Posted by admin on Jul 31, 2025 in |
Kinetics of oxidation of L-cysteine and DL- Methionine by potassium permanganate in alkaline medium was studied spectro-photometrically at room temperatue. The reaction was found to be of first order with respect to amino acid, zero order with respect to oxidant and fractional order dependence on Alkali. It was found that the rate of the reaction increases with increase in concentration of [OH-]. There is a good agreement between observed and calculated rate constant under experimental conditions. The activation parameters are computed with respect to the slow step of the reaction. Cysteine exhibits relatively consistent kinetic behavior than Methionine. The oxidation product of the reaction was found to be cysteine and Methionine sulfoxide. A plausible reaction mechanism has been proposed for the experimental...
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Posted by admin on Jun 30, 2025 in |
Background: Cognitive impairment is a serious problem, especially for the elderly. Cognitive impairment is often associated with neurological disorders and congenital diseases. The impact of central nervous system depressants (CNSDs) on cognition needs to be further investigated. Objective: This study aims to evaluate the relationship between CNSD use and cognitive impairment with neurological disorders and comorbidities, along with the severity of cognitive dysfunction. Materials and Methods: A prospective cross-sectional study was conducted over a 6-month period in a tertiary care hospital, including 129 patients aged 18 years and older. Cognitive function was assessed using a structured questionnaire and severity scales. Data on demographics, neurological disorders, medications, and comorbidities were collected from patient records and statistically analyzed. Results: Cognitive decline increased with age, particularly in patients aged 61+ years. Benzodiazepines were significantly associated with mild cognitive impairment. (22%, p = 0.02), while anti-convulsant and anti-Parkinsonian drugs had minimal impact. Stroke patients with comorbidities showed the highest rates of cognitive decline (25.3%, p = 0.01). Conclusion: The Results indicate that while...
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Posted by admin on Jun 30, 2025 in |
The research aims to do a pre-formulation study on powdered drug of Dexketoprofen Trometamol to know its physical, chemical and pysico-chemical properties. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely used for pain relief and inflammation reduction. Dexketoprofen Trometamol, a highly soluble Non-Steroidal Anti-Inflammatory Drug (NSAID) is tromethamine salt of Dexketoprofen (Active enantiomer of ketoprofen). It works by blocking the action of cyclo-oxygenase in the body. It is widely used for its analgesic and anti-inflammatory properties in the treatment of acute pain and musculoskeletal disorder and post operative pain. Dexketoprofen trometamol was subjected to microscopy, X-ray diffraction, UV-Visible spectroscopic analysis and FTIR spectroscopic analysis for its properties to study. The drug was also subjected to some physical examination to examine its organoleptic properties and subjected to some chemical analysis to determine its chemical properties. The research showed micro-sized particle size ranges (1-10µm) of drug with its hydrophilic nature and UV analysis of drug showed its λ max peak of absorbance at 259nm. The X-ray diffraction study and Melting point study showed...
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Posted by admin on Jun 30, 2025 in |
Background: Childbirth is a multi-stage process, and the postpartum period holds significant implications for maternal health. The third stage of labour, when the placenta detaches, is the most dangerous for women because of excessive bleeding (postpartum hemorrhage or PPH). This is often caused by the uterus not contracting properly (uterine atony). Thus, there’s a well-established practice called active management of the third stage that helps to prevent these complications. Objectives: To assess the efficacy and safety of carboprost in active management of third stage of labour. Methodology: Sixty parturient were enrolled in a study. Following the delivery of the baby’s anterior shoulder, these parturient received a single intramuscular injection of 125 microgram of carboprost. The primary outcomes assessed were the duration of the third stage of labour, the amount of blood loss, and the incidence of postpartum hemorrhage (PPH) Results: This study group experienced an average third stage of labor duration of 5.25 ± 1.73 minutes, accompanied by an average blood loss of 157.41 ± 49.43 ml and the...
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Posted by admin on Jun 30, 2025 in |
Background and Objectives: The aim of the study is to evaluate the comparison based on cost effectiveness of inhalers used for asthma managements. The study utilized prospective interventional sampling approach and included Patient above 18 years and below 60 years, outpatients and In-patients, Asthma patients with comorbid conditions and excluded Pregnant and lactating women, unwilling patients, Subjects with communication problem, terminally ill/ ICU patients, Patient having insurance. Results: The incidence of asthma was seen mostly in the patients of age category 48 years and older (30.6%). Most of the patients were from the upper middle category (59%). After giving proper counselling to the patients, it was clearly evident that there will be improvement in adherence (76.4%). The subjects (47.2%, n=68) were found to be highly satisfied with the treatment provided to them by the physician. The PFT values after adherence were found to be 84.118±12.647. The most common inhaler device was found to be (61.1%, n=88). The mean drug cost for Budesonide/Formoterol was found to be less compared to...
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