Posted by admin on Dec 31, 2020 in |
Thrombocytopenia, a condition in which platelet count decreases (<150-450 × 109/L), occurs as a result of clinical conditions such as viral infections or cancer or as a side effect of chemotherapy or it can be inherited, but if not treated on time it can be life threaten-ing. So, here we have evaluated the anti-thrombocytopenic potential of three plant extracts (aqueous extracts of Carica papaya and Azadirachta indica, methanolic extract of Andrographis paniculata) individually and their equal, unequal, half, and double proportionate combinations against carboplatin induced thrombocytopenia in mice. Thrombocytopenia has been induced successfully in all the treatment groups as well as in the disease control group, followed by a single intraperitoneal injection of carboplatin at the dose of 125 mg/kg of body weight. The extent of thrombocytopenia was the highest on day 7. Platelet count was significantly low in the disease control group (p<0.0001) compared to all other groups starting from day 7 to the end. All groups have responded to their respective treatment and have shown an increase...
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Posted by admin on Dec 31, 2020 in |
Psoriasis is a non-infectious, dry, inflammatory skin disorder. It results in patches of thick, red skin covered with silvery scales. Transdermal drug delivery is used to deliver drugs through the skin, but the skin is an effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. The simulation using the COMSOL software will help to treat the psoriasis skin in a non-invasive manner. The main objective is to create a psoriasis skin model that replicates skin psoriasis properties. Designing a psoriasis skin model using COMSOL Multi-physics software helps to understand the biomechanical properties of the skin when the transdermal drug and the permeation enhancer are delivered. Transepidermal water loss (TEWL or TWL) is one of the causes of psoriasis. It is the loss of water that passes from inside a body through the epidermis to the surrounding atmosphere through diffusion and evaporation processes. To reduce the Transepidermal water loss, the transdermal drug carriers like Liposomes, Niosomes, and Ethosomes are delivered...
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Posted by admin on Dec 31, 2020 in |
The nanoclusters are having different properties than their bulk material. Hence, the synthesis and applications of nanoclusters of metal oxides have received more attention. Out of many available methods for the synthesis of metal oxide nanoclusters, the electro-chemical reduction method is simple, cheap, and provides pure material hence preferred. The present study describes the synthesis of nickel oxide nanoclusters by electrochemical reduction method wherein the nickel-metal sheet was used as a sacrificial anode while platinum was used as an inert cathode. The electrolysis was carried out at varied current density for 2 h in aqueous solutions using tetrabutylphosphonium bromide (TBPB) as a capping agent. The nanostructure of the synthesized nanoclusters has been analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transforms infrared spectrometer (FT-IR), and UV-visspectro-photometer. The nickel oxide nanoclusters were screened for their antimicrobial potential against gram-positive and gram-negative bacterial strains of Staphylococcus aureus and Escherichia coli and found to have a broad spectrum of...
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Posted by admin on Dec 31, 2020 in |
Introduction: Currently used analgesic agents are opioids & NSAID. All of these are associated with certain adverse effects, so research in new potent herbal formulations is urgently needed. Therefore a polyherbal formulation from seven well-known herbs that had been already individually tested for its analgesic & anti-inflammatory property was prepared, thinking that synergistically it would act better. Aims & objective: To evaluate the analgesic & anti-inflammatory properties of polyherbal formulation (PHF) in Wister rats. Materials and Methods: Analgesic activity was evaluated by using Eddy’s hot plate method & acetic acid-induced abdominal writhing test. Anti-inflammatory activity was tested by using inj. carrageenan-induced hind paw edema test. 24 Wister rats were divided into four groups, viz. A to D. group A served as the control, B & C as test drug group & group D as standard. Results: PHF had shown a significant increase in the hotplate latency period (p<0.01) in a dose-dependent manner, indicating central analgesic property. PHF had also shown a significant reduction in acetic acid-induced abdominal writhes (p<0.01),...
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Posted by admin on Dec 31, 2020 in |
Cucurbita Maxima, commonly known as pumpkin, which belongs to the family Cucurbitaceae, have numerous bio-active compounds such as polyphenols, dietary fibers, carotenoids, and minerals. This seed possesses anti-inflammatory and anti-oxidant properties and can be used in the neuro regenerative effects. In the present paper, an attempt has been made to reveal the phytochemical screening, anti-oxidant, anti-inflammatory activity and GC-MS spectral analysis of the isolated fatty acids compound of the plant Cucurbita maxima. From the anti-oxidant and anti-inflammatory activity of the petroleum ether extract showed good activity and proceeded for isolation; six fatty acid compounds were isolated from the seed Cucurbita maxima and analyzed using GC-MS and NMR. From the analysis, 10 compounds were identified by comparing their retention time and peak area with that of literature and interpretation of MS. The majority of phytoconstituents were 9-octadecenoic acid (Z), Oleic acid, 2-oxo-Cycloheptanevaleric acid and 14-Methyl-13-oxa-15-aza-dispirob [5.0.5.3] pentadec-14-ene. Hence this study helps in the screening of many bioactive components for the treatment of many...
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