Posted by admin on Jun 30, 2025 in |
Prediabetes, a transitional metabolic state preceding type 2 diabetes, is characterized by insulin resistance, moderate hyperglycaemia, dyslipidaemia, and oxidative stress. This study evaluates the preventive effects of aqueous extracts from the leaves, calyces, and seeds of Hibiscus sabdariffa L. (white variety) on glucose and lipid metabolism disorders induced by a high-calorie diet in Wistar rats. Eight groups of six male Wistar rats were fed for 12 weeks with either a standard diet, a high-calorie diet, or a high-calorie diet combined with two doses (100 or 200 mg/kg) of the plant extracts. The leaf and calyx extracts significantly reduced weight gain, BMI, blood glucose, insulin levels, HOMA-IR, and HOMA-B indices (p < 0,05), showing no significant differences compared to the standard diet group (p > 0,05). Postprandial blood glucose levels also approached those of the standard group. These extracts significantly lowered triglycerides, total cholesterol, and atherogenic indices (TG/HDL-C, CRI, AIP) (p < 0.05), while the reduction in HDL cholesterol remained non-significant (p > 0,05). In contrast, untreated high-calorie diet rats...
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Posted by admin on Jun 30, 2025 in |
The study investigates to find the antioxidant and anti-inflammatory properties of the crude extract of coral Pseudopterogorgia australiensis. Various assays were used to assess the biological activities of the crude extract. The antioxidant capacity was evaluated using DPPH, ABTS, and FRAP tests. The DPPH assay indicated a dose-dependent radical scavenging effect whereas the ABTS assay showed a significant inhibition of which is comparable to ascorbic acid. In the case of FRAP assay it confirmed that the antioxidant activity revealing a strong reducing power which was equivalent to Trolox. These results demonstrated that the crude extract of Pseudopterogorgia australiensis have strong potential to neutralize ROS and mitigate oxidative damage. The Anti-inflammatory activity was assessed through albumin denaturation, proteinase inhibitory activity, and heat-induced heamolysis. The albumin denaturation assay demonstrated moderate inhibition where as the proteinase inhibitory assay showed stronger inhibition which is comparable to diclofenac sodium. In the case of heat-induced heamolysis it showed notable dose-dependent inhibition of protein denaturation which is comparable to the standard drug diclofenac sodium. From the...
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Posted by admin on Jun 30, 2025 in |
Introduction: Super Vasmol, an emulsion-based hair dye containing paraphenylenediamine (PPD), is an emerging cause of suicidal poisoning in developing countries, commonly presenting with cervicofacial oedema, rhabdomyolysis, and acute kidney injury (AKI). Cardiac involvement, though rare, typically manifests as tachycardia or myocarditis. This report highlights sinus bradycardia as an unusual presentation. Case Presentation: Two adult women with Super Vasmol poisoning developed marked sinus bradycardia during hospitalization. Case 1, a 34-year-old woman, presented with mild dysphagia and developed asymptomatic sinus bradycardia (heart rate [HR] 38–50/min) on day 3, resolving by day 6. Case 2, a 30-year-old woman, had mild cervicofacial edema and symptomatic bradycardia (HR 40–50/min) with giddiness and breathlessness on day 3, which normalized by day 6. Both patients recovered with conservative management. Conclusion: Sinus bradycardia is a rare but significant manifestation of Super Vasmol poisoning, potentially linked to PPD-induced cardiotoxicity or other components. Clinicians should recognize this atypical presentation to optimize management and reduce mortality in resource-limited settings where such poisoning is...
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Posted by admin on Jun 30, 2025 in |
Background: Seizure occurs more frequently in neonatal period than in any other time of life. Estimated incidence of neonatal seizure varies according to case definition, method of ascertainment and definition of the neonatal period and ranges from 1 to 5 per 1000 live births. Methodology: Neonates admitted in Nicu, department of Paediatrics, Nalanda Medical College and Hospital, Patna in time period of Aug 2023- July 2024. Sample size was 100. For seizure control in neonates with active convulsion either levetiracetam or phenobarbitone was allocated to the randomization. Intravenous levetiracetam is given at a loading dose of 20 mg/kg. Maintenance is given at a dose of 10mg/kg 8 hourly. Intravenous phenobarbitone is given at a dose of 20mg/kg and 5mg/kg 12hrly of maintenance dose. Results: In levetiracetam Group, 23(46.0%) patients had1number of loading dose required, 14(28.0%) patients had 2 number of loading dose required and 13(26.0%) patient had 3number of loading dose required. In phenobarbitone Group, 28(56.0%) patients had 1number of loading dose required, 9(18.0%) patients had 2 number of...
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Posted by admin on Jun 30, 2025 in |
Background: Allergic Fungal Rhinosinusitis (AFRS) is a common disease and denoted as Chronic Rhinosinusitis with polyps (CRSwNP). Presents as Eosinophilic nasal polyps, and allergic mucin in the nose and sinuses demonstrable with Functional Endoscopic sinus surgery (FESS) surgery. The biological markers predicting this disease entity are uncertain. Physicians experience difficult to predict the outcomes of various methods of treatment adopted to treat AFRS. Sometimes involvements of blood inflammatory cells were used to predict the recovery of the disease and its prognosis. Aim of the Study: To study the levels of pre-operative blood Eosinophils and Basophils in patients with AFRS and compare them postoperatively in terms of recurrence of polypi and allergic symptoms. Materials and Methods: 69 adult patients diagnosed with AFRS at the tertiary teaching Hospital in Andhra Pradesh were included. Patients were treated with FESS for AFRS. The final outcomes were assessed on the basis of blood Eosinophils and Basophils and correlating with the recurrence of symptoms and polypi. Results: Recurrence of polypi in 14 of 69 patients with overall...
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