Posted by admin on Aug 31, 2020 in |
The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin syndrome induced by co-administration of fluoxetine and tranylcypromine. The body temperature of the animals was measured with thermistor probes (TX-8) inserted rectally and monitored on multichannel recorder. Pre-treatment with olanzapine inhibits hyper-thermic reaction in an experimental model of the serotonin syndrome and converts a hyperthermic response to serotonergic combination (fluoxetine and tranylcypromine) into a hypothermic response. Our results suggest prevention of the hyperthermia in a serotonin syndrome model with the use of olanzapine and support the hypothesis that the hyperthermic reaction in serotonin syndrome is mediated by activation of central 5-HT2...
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Posted by admin on Aug 31, 2020 in |
A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity against EGFR were performed by using the computer-assisted multiple regression procedure. The activity contributions for substituent effects of these compounds were determined from the correlation equation for predictions of the lead optimization. QSAR analysis of these compounds was performed by multiple regression analysis in order to predict the lead optimization for anticancer activity against...
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Posted by admin on Aug 31, 2020 in |
This case-control study had undertaken to evaluate effect of Allium sativum in normal rats. In this study ethanol extract of Allium sativum had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg b w p. o.) to male adult normal rats of charles foster strain for 15 days. Results of this study showing that alcoholic extracts caused no any significant reduction in blood glucose, total cholesterol, triglyceride, phos-pholipids, free fatty acid, lipid peroxide and no significant increased in post heparin lipolytic activity, but on the other hand as per pre-existing data and my published studies in diabetic patients and diabetic experimental animals showed that extracts exert all above effects significantly. That’s why it is very clear here if a healthy person will take natural products, it never causes hypoglycemia, hypolipidemia, and under the weight. Natural products also not cause any significant change in hepatospecific parameters. Thus, from this study, we conclude that natural products are safe, non-toxic, and free from side effects, in comparison to...
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Posted by admin on Aug 31, 2020 in |
Plumeria alba Linn. belonging to the family Apocynaceae (Dogbane family) is the flowering plant. P. alba is used as a purgative, rubefacient in rheumatism, asthma, piles, gonorrhea, blood disorders and tumors, mentioned in the traditional system of medicine. The present study was carried out to establish the pharmacognostic studies, physicochemical parameters along with a preliminary phytochemical screening of various extracts of P. alba leaves. The methanolic extract of the leaves of the plant was screened for anti-diarrheal potentiality. The macroscopical and microscopical characteristics of powdered drug were studied. The transverse section of leaf indicated the arrangement of various cells in epidermal, lamina, and midrib regions. The preliminary phytochemical screening of various extracts revealed the presence of phytoconstituents, including alkaloid, glycosides, phenolic and tannins, flavonoids, and sterols. The physicochemical parameters such as total ash and acid insoluble ash (9.5 and 7.3% w/w respectively), loss on drying (0.5% w/w), and extractive values water-soluble and alcohol-soluble (10.0 and 4.2% respectively) of powder drug were studied. These studies will be helpful to establish...
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Posted by admin on Aug 31, 2020 in |
Bastar is endowed with a unique blend of traditional knowledge and rich floral diversity. The region is known as the island of Shorea robusta, which is a key source for white and black truffle called Boda. It is also known as the black gold of the sal forest. It sets underground with the onset of early monsoon and is an edible mushroom with high protein, vitamin, and fiber with the low calorific value used by the local inhabitants as delicious food and in the amelioration of heart disease, blood pressure, and stomach disorder. Owing to its tremendous health benefits, the present study deals with the assessment of the protein content, isolation, and identification of fungi associated with boda. The qualitative analysis revealed that black boda contains more protein content than white boda. The quantitative estimation revealed the presence of 0.97 mg/ml and 0.33 mg/ml of protein for 0.2 mg weight of black and white boda, respectively. Further, the boda sample were inoculated on potato dextrose agar and incubated at...
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