Posted by admin on Nov 30, 2020 in |
Objective: Arjunarishta is an important Ayurvedic formulation with chief ingredient Arjuna (Terminalia arjuna), which is excellent “Hrudya” Dravya. It nourishes & strengthens heart muscles & promotes cardiac functioning by regulating blood pressure and cholesterol level. This study aims to established quality parameters for standardization of Ayurvedic formulation “Arjunarishta” on the basis of various techniques viz. Physico-chemical screening, Chromatography & IR Spectroscopy. Method: Conventional analysis such as Organoleptic tests, pH, Alcohol content, Brix, and Specific gravity was done. Chromatographic analysis was performed to estimate Arjungenin, Ellagic acid, and Gallic acid using High-Performance Thin Layer Chromatography (HPTLC). IR fingerprint was done using Fourier transform infrared (FT-IR) spectrometer. Result: The above analysis showed the pH of tested formulation ranges between 3.0-5.0, Brix 25-30%, and Alcohol content 6-10% v/v. Organoleptic tests confirmed characteristic odor of self-generated alcohol with sweet, astringent & slightly bitter taste. HPTLC analysis confirmed the presence of Arjungenin, Ellagic acid, and Gallic acid. FT-IR reveals unique transmittance spectra in the range of 4000 – 600 cm-1. Conclusion: This study can...
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Posted by admin on Nov 30, 2020 in |
The extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The Elastosomes are prepared using thin-film hydration technique using edge activators like Span 80, Tween 80, and Brij 30. The prepared elastosomes are evaluated for entrapment efficiency percentage (EE %), particle size (PS), polydispersity index (PDI), zeta potential (ZP), deformability index (DI), drug release study, and permeation study. EF-10 was regarded as the optimized formulation with all the desired characteristics. The optimized formulation (EF-10) resulted in better prolong drug release and sustained therapeutic action as compared to the marketed...
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Posted by admin on Nov 30, 2020 in |
Increasing severity of the disease osteoporosis in postmenopausal women with long term exposure to pharmacotherapy has spurred interest in the development of using food as medicine and phyto-pharmacotherapy. We examined the effect of n-hexane crude leaves extract and its nanoparticle formulation of Sesbania grandiflora in cell proliferation and bone mineralization at different concentrations in Saos-2 cell line. Osteogenic differentiation and cell viability of Saos-2 cells were quantified by monitoring alkaline phosphatase activity and MTT assay. HPLC analysis confirms the presence of bioactive compound α tocopherol. It was found that the concentrations 10 µg & 20 µg/100 µL significantly induced cell proliferation (p<0.05), and the expression of ALP (p<0.01) was not inhibited by the presence of the bioactive compound. Our data suggest that S. grandiflora nanoparticles affect the Saos-2 cell health in higher dose concentration and will be a good natural herbal medicine candidate for the treatment of osteoporosis at lower dose concentration. Further research is required to gain insight into the plant bioactive compounds and the molecular mechanism involved...
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Posted by admin on Nov 30, 2020 in |
The current study was aimed to estimate the ameliorative potential of Moringa leaf extract (MLE) against the toxicity of Imidacloprid (IMC) on hepatic biomarkers in zebra fishes, Danio rerio after acute exposure. To analyze liver biomarkers, 20 fishes were randomly selected and divided into four groups. Group- I served as control, Group- II received MLE- 12 ml/l , Group III- treated with 24 h LC50 of IMC (0.423 ml/l), Group- IV received 0.423 ml/l of IMC + 12 ml/l of MLE. The same protocol was implemented by taking 96 hrs LC50 of IMC (0.270 ml/l) and MLE (10 ml/l). At the end of the experiment, liver was dissected out, homogenized, and centrifuged separately to collect supernatant for enzyme analysis. The activity of ALT, ALP, LDH, and GGT were increased in IMC exposed fishes after 24 and 96 h exposure periods, whereas protein contents were decreased. The AST activity was decreased after 24 h and increased after 96 h exposure period. Administration of MLE along with IMC, reversed the impact...
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Posted by admin on Nov 30, 2020 in |
The aim of the present study was to investigate the possible role of Nigella sativa L. seeds extract on fluoride, aluminum and their combination induced reproductive toxicity in Swiss albino male mice. Nigella sativa L. known as black seeds is used as a form of traditional medicinal plant. Fluoride and aluminum are omnipresent metals and are tremendously used in industries, pharmaceuticals, and food additives. The combination study was planned as the two metals co-exist in the environment. The exposure of the combination of metals may cause a hazardous effect on different systems of the body, especially the male reproductive system. The experimental design of the study consisted of different groups. Group 1: control, Group 2: NaF treated (10 mg/kg), Group 3: NS with NaF treated (300 mg/kg + 10 mg/kg), Group 4: AlCl3 treated (100 mg/kg), Group 5: Nigella sativa with AlCl3 treated (300 mg/kg + 100 mg/kg), Group 6: NaF + AlCl3 treated (5 mg/kg + 50 mg/kg), Group 7: Nigella sativa with NaF + AlCl3 treated (300...
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