Posted by admin on Sep 30, 2024 in |
Aim: The aim of present work is to analytical estimation and process validation of conventional tablet dosage form of Meloxicam. Materials and Methods: Tablets were prepared by wet granulation method. Then coating is done as film coating. Results and Discussion: Melting point, pH of drug was measured in triplicate and mean was notedi.e.253°C, 3.9. The maximum absorption was found to be 350 nm by UV. Various tests like Angle of repose, Bulk density, tapped density, Carr’s Index and Hausner’s ratio are performed at blend stage. Dissolution test and assay is performed of all the three batches. A kinetics study is performed for all the three batches and the result was found satisfactory. Conclusion: Results of the performed tests are to be assessed & summarized to confirm that the procedures followed consistently meet its pre-determined specifications and quality attributes. No maximum variation is found in results. So, our product is...
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Posted by admin on Sep 30, 2024 in |
The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, Hausner’s ratio and IR studies. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time. The most satisfactory formulation F6 showed minimum disintegration time of 31 sec and release maximum amount of drug in shortest duration of time in 10 min. it was found to be stable during short term stability studies. Compatibility studies confirmed the absence of any interaction between Voglibose and the selected excipients. The optimized formulation exhibited excellent disintegration time and dissolution profile, meeting the pharmacopoeia requirements for MDTs. Furthermore, sensory evaluation revealed improved palatability compared to conventional...
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Posted by admin on Sep 30, 2024 in |
The local tribes have used Phyllanthus virgatus for Malnutrition, Contagious infections, Inflammations (Gond Tribe), Hepatitis, Cold, Stomach-ache, Gonorrhoea, Fever, Headache, and septic ailments (Chenchus and Yanadis), etc. The gold nanoparticles have a highly specific surface area, and their unique physiochemical characteristics include catalytic activities, optimal properties, antimicrobial activity, etc. Aqueous leaf extract of Phyllanthus virgatus is used to synthesize gold Nanoparticles. The confirmation of biosynthesis of gold nanoparticles was characterized using UV Spectrophotometer, with the maximum scale observed at 551nm. SEM and EDX characterized the morphology of Gold Nanoparticles used to detect the presence of the element gold. The synthesized Nanoparticles were observed to be roughly spherical with a range of 2-50 µm. The dynamic light technique measured the hydrodynamic diameter (28.7nm) and a Zeta potential (-18.6mV). The FTIR analogue shows that the functional group assigned as=C-H, C-C, O-H, –C=C- and –C=O capping agents. The synthesized nanoparticles have shown strong inhibitory action against pathogenic microbial Strains using the Disc diffusion method. Bacillus cereus exhibited more significant results than other...
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Posted by admin on Sep 30, 2024 in |
Background: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteraemia in the first month of life. Any newborn with bacterial sepsis is at risk of meningitis, but late onset sepsis(LOS) has been fairly associated with meningitis from 3% to 30%.Most common organisms causing neonatal meningitis in developing countries are Gram negative bacteria (GNB) like Klebsiella pneumoniae and Escherichia coli. Objective: To detect microbiological profile of CSF and blood culture and its Antibiotic sensitivity test (AST) in LOS. Methodology: All the Positive sepsis screen patients with clinical suspicion of LOS, CSF and Blood sample were taken for culture and AST and CSF analysis. Result: During the study period 150 neonates 49 (32.6%) were diagnosed with meningitis. 42 were positive for Gram staining of CSF. From 42, CSF culture was positive in 38(25.33%) Neonatal meningitis were more common in male (61.2%) in preterm (73.4%) and in low birth weight (<2500gms) babies (87.7%). 61(40.66%) shows blood culture positive. Klebsiella pneumoniae was the predominant...
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Posted by admin on Sep 30, 2024 in |
Heat stress disrupts the delicate thermoregulatory setup of human body, activating various molecular pathways (reduction in uric acid production via polyol-fructokinase pathway, elevated levels of reactive oxygen species (ROS) causing oxidative stress, intracellular calcium overload associated with mitochondrial dysfunction, and diminished nitric oxide (NO) causing vascular endothelial injury) that contribute towards Heat Stress Nephropathy (HSN).This study was designed to investigate the nephroprotective potential of Green Tea Extract (GTE) and Hesperetin (HES) in HSN. Mice subjected to heat stress (39.5oC for 30 minutes, twice a day for 10 days) along with 2, 4-Dinitrophenol (DNP) were used as a nephropathy model. Furthermore, pretreatment with GTE (50mg/kg; s.c) and HES (50mg/kg; s.c) were done simultaneously followed by heat stress procedure. Results demonstrated a significant improvement in kidney function, as evidenced by reduced levels of Blood Urea Nitrogen (BUN) and Serum Creatinine (sCr) in mice pre-treated with GTE and HES compared to heat- stressed animals. Moreover, this combination led to a decrease in Thiobarbituric reactive substances (TBARS) levels while enhancing Superoxide dismutase (SOD)...
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