Posted by admin on Mar 31, 2021 in |
Malaria is a parasitic infectious disease transmitted through the bite of female Anopheles mosquitos. Every year, approximately 210 million Peoples are suffering from this dangerous disease, and around 440,000 individuals pass from this infectious disease. Recently, the Indonesia Ministry of Health declared that the malaria pre-elimination stage should be reached by 2020 and be free of malaria transmission by 2030 to achieve the goal of an Asia-Pacific free of malaria by 2030. So, this study focused on the discovery of novel anti-malarial and medication targets against malaria. The three-dimensional (3D) structures of PFHGPRT, HSHGPRT, and TCHGPRT were used for comparative docking study, while two inhibitors 6-(2, 2-Dichloro-acetamido) chrysene and GMP-2′, 3′-dialdehyde were used as a lead for designing and discovery of potential inhibitor of PFHGPRT with the help of various software. The three-dimensional structure (3D) of pfHGPRT (3OZF) and (4RAO) PfHGPRT was isolated from its intricate structure and was utilized for docking study, and comparably, HsHGPRT was isolated from its perplexing structure, and it also utilized for docking study....
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Posted by admin on Mar 31, 2021 in |
The present research work was intended to develop and characterize the transdermal adhesive patch of clozapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability as compared to oral formulation. Formulation prepared were evaluated for physicochemical characterization, FTIR, DSC, permeability enhancement potential by ex-vivo, and stability studies. The results of the optimized formulation showed peel strength of 411 ± 3.56 cN/cm, flux of 109.59 ± 1.59 (µg/h/cm2) and % drug content of 99.53 ± 0.42% which was stable up to six months in accelerated condition. The results of the study revealed that the developed transdermal patch of clozapine can be a promising alternative which provides effective management of schizophrenia in terms of improved patient compliance and bioavailability which in turn reduces the dosage frequency and hurdles associated with the caretakers and...
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Posted by admin on Mar 31, 2021 in |
The main objective of the study is to develop gelucire 44/14 based lapatinib ditosylate (LPT) SNEDDS for the improvement of solubility and drug release. Pseudo tertiary phase diagram constructed for varying oil, surfactant, and co-surfactant combinations. Fifteen LPT SNEDDS formulations were prepared with anticipated component ratios (gelucire 44/14, peceol, and capmul MCM) based on monophasic region are subjected to thermodynamic physical stability test. Formulations that cleared stability tests were evaluated for % transmission, drug content, and in-vitro drug release analysis. The optimized formulation analyzed for particle size and zeta potential, followed by FTIR and SEM analysis. Formulation F13 with a maximum drug release of 98.96% in 60 min higher than 38.90±3.25% of pure drug is considered an optimized formulation. The average particle size and zeta potential of the F13 were 72.5 nm and -13.4 mV, respectively. The FTIR and SEM studies do not indicate any drug excipient interaction and confirm uniform drug distribution. The formulation subjected to accelerated stability study is proved to be stable over a period of...
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Posted by admin on Mar 31, 2021 in |
Introduction: Reproductive organs are the major target of heavy metal toxicity; oxidative stress plays a vital role in induction of such toxicity. Toxicity due to chronic exposure to a low dose mixture of three heavy metal lead (Pb), cadmium (Cd) and arsenic (As) and ameliorative potentials of two antioxidant micronutrients selenium (Se) and zinc (Zn) were evaluated in male albino rats. Materials and Methods: The animals were divided into four equal groups: i) control, ii) metal mixture, iii) mixture plus Se and iv) mixture plus Zn treated groups; all animals received respective treatment for ninety consecutive days. Body weight, relative organ weights, haematological and serum biochemical parameters, sperm characteristics, Steroidogenic enzymes, serum testosterone level, oxidative stress parameter sand testicular histology were evaluated. Results: There were significant alterations in body weight, relative organ weight, hematological and serum biochemical parameters in mixture treated groups indicative of systemic toxicity. There was marked decline in male sexual parameters; changes in oxidative stress parameters revealed associated oxidative stress. Supplementation with both Se and Zn...
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Posted by admin on Mar 31, 2021 in |
There is a paucity of data on studies evaluating trace elements and antioxidant levels and susceptibility of offspring of diabetic parents to type 2 diabetes in Nigerian population. This study evaluated the serum level of some trace elements and antioxidants among apparently healthy individuals with a family history of type2 diabetes mellitus (FH-T2DM). This was a cross-sectional study involving 122 Students (aged between 18-30 years) consisting of 60 apparently healthy subjects with FH-T2DM and 62 apparently healthy subjects without FH-T2DM. Serum levels of Cr, Zn, Se, and Mn and catalase and superoxide dismutase of these subjects were measured using atomic absorption spectrophotometric technique and spectrophotometric technique, respectively. The plasma glucose, body mass index (BMI), waist circumferences, and a waist-to-hip ratio of these subjects were also determined using standard methods. Results from this study showed that mean fasting plasma glucose level was significantly higher (p=0.001); serum levels of Cr was significantly lower (p=0.04) while serum levels of Zn, Mn, Se, SOD and Catalase did not differ significantly (p>0.05) in those...
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