Posted by admin on Mar 31, 2025 in |
The aim of present study was to develop microemulsion formulation of apremilast for the topical treatment of nail psoriasis, a challenging condition due to the nail’s dense structure limiting drug penetration. Apremilast, a PDE4 inhibitor, offers an effective systemic approach but faces bioavailability challenges and potential side effects when administered orally. To address these issues, apremilast-loaded microemulsion was formulated using oleic acid, Tween 80 and PEG 600, optimized through a Box-Behnken design. The resulting microemulsion exhibited desirable characteristics, including particle size, PDI, and zeta potential, indicative of stability and effective drug delivery. In-vitro studies revealed an 81.63% drug release over 24 hours, highlighting the formulation’s sustained release capabilities. Ex-vivo transungual permeation tests using goat hoof membranes further supported enhanced drug permeation to the target site, outperforming the pure drug suspension. These findings suggest that apremilast-loaded microemulsion can provide a more targeted, efficient, and safer alternative for nail psoriasis therapy, improving patient compliance through topical application. This novel approach has potential implications for enhanced nail disease management and future topical...
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Posted by admin on Feb 28, 2025 in |
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ranged from 275.9 nm to 846.5 nm, and a high homogenization speed of 15,000 rpm was crucial in achieving smaller particle sizes conducive to better bone cell attachment. The zeta potential of -18.8 mV suggested good stability and potential for enhanced interaction with osteoblasts. The optimized formulation F5 exhibited high drug loading (87.56 %) and entrapment efficiency (85.36 %), with FESEM analysis confirming their favorable characteristics for drug delivery. The drug release profile followed a sustained pattern, with 69.60 % of the drug released over 8 hours, adhering to the Higuchi model of quasi-Fickian diffusion. The antimicrobial efficiency tests showed that these nanoparticles could maintain similar inhibitory concentrations against S. aureus as the standard clindamycin phosphate solution, indicating effective drug...
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Posted by admin on Feb 28, 2025 in |
Uraria picta (family Fabaceae) is an important woody medicinal herb. This plant has been used in traditional systems of medicine for the treatment of various diseases. It is also used in an Ayurvedic formulation of “Dashmula”. The utilization of roots by uprooting the entire plant and the problems associated with seed germination threaten this plant in its natural habitat and cause a shortage of root material for Ayurvedic preparation. The present study aimed to assess seed viability and the influence of pre-sowing treatments on seed germination and seedling development of U. picta. The treatments were applied singly and in combination, including acid scarification (H2SO4), hot and rubbing with sandpaper, pre-soaking in gibberellic acid (GA3), and the application of cuttings to the seed coat followed by pre-soaking in distilled water. The significantly highest rate (90%) of seed germination and a higher proportion of strong seedlings were observed in the seeds treated with 95% H2SO4. The protocol developed for seed germination and seedling development can be applied for raising a large...
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Posted by admin on Feb 28, 2025 in |
Background: Plants for remedial applications are well known, realizing the pharmacological potentials of plants through analytical techniques. Asparagus racemosus is a well-known medicinal plant analyzed using biological approach. The present study was carried out to evaluate the antioxidant, ani-inflammatory, antibacterial effects and the possible bioactive compounds present in the chloroform, methanol and aqueous extract of A. racemosus plant. Methods: The whole plant was subjected to serial solvent extraction using chloroform, methanol, and aqueous. Phytochemical screening, total phenolic and total flavonoid contents were determined using standard methods and was followed by GCMS and FTIR for biological activity of compounds. The plant extracts were assessed for antioxidant activity by DPPH and FRAP assays, anti-inflammatory activity by protein denaturation method, and antibacterial activity by agar well diffusion method. Results: The phytochemical tests revealed the presence of phytochemicals like alkaloids, flavonoids, glycosides, triterpenoids, and saponins. The GCMS of whole plant chloroform, methanol and aqueous extract revealed the compounds that are rich in free radical scavenging activity and proven to be the best source...
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Posted by admin on Feb 28, 2025 in |
Discovering Novel MAO-B inhibitors is promising therapeutic strategy for Parkinson’s disease. The pharmacological effects of MAO-B inhibitor showed significant neuro-protection and improved motor function and reduced oxidative stress marker. In-silico molecular docking simulation to investigate the interaction between target protein (MAO-B Inhibitors) and revealing promising hits with high binding affinity and favorable interactions. Molecular docking and binding affinity were analyzed between protein MAO-B inhibitor with selected bioactive compounds and Synthetic drugs in order to find the most potential inhibitor against the target. Thus, the objective of this research can provide an insight comparision based prediction towards some bioactive compounds in Genus momordica species (folic acid, momordicin, Balsaminol-A, Karavilagenin-C, Beta carotene) and few synthetic drugs (Opicapone, Apomorphine, Selegiline, Rasagiline, Ladostigil Zonisamide, Safinamide, NSAID, RG-2833 (gene therapy drug) against MOA-B Inhibitors performed using Pubchem, ProteinDataBank, Biovia discovery studio and PyRx. This research focuses on docking between the potential bioactive compounds shows strong affinity towards the targeted MOA-B inhibitor protein to treat parkinson’s diseases compared to synthetic drugs. This study shows the...
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