Posted by admin on Dec 31, 2020 in |
According to Iranian traditional Medicine (ITM) “Monzej” es are applied to mature and eliminate abnormal humor, correct the abnormal temperament and promote the formation of normal humor, restoring the functions of all organs and the natural body force. “Monzej-e-balgham” (applying the above functions on abnormal phlegm, called “Balgham” in ITM, is used to evacuate morbid matters produced due to excess or putrefaction of phlegm by maturing and eliminating the abnormal “Balgham”, leading to control the development of many diseases in human body like gastrointestinal disorders (poor digestion, sour burp and reflux), Alzheimer’s disease, stroke, epilepsy, hemiplegia, facial palsy, asthma, bronchitis, atherosclerosis, vitiligo and impotency. Regarding the definition of phlegm in traditional medicine and the characteristics of mucus, it can be argued that one of “Balgham” type could be the secretions of the gastrointestinal cells or mucus. Due to this similarity, it is possible to alter body’s mucus with the help of a “Monzej-e-balgham”. So, in this research, the effect of tablet and syrup formulations of “Monzej-e-balgham” on stomach mucus...
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Posted by admin on Dec 31, 2020 in |
Ibuprofen has a higher dose (2000-2400 mg/day) that leads to several adverse effects like stomach upset, headache, bloating, hyperacidity, diarrhea, nausea, constipation, mild heartburn, ringing in your ears, vomiting and blurred vision. Piperine is a natural alkaloid obtained from piper species, principally from Piper longum and Piper nigrum (Family: Piperaceae). Piperine demonstrates excellent bioavailability Enhancing activity of different xenobiotics. Here in this study, the synergistic effect of Piperine and its synthesized derivatives was studied. Ibuprofen (10 mg/kg), in combination with Piperine and its derivatives (5a-5d) (10 mg/kg, were administered to Wistar rats, and the pharmacokinetic parameters were estimated. Thus, the study concludes that the presence of 5a significantly increases the absorption and reduces the elimination of the drug from the...
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Posted by admin on Dec 31, 2020 in |
Cucumis melo var agrestis (CMA) is belongs to the family of Cucurbitaceae. This plant is also known as wild musk melon it is widely distributed in the coastal areas. Many of the Cucumis species were reported as antioxidants, but there is no report on the antioxidant activity of CMA. The present study is aimed to evaluate the phytochemical analysis and antioxidant activity of different parts (leaves, stem, fruit, seed, flower, and root) extract of Cucumis melo var agrestis. The phytochemical screening confirms the presence of alkaloids, flavonoids, tannins, carbohydrates, saponins, glycosides, proteins, and amino acids in all extracts except Seed extract of CMA (SECMA), Fruit extract of CMA (FRCMA), and Flower extract of CMA (FLCMA) absence with tannins and FLCMA, a Root extract of CMA (RCMA) absence with saponins. Fruit extract of CMA (FRCMA) has the lower IC50 value for DPPH, ABTS, FRAP, and Phosphomolybdate assay when compared with all other extracts, and also the FRCMA possess higher phenolic and flavonoid content and also its activity is a nearby...
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Posted by admin on Dec 31, 2020 in |
The dried leaves of Merremia emarginata Burm. F were screened for antitubercular, cytotoxic, and anti-inflammatory activities. The antimycobacterial activity of compounds was assessed against Myco-bacterium tuberculosis using microplate Alamar Blue assay (MABA), and the cytotoxic activity was studied on Hela (Human cervical carcinoma), MCF-7 (Human breast carcinoma) cell lines. A prenylflavonoid, 8-prenylnaringenin was isolated on silica thin layer chromatography, and the radical scavenging efficiency of the isolated compound was evaluated by DPPH radical assay. The results demonstrated that the isolated compound was found to be greater than that of BHT from lower (0.25 mM) to moderate (2 mM) concentrations and comparable to BHT at higher concentrations, up to 4 mM. The flavonoid was also found to exhibit good antifungal activity when tested against Candida albicans (ATCC 2091) and Aspergillus niger (ATCC...
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Posted by admin on Dec 31, 2020 in |
We have explored the nanoneedles from nanofabrication techniques, which could penetrate both nuclear and cellular membranes of cells. We received the individual nanoneedles with a tip diameter of 220-250 nm and the desired microscale length ~1 to 100 μm, which enable them for transdermal delivery of selective drug molecule by piercing stratum corneum, the outermost layer of skin. These nanoneedles possess Young’s modulus ~100 GPa, which is necessary for mechanical stability of nanoneedles during its penetration across stratum corneum for transdermal drug delivery. On the prefabricated structure of silicon, the arrays of nanoneedles were grown. The nanoneedles were further bio-functionalised using conjugation of drug molecule like Insulin with PEG and successfully delivered into the rat’s skin. The nanoneedles could be act as a vehicle for transport of Insulin drug molecules. The surface morphologies, basic structure and composition of the nanoneedles were confirmed using SEM, TEM, FTIR, ICPAES, XRD and TGA. Super-conducting quantum interference device (SQUID) magnetometer was used to ascertain the magnetic properties of nanoneedles. In-vivo studies after administration...
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