Posted by admin on Jan 31, 2021 in |
This paper examined the liquisolid compact method as one of the tools for greater dissolution of the practically water-insoluble drug famotidine (FM). Therefore, the model drug, FM, has been formulated as directly compacted tablets and liquisolid compacts and then investigated for in-vitro release properties at diverse dissolution circumstances. According to the method, it is possible to convert the liquid medications of water-insoluble drugs in the non-volatile liquid vehicles into reasonably compressible and flowing powders. The formulated systems have been evaluated in terms of the pre-compression factors like the Fourier-transform infrared spectroscopy (FTIR) analysis, flow features of the liquisolid system, differential scanning calorimetry (DSC), post-compression factors, including the content uniformity, hardness, friability and weight variation, disintegration test, in-vitro dissolution examinations, effects of the dissolution volume as well as pH on the drug release rate and approximation of the fraction of the molecularly dispersed drug in the liquid medication. Since, the liquisolid compacts revealed notably greater drug release rates in comparison to the direct compress tablets in diverse dissolution volumes and...
Read More
Posted by admin on Jan 31, 2021 in |
In recent years, the extensive use of antibiotics has resulted in their frequent detection in the effluent discharge of wastewater discharge plants (WWTPs). In this study, the feasibility of using Surfactant-Modified Kaolinite (SMK) to remove the antibiotic, Ciprofloxacin (CIP) from wastewater was evaluated from batch experiments. The batch adsorption system was utilized to evaluate the CIP removal efficiency at different contact times, SMK dosages, and CIP concentrations. The experimental data were analyzed by the Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich (D–R) isotherm models. R2 values of Langmuir and D–R isotherm models are higher than that of other models, and maximum monolayer coverage (qmax) was calculated as 61.82 mg/g. The separation factor of 0.495 indicated favorable sorption. Also, from the Freundlich isotherm model, the intensity of adsorption (n) that indicated favorable sorption was 2.954. The kinetic study of sorption indicates that the pseudo-second-order model provides a better correlation of the sorption data than the pseudo-first-order, confirming the chemisorption of CIP ions on SMK. The results showed that a significant increase in...
Read More
Posted by admin on Jan 31, 2021 in |
Many infectious diseases have been treated with natural medicine. Now, fungi metabolites continue to play a major role as a therapeutic medicine in many countries. The present study reveals the potentiality of filtrate of Aspergillus terreus and Cladosporium cladosporioides as antidermatophitic agents. Molecular identification of isolates fungi using DNA sequencing of EF4 and ITS4primerswere performed. The fungal filtrate of A. terreus and C. cladosporioides were prepared in Potato dextrose broth and Sabouraud dextrose broth media. Antidermatophitic activity of it was evaluated against Trichophyton mentagrophytes, Trichophyton verrucosum, Microsporum gallinae, Microsporum gypseum, Microsporum canis, Microsporum floccosum, Candida albicans, and Candida tropicalis using dry weight method. The results show that E. floccosum was the most sensitive for Sabouraud dextrose broth filtrate of A. terreus while M. gallinae was the most sensitive for Potato dextrose broth of A. terreus. The potato dextrose broth filtrate of A. terreus was further subjected to the determination of the Minimal inhibitory concentration using different concentrations. The minimal inhibitory concentration values of different extracts were found to be...
Read More
Posted by admin on Jan 31, 2021 in |
Gastrointestinal tract disorders occur due to an imbalance of gastric acid secretion and defensive factors. Histamine receptor blockers and proton pump inhibitors are the most prominent therapies in the treatment of GI tract disorders. Inhibition of the K+/H+ ATPase pump blocks the secretion of gastric acid (HCl) from the parietal cells. The adverse effects of currently available drugs have obligated the screening of herbs as potent alternate medicines. In addition, plants contain different phytoconstituents, which are responsible for increasing defensive mechanisms against GI tract ulcers. Herein, we screen for the inhibition of K+/H+ ATPase pump using the methanolic extract of Clerodendrum inerme leaves. The extract exhibited 62.9% of inhibition (250 μgm) in a dose-dependent manner with an IC50 of 20.560 μgm/ml. Omeprazole (0.2mg/ml) was used as a positive control for the study. GC-MS analysis confirmed the presence of Phytol, a diterpenoid, as a major constituent in the methanolic extract. Hence, terpenoids could be attributed to the hypoacidic activity by inhibiting K+/H+ ATPase enzyme....
Read More
Posted by admin on Jan 31, 2021 in |
Moringa oleifera is widely used in Asia and Africa as an anti-inflammatory, anti-diabetic, and cold agent. However, there are no Moringa medicines on the Russian pharmaceutical market; therefore, it is of interest for research as a promising source of raw materials and introduction to the State Pharmacopoeia of Russian Federation. This study was conducted to compare the characteristics of the authenticity of leaves from different regions. Moringa whole leaf from India and powder from Namibia were studied using macroscopic, microscopic, and qualitative chemical analysis. The results showed that there are both similarities and differences of characters depending on the area of collection of raw materials. A quantitative assessment of diagnostic signs was carried out; for the first time, trichomes and druses, as well as stomata. Qualitative phytochemical analysis revealed the presence of tannins, flavonoids, and saponins in both samples. It was established that the studied samples corresponded to pharmacopoeial requirements for authenticity indicators. A relatively larger number of calcium oxalate druses was found in the Indian raw materials. The...
Read More
