Posted by admin on Dec 31, 2020 in |
Introduction: Human Norovirus (HuNoV) is the major cause of acute gastroenteritis in pediatric populations, accounting for approximately 18% of cases worldwide. The aim of this study was to determine the prevalence rate and characterization of genogroup in the pediatric population with gastrointestinal disease. Materials and Methods: A total of 205 fecal specimens were taken from children below 15 years of age with acute gastroenteritis disease. Samples were collected from the pediatric department of Sanjay Gandhi Post Graduate Institute of Medical Sciences, Luck now. RNA was extracted from fecal specimens and screened for Norovirus GI and GII genogroups using real-time PCR. Results: The overall rate of Norovirus infections was 23 (11.2%). Among patients positive for Norovirus, 17(74.0%) were identified as GII genogroup, and 6 (26.0%) were identified as GI genogroup. Conclusion: The majority of Norovirus associated viral gastroenteritis cases among children were attributed to GII genogroup. Younger patients were at more risk of acute gastroenteritis. As the viral transmission was evident by the oral-fecal route, the high positivity of clinical...
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Posted by admin on Dec 31, 2020 in |
Marine carbohydrates play a crucial role in drug development and disease eradication as it is suggested as a promising bioactive material for its various properties. Seaweeds are the marine macroalgal source that contains a large amount of sulfated polysaccharides. Sargassum wightii (S. wightii) is one of the seaweed which possesses a wide range of pharmacological actions. The aim of the present work is to qualitatively quantitatively analyze the phytochemical substances and screen the antibacterial activity of S. wightii. The study is accomplished with chloroform and methanolic extracts of S. wightii. Among this, methanolic extract of S. wightii shows the presence of more phytochemicals and a substantial antibacterial activity. Quantitative analysis showed the presence of flavonoid content more. Antibacterial activity was more for gram-negative bacteria. Analysis of phytochemical substances and antibacterial activity determination reflected significant results. Hence further observations and studies on this macroalgae could bring out promising results in the future for the welfare of...
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Posted by admin on Dec 31, 2020 in |
According to Iranian traditional Medicine (ITM) “Monzej” es are applied to mature and eliminate abnormal humor, correct the abnormal temperament and promote the formation of normal humor, restoring the functions of all organs and the natural body force. “Monzej-e-balgham” (applying the above functions on abnormal phlegm, called “Balgham” in ITM, is used to evacuate morbid matters produced due to excess or putrefaction of phlegm by maturing and eliminating the abnormal “Balgham”, leading to control the development of many diseases in human body like gastrointestinal disorders (poor digestion, sour burp and reflux), Alzheimer’s disease, stroke, epilepsy, hemiplegia, facial palsy, asthma, bronchitis, atherosclerosis, vitiligo and impotency. Regarding the definition of phlegm in traditional medicine and the characteristics of mucus, it can be argued that one of “Balgham” type could be the secretions of the gastrointestinal cells or mucus. Due to this similarity, it is possible to alter body’s mucus with the help of a “Monzej-e-balgham”. So, in this research, the effect of tablet and syrup formulations of “Monzej-e-balgham” on stomach mucus...
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Posted by admin on Dec 31, 2020 in |
Ibuprofen has a higher dose (2000-2400 mg/day) that leads to several adverse effects like stomach upset, headache, bloating, hyperacidity, diarrhea, nausea, constipation, mild heartburn, ringing in your ears, vomiting and blurred vision. Piperine is a natural alkaloid obtained from piper species, principally from Piper longum and Piper nigrum (Family: Piperaceae). Piperine demonstrates excellent bioavailability Enhancing activity of different xenobiotics. Here in this study, the synergistic effect of Piperine and its synthesized derivatives was studied. Ibuprofen (10 mg/kg), in combination with Piperine and its derivatives (5a-5d) (10 mg/kg, were administered to Wistar rats, and the pharmacokinetic parameters were estimated. Thus, the study concludes that the presence of 5a significantly increases the absorption and reduces the elimination of the drug from the...
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Posted by admin on Dec 31, 2020 in |
Cucumis melo var agrestis (CMA) is belongs to the family of Cucurbitaceae. This plant is also known as wild musk melon it is widely distributed in the coastal areas. Many of the Cucumis species were reported as antioxidants, but there is no report on the antioxidant activity of CMA. The present study is aimed to evaluate the phytochemical analysis and antioxidant activity of different parts (leaves, stem, fruit, seed, flower, and root) extract of Cucumis melo var agrestis. The phytochemical screening confirms the presence of alkaloids, flavonoids, tannins, carbohydrates, saponins, glycosides, proteins, and amino acids in all extracts except Seed extract of CMA (SECMA), Fruit extract of CMA (FRCMA), and Flower extract of CMA (FLCMA) absence with tannins and FLCMA, a Root extract of CMA (RCMA) absence with saponins. Fruit extract of CMA (FRCMA) has the lower IC50 value for DPPH, ABTS, FRAP, and Phosphomolybdate assay when compared with all other extracts, and also the FRCMA possess higher phenolic and flavonoid content and also its activity is a nearby...
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