Posted by admin on Aug 31, 2020 in |
The present aim study is the formulation development and evaluation of extended-release matrix tablets of oxybutynin chloride by using hydrophilic and hydrophobic matrix systems. The pilot-scale batches of nine formulations were prepared using Eudragit RSPO, Eudragit RLPO, Carbopol 971NF, ethylcellulose individually, and in the combination of above polymer and Avicel PH102 by adopting direct compression method. The fabricated matrix tablets were assessed for their physicochemical properties and in-vitro drug release study. The drug-excipient interaction was evaluated by Fourier transform infrared spectroscopy, where no such interactions were observed. The F1-F3 formulation batches containing Eudragit RSPO in different proportions showed an effective drug release of nearly 99% at 24 h. The F4-F6 formulation batches contained Eudragit RLPO in the diverse amount presented an impressive drug release of >97%. In batches F7-F9, the combination of Eudragit RSPO and Eudragit RLPO produced a remarkable drug release of 100%. The optimized formulation F3 demonstrated a comparative similarity factor ƒ2 and less difference factor ƒ1 with that of the marketed tablet. The formulation F3 also...
Read More
Posted by admin on Aug 31, 2020 in |
Background: Tuberculosis (TB) is a global health burden and can cause potential infection in any system of the body. Pulmonary tuberculosis (PTB) is most common presentation, but the diagnosis of TB remains elusive because of none of biochemical or serological test is invalid. During the development of END TB strategy, the gene expert (CBNAAT) test was first endorsed by WHO. Materials and Methods: This was a prospective observational study; conducted in the Department of Microbiology, Baba Raghav Das Medical College, Gorakhpur Uttar Pradesh, India. All patients suspect of PTB fulfilling, inclusive criteria were enrolled for PTB confirmation. All kind of clinical samples pertaining to PTB were processed in TB laboratory for Ziehl-Neelsen stain microscopy, solid culture (Lowenstein-Jensen (L. J.) and gene expert. All data were collected and analyzed using SPSS ver. 2017. Results: During the study period, a total of 542 clinical PTB cases were enrolled. Among which distribution of clinical samples was (404/74.53% sputum, 104/19.18% gastric aspirate, 34/6.27% broncho-alveolar lavage: BAL). Among 542 total samples enrolled, 102 (18.81%)...
Read More
Posted by admin on Aug 31, 2020 in |
Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and anti-proliferative activity. The current work aimed to prepare and evaluate the nanoemulsions of CP loaded tea tree oil (TTO) would be stable nanoemulsion. Clinical use of CP is restricted to some extent due to its poor permeability across the skin. So, to increase its permeation across the skin, microemulsion based formulations were prepared and characterized. Microemulsions were prepared by aqueous phase titration method, using TTO, tween 20 transcutol P, and distilled water as the oil phase, surfactant, co-surfactant, and aqueous phase, respectively. Selected formulations were subjected to physical stability studies. Malven Zeta seizer did particle size distribution of nanoemulsion. In surface studies of the optimized formulation were done by Transmission Electron Microscopy. The nanoemulsion (A2) was a colloidal dispersion having average droplet size ranging from 100 to 200 nm. The nanoemulsion (A2) formulation exhibited a narrow size distribution (PI = 0.131). The optimized formulation exhibited viscosity 28.30 ± 1.91 mP, refractive index 1.403, pH 6.15, and conductivity 10-4 s cm-1. The optimized...
Read More
Posted by admin on Aug 31, 2020 in |
The aim of the present research work was to develop a bilayer floating dosage form of immediate-release Atorvastatin (ATR) and sustained release Captopril (CPT) in matrix form for the treatment of hyperlipidaemia and hypertension to reduce multiple dosing frequencies and enhance patient compliance. ATR belongs to the BCS Class II category having poor aqueous solubility, which was enhanced by using hydrophilic polymer PEG 8000 by kneading technique. A sustained layer of CPT was prepared by melt granulation technique using various concentrations of carnauba wax with HPMC K 100 M and Carbopol 934 P. All the parameters before and after compression were evaluated. ATR-PEG ratio of 1:0.25 showed a higher drug release of about 97.42% within 60 min. The optimized CPT sustained layer SR2 shown the highest drug release 98.2% in 12 h. In-vitro drug release studies carried out as per USP in pH 1.2 buffer using type II apparatus. The CPT layer exhibited release kinetics in the first order and followed the diffusion and erosion mechanism. The FTIR, XRD...
Read More
Posted by admin on Aug 31, 2020 in |
Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by various methods like UV-Vis spectroscopy, Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM). Silver nanoparticles having an average size of 31.92 ± 2.8 nm by TEM. The synthesized silver nanoparticles were discovered as an effective source of nanomedicine against MDR strains of Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of nanoparticles measured in the range from 11.4 ± 0.83 mm to 17.73 ± 0.91 mm. The highest zone of inhibition was reported against Pseudomonas aeruginosa i.e., 17.73 ± 0.91 mm at a concentration of 30 μg/μl. Silver nanoparticles showed increased total phenolic and total flavonoid content, additionally with higher DPPH activity as compared to the aqueous rhizome extract. Present...
Read More
