Posted by admin on Sep 30, 2020 in |
Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demands. This leads to poor oxygen supply or cerebral hypoxia and thus leading to the death of brain tissues or cerebral infarction/ischemia stroke. It has been the third most common cause of death in developed countries; stroke can affect walking, talking, speech, vision, spatial awareness, swallowing, bladder control, bowel control, and balance co-ordination. The test drug Amaranthus spinosus leaves were defatted with petroleum ether (60-80 °C) and then extracted with hydroalcoholic solvent (Ethanol 95%, v/v: water, 1:1) by soxhlation process. The hydroalcoholic extract of the drug was evaluated for cerebroprotective activity in Wistar albino rats in the doses of 200 and 400 mg/kg by the Induction of cerebral ischemia/reperfusion followed by behavioural tests, infarct size measurement, and antioxidant activity. The test drug ASE produced the cerebroprotective activity in a dose-dependent...
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Posted by admin on Sep 30, 2020 in |
Medicinal plants are the predominant source of phytochemicals and nutraceuticals, and it is used for the treatment of many diseases for its high effectiveness, low cost, and wide availability. In the current research study five, commonly used ethnomedicinal weeds of West Bengal, and India namely; Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commmelina benghalensis, and Euphorbia hirta were used for analyzing their nutritional potentiality measurements. Different solvents extracts of leaves of the plants were used for detecting and quantifying the essential phytochemicals and nutraceuticals. For the quantitative study, UV-Vis spectrophotometer and titration method was used. Mineral content analysis was done by atomic absorption spectrophotometer followed by acid digestion method. To the best of our knowledge, the comparative evaluations of organoleptic, proximate characteristics, and nutritional components of these herbs are reported first. FT-IR study of leaves aqueous extracts reveals different types of functional groups. Among the studied plants, EH leaves extracts showed the highest amount of presence of polysaccharides, amino acids, ascorbic acids, thiamine, and riboflavin. CR leaves extracts showed the...
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Posted by admin on Sep 30, 2020 in |
Seeds of Hygrophila spinosa T. Ander (Acanthaceae) are traditionally used as an aphrodisiac and spermatogenic in the Indian System of Medicine. Studies were planned to evaluate the effect of unsaponifiable (sterol-enriched) fraction from chloroform extract, of the seeds of Hygrophila spinosa as spermatogenic and as aphrodisiac in-vivo, using rats as experimental animals. An unsaponifiable fraction was evaluated for its ability to stimulate testosterone production using isolated rat leydig cells in-vitro. The fraction was administered for 28 days to animals. At the end of the study period, biochemical evaluation of selected parameters, determining the increase in weight of reproductive organs, histological studies of testes, and sexual behavioral studies were performed as evaluation parameters. Increased serum cholesterol and testosterone level, increased weights of reproductive organs, and marked improvement in testes histo-architecture of rats suggested the spermatogenic potential of the fraction. Mounting behavior of test animals improved while the latency period was decreased, as observed in behavioral studies. Stimulation to leydig cells and increased serum testosterone level in-vivo might be responsible for...
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Posted by admin on Sep 30, 2020 in |
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and toxic side effects. The present study investigated the antiproliferative effects of Naraveliya zeylanica L. against the human lung cancer cell line A549. The cytotoxicity potential of ethanol extract of N. zeylanica was tested on A549 cell line by dose-dependent manner at concentrations ranging from 100-1000 µg/mL, and the viability of treated cells was evaluated by MTT assay. Different morphological changes in the cells and mode of cell death were analyzed by acridine orange/ethidium bromide (AO/EB) staining, single-cell gel electrophoresis (comet) assay and Hoechst staining methods. JC1 staining was adopted to check mitochondria-mediated apoptosis. Ethanol extract of N. zeylanica significantly inhibited the growth of lung cancer...
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Posted by admin on Sep 30, 2020 in |
This study is aimed at encapsulating Benzydamine Hydrochloride into nanosponges that involve different crosslinkers to polymers in the ratio of 1:1, 1:2, 2:3, etc., which are used, in order to protect these structures, to control their release and maintain their site-specificity. Emulsion Solvent Diffusion technique was applied for the formation of nanosponges, which were incorporated into carbopol hydrogel to give controlled release of the drug so that it adheres for a longer duration to the buccal mucosa and would gradually release the drug to give the desired release. The pre-formulatory DSC and FTIR study indicated there were no interactions of Benzydamine Hydrochloride (BZH) with excipients (Poly Vinyl Alcohol and Poloxamer 188). The formation of these nanosponges is confirmed through DSC, FTIR, FESEM, and TLC studies. BZH was loaded up to 88%, 85%, 72% w/w. Particle sizes of the loaded NS formulations were between 128 and 250 nm with low polydispersity indices of 0.6. Zeta potential was -17 to -150 mV, which gave a stable colloidal nanosuspension. Release studies were...
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