Posted by admin on Nov 30, 2024 in |
Flavonoids are a class of Polyphenolic compounds found abundantly in plants. This study employs computational methods to predict the binding affinities and interaction patterns of selected flavonoids with the adenosine A2A receptor, Monoamine oxidase B (MAO-B enzyme), and Catechol-O-Methyltransferase (COMT enzymes). The docking simulations were performed using software packages such as iGEMDOCK which utilizes molecular mechanics algorithms to simulate the docking process. Visualization of the docking results was conducted using molecular visualization tools such as Drug Discovery studio (BIOVIA), enabling the analysis of binding modes and interactions between flavonoids and their respective protein targets. This visualization aids in identifying key amino acid residues involved in ligand binding, as well as understanding the structural basis of Ligand-receptor interactions. The findings highlight specific flavonoids that exhibit favourable binding affinities and interactions with the targeted neurochemical receptors and enzymes. Such insights are crucial for guiding further experimental validation and optimization of flavonoid-based compounds as potential therapeutic agents for neurological...
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Posted by admin on Nov 30, 2024 in |
Background: Obsessive-Compulsive Disorder (OCD) is a chronic mental health condition that significantly impairs an individual’s quality of life (QOL), affecting physical, psychological, social, and environmental well-being. In India, particularly in Northern regions, OCD patients face unique socio-cultural and healthcare challenges, which may exacerbate the impact of the disorder. This study aims to assess the QOL outcomes of OCD patients receiving treatment at a tertiary care psychiatry outpatient department in Northern India. Methods: A prospective observational study was conducted at King George’s Medical University, Lucknow, involving 33 patients diagnosed with OCD, aged 18-60. The WHOQOL-BREF questionnaire was used to assess QOL across four domains: physical health, psychological health, social relationships, and environmental factors. Patients were followed up at 1, 3, and 6 months. Statistical analysis was performed using SPSS version 26, and significant differences were identified using ANOVA. Results: The study found significant improvements in specific domains of the WHOQOL-BREF, particularly in social functioning and psychological well-being, following treatment interventions. The results suggest that pharmacological and psychotherapeutic treatments contribute to...
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Posted by admin on Nov 30, 2024 in |
Introduction: Hyperlipidemia, characterized by elevated lipid levels, is linked to increased cardiovascular disease risk. This study explores whether hyperlipidemia heightens the likelihood of cardiac arrest, stemming from its role in atherosclerosis and coronary artery disease. The objective was to determine if individuals with hyperlipidemia face a higher risk of cardiac arrest, underscoring the importance of managing lipid levels for cardiovascular health. Materials and Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. 20 randomized controlled trials (RCTs) were included, totaling 12,146 participants with hyperlipidemia and comorbidities such as atherosclerosis and coronary artery disease. Quality assessment utilized the Newcastle-Ottawa Scale (NOS). Odds ratios (OR) and risk ratios (RR) were computed for meta-analyses, assessing the association between hyperlipidemia and cardiac arrest risk. Publication bias was evaluated through funnel plots. Results: The meta-analysis revealed a significant association between hyperlipidemia and cardiac arrest risk. Both OR (0.51) and RR (0.77) indicated odds of slight cardiac arrest among individuals with hyperlipidemia as per forest plot analytical data is OR (Chi² of 31.14...
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Posted by admin on Nov 30, 2024 in |
Objective: The present study aimed to develop and evaluate herbal cosmetic cream by incorporating standardized Ocimum basilicum leaf extracts to exert its anti-oxidant potential as anti-wrinkle properties. Methodology: The hydro-alcoholic and aqueous extracts were prepared and standardized through high-performance thin-layer chromatography studies using the mobile phase ethyl acetate – acetic acid- formic acid- water (100:11:11:26 v/v/v/v) along with the standard rutin. Then, the anti-oxidant potential of the extracts were analysed through in-vitro DPPH free radical scavenging assay. Further, the formulations were developed using hydro-alcoholic and aqueous extracts (F1 to F6). The formulations were analysed for stability, physical characterization, HPTLC studies and anti-bacterial properties. Results: The studies resulted the spot at Rf 0.40 and the calibration showed the linear relationship with the r2 value 0.99716 in the concentration ranging from (400-1500) ng per spot. The anti-oxidant activity resulted in a percentage inhibition of 84.62% for hydro-alcoholic extract and 71.23% for aqueous extract, comparable with the standard ascorbic acid, which was 94.02%. The cream was characterized by its bloom strength, extrusion,...
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Posted by admin on Nov 30, 2024 in |
Background: Fungi have emerged as major cause of human diseases since early 1980s. In hospitalized patients with serious underlying diseases and those having immunocompromised state, opportunistic fungal infections bring about a substantial increase in morbidity and mortality. Aim and Objectives: Isolation and characterization of Candida species in ICU patients of Dr. Susheela Tiwari Government Hospital, Haldwani, Uttarakhand. Materials and Methods: A prospective observational study was conducted for two years from Nov 2015 to Oct 2017 and 2323 samples were collected from suspected cases of Candida infection, admitted in ICU of Dr. Susheela Tiwari Government Hospital, Haldwani. Identification of Candida species was done by standard laboratory processes. Results: In the present study, out of 2323 clinical specimens received from different ICU’s, 104 samples were found positive for Candida species. Majority of the patients were in the age group ˃ 60 years (24.04%). We observed that Non-albicans Candida (NAC) species (67.3%) were more frequently encountered than C. albicans (32.7%). Among NAC, C. tropicalis was the most common species (61.4%). Maximum numbers...
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