, TG, LDL-C, HDL-C, and VLDL-C) using standard laboratory methods. Results showed no significant alterations in the mean body mass index...
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Posted by admin on Mar 31, 2021 in |
Chlorpyrifos is one of the commonly detected pesticides found in food and water. Extensive use of it in agriculture and its persistence in the environment have raised public concern to overcome the pollution and toxicity problems. Exposure to chlorpyrifos poses several harmful effects to animal and human health. And the pathology in neurodegenerative diseases is mainly because of mitochondrial dysfunction. GSH depletion proceeding with mitochondrial dysfunction is therefore considered as the earliest triggering factor of neurodegeneration. In the present study using Drosophila melanogaster a fly model for human neurodegenerative disease, we investigated the effects of chlorpyrifos on glutathione, reactive oxygen species, mitochondrial Complex I, and Complex II activities. We found that chlorpyrifos generates reactive oxygen species, diminished the levels of reduced glutathione (GSH) concurrently increasing oxidized form of glutathione (GSSG), this preceded with inhibition of mitochondrial enzymes such as complex I and complex II activities, ultimately leads to motor dysfunction and death of Drosophila...
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Posted by admin on Mar 31, 2021 in |
Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the fruit of L. acutangula (50 and 100 mg/kg/p.o.) significantly (P < 0.001) reduced the blood glucose levels from 65.2–49.4 and 68–48 mg% 2 h after oral administration of fruit extract and also significantly lowered the blood glucose in STZ diabetic rats from 67–101 and 64–89.2 mg% 21 days after daily oral administration of the extract (P < 0.001). The results suggested that the aqueous fruit extract of L. acutangula has a potential hypoglycemic effect in diabetic rats and authenticates the folkloric use of the plant for the management and treatment of...
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Posted by admin on Mar 31, 2021 in |
Usage of incense smoke has aesthetic importance. But, studies have shown that incense smoke has oxides of carbon, nitrogen, sulphur, which has ill effects on human health. Polyphenol analysis showed the presence of phenol-like compounds in the water extracts of the incense. This study was conducted to understand the impact of exposure of cells to these types of smokes by performing viability test using squamous epithelial cells. Different methods followed to confirm the results, and the results of these studies showed that 80% of the squamous epithelial cells survived when exposed to smoke as compared to controls (no smoke treatment). Further studies were extended on the cell lines BEAS-2B (normal lung cells) and cancerous cells EB-3 cells. Results based on the catalase assay and microscopic studies show that incense smokes have a lethal effect on the normal cells while not showing any harmful effects on cancerous cells and these studies reproduced using trypan blue...
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Posted by admin on Mar 31, 2021 in |
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[6-chloro-2- methyl-4-oxoquinazolin -3(4H)-yl] benzoic acid as intermediate-II. This resulted in intermediate-II undergo mannich base reaction to produce novel quinazolinone derivatives (Q1 – Q16) on the reaction of formaldehyde with different aromatic amines. Sixteen different quinazolinone derivatives were synthesized. Structural assignments of these compounds have been made by elemental analysis, FTIR, 1H NMR, and mass spectral data. Among the synthesized compounds Q3, Q8, and Q 15 showed high anti-inflammatory activity against standard drug Diclofenac sodium. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory...
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