Posted by admin on Sep 30, 2024 in |
Objectives: Moringa oleifera has enormous attention as the ‘natural nutrition of the tropics and an essential food commodity. Antioxidants important in deactivating free radicals having damaging role on biological cells. Polyphenolic compounds are the most prevalent antioxidants seen in plants. Present study aims to evaluate the antioxidant and antitumor effect of ethanolic leaf extract of Moringa oleifera (ELMO) against Ehrlich’s ascites carcinoma bearing Swiss albino mice. Materials and Methods: 500 mg/kg body weight of ELMO was administered once in a day about 15 days after 24hrs of tumour inoculation. In mice treated with ELMO we observed decreased body weight, abdominal circumference and tumour volume, when compared to Ehrlich’s ascites carcinoma control mice. We also observed in mice Treatment with ELMO decreased levels of lipid peroxidation (LPO) and increased levels of (GSH), and superoxide dismutase (SOD). Results: Mice treated with 500mg/kg body weight of ELMO have shown a significant decrease in both the protective and curative group of body weight, tumour volume, and abdominal circumference compared to the Ehrlich’s ascites...
Read More
Posted by admin on Sep 30, 2024 in |
Background: Hepatitis B (HB) is a global public health issue that needs to be addressed. This study aims to assess Knowledge, Attitude and Practice (KAP) towards Hepatitis B and its vaccination status among undergraduate medical students of Govt. Medical College, Almora in Kumaon region of Uttarakhand. Material & Methods: An institution-based cross-sectional study was conducted at Government medical college, Almora in which 299 students were enrolled. Data was collected via Google form link. Results: In the present study, out of 299 students, 104 were male and 95 were females. It was found that students had good knowledge regarding Hepatitis B virus but there was a bit gap between knowledge, attitude and practice towards hepatitis B virus and its vaccine that need to be addressed. Conclusion: In the present study, near about half of the participants had good knowledge, attitude, and practice (KAP) regarding Hepatitis B. Education regarding Hepatitis B need to be imparted for prevention and timely...
Read More
Posted by admin on Sep 30, 2024 in |
Dental caries is a persistent disease characterized by acid damage to tooth enamel, which begins with the formation of biofilms on the tooth surface. Streptococcus mutans secretes glucosyltransferase, which enables the synthesis of extracellular glucan polymers using ingested starch within the oral cavity, ultimately resulting in acid production, a contributing factor to tooth decay. In this study, we conducted a preliminary screening and partial purification of glucosyltransferase enzymes and evaluated their inhibitory activity against selected plant extracts. We screened 36 isolates of Streptococcus mutans for glucosyltransferase enzyme production and identified the SM-18 isolate as having the highest enzyme activity and protein concentration which was selected for further study. Further enzyme optimization studies revealed that the optimal conditions for enzyme activity were pH 6.5, a temperature of 40°C, an incubation time of 18-19 hours, and a substrate concentration of 70 g/L. The extracted enzyme was precipitated at 70% using the ammonium sulphate precipitation method and had a molecular weight of approximately 65 kDa. We also analyzed the inhibitory effects of...
Read More
Posted by admin on Sep 30, 2024 in |
Arq-e-zeera, a distillate preparation of mainly Cuminum cyminum (Safed zeera), Bunium persicum (Shahi/kala zeera), Trachyspermum ammi (Ajwain) seeds, and Zingiber officinale (Adrak) rhizome isclinically used for declining obesity. Numerous trace elements, including calcium, magnesium, manganese, iron, zinc, and salt, are abundant in these herbs. These herbs have been observed to have diverse activities, notably antioxidant, antimicrobial, antidiabetic, hepatoprotective, anti-inflammatory and against gastrointestinal disorders. Major compounds of Arq-e-Zeera, as identified by GCMS and GC analysis, include thymol, limonene, terpinene, Cuminaldehyde, carvacrol, cymene, 1-phenyl-propanol, and 4-ethyl-3 non-5 yne, among other chemical components. Furthermore, because no or less evidence of their toxicity has been found in the literature, these are employed as aromatic ingredients and to enhance the taste, flavor, texture, and therapeutic benefits of many traditional cuisines. This review provides updated information on the morphological and taxonomical classification, chemical structures, experimental models, and methodologies employed in investigating the numerous activities and chemicals identified from the four primary constituents of...
Read More
Posted by admin on Sep 30, 2024 in |
Introduction: Aedes mosquitoes are responsible for transmitting several life-threatening diseases worldwide, which poses a significant societal burden. It is crucial to control these mosquito vectors to prevent the transmission of diseases. In this regard the present work focused on phytochemical screening and larvicidal activity on the whole plant of Barleria cuspidate ethanolic extract. Methods: Ethanolic extract of Barleria cuspidata was prepared by successive extraction using the maceration method. The larvicidal activity of different concentrations (20 mg/ml, 40 mg/ml, 60 mg/ml, 80 mg/ml, and 100 mg/ml) was assessed against 4th instar Aedes aegypti. Mortality rates were recorded after 24 hrs and 48 hrs to evaluate the larvicidal activity against Aedes aegypti. Results: The phytochemical screening of Barleria cuspidata ethanolic extracts revealed the presence of Alkaloids, Saponins, Flavonoids, Steroids, and Tannins. At a concentration of 100 mg/ml, the extract demonstrated the highest inhibitory effect, with mortality rates of 84% and 93% observed at 24 and 48 hours respectively. In contrast, no mortality was observed in the control group, indicating that the observed effects were specifically due to the extract. The LC50...
Read More
