Posted by admin on Aug 31, 2020 in |
The objective of the present study was to develop and validate a precise and accurate reversed-phase high-performance liquid chromate-graphy for simultaneous estimation of for Fluticasone Propionate (FUP) and Mupirocin (MUP) in combined topical dosage form as per ICH guidelines. Chromatographic separation was achieved using HPLC Shimadzu, Japan, with column syncronis C18 (250 × 4.6 mm, 5 μm). The mobile phase was comprised of 0.01% OPA: Acetonitrile (30:70v/v) (pH: 5) pumped at a rate of 1.0 mL/min. About 20 μL of sample solutions were injected and monitored at 232 nm. Column temperature and sample compartment were maintained at 25° and 5°, respectively. Repeatability, intra, and inter-day precision results were well within the tolerable limits. The linearity was found for range 2.5μg/mL – 7.5μg/mL and 100μg/mL – 300 μg/mL for FUP and MUP respectively. The correlation coefficient of linearity was found to be 0.998 and 0.994 for FUP and MUP, respectively. The limit of detection was found to be 0.3527, and 0.5077and limit of quantification was found to be 1.0690 and...
Read More
Posted by admin on Aug 31, 2020 in |
Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. Atenolol, an antihypertensive drug with a short half-life, limited bioavailability, unstable nature at basic pH potentiated the need for developing a gastro-retentive system, hence super porous hydrogel of Atenolol had been developed with cellulosic polymers, and adequate strength was imparted by the addition of Ac- Di- Sol. The structural morphology of hydrogel was investigated by SEM, and it was found that plenty of pores of different size ranges, like 1 µm, 2 µm, 10 µm were formed. Compatibility studies proved the integrity of the super porous hydrogel. Gelation time was found to vary with respect to the formulation. The setting time of super porous hydrogel was found to be increased with an increase in the concentration of HPMC K100M. The drug release from super porous hydrogels was sustained for 10 h. In-vitro...
Read More
Posted by admin on Aug 31, 2020 in |
The nasal drug delivery system has been a promising route for delivery of proteins and peptides as it can avoid degradation in the gastrointestinal tract and metabolism by liver enzymes. However, due to the rapid mucociliary clearance, the bioavailability of proteins and peptides is still low. Hence, mucoadhesive microspheres may prolong the residence time of peptide drugs in nasal cavity and improve their absorption. In the present study chitosan microspheres loaded with a model peptide vancomycin hydrochloride were prepared. Drug-excipient compatibility studies were done to investigate and predict any possible interactions between the components in the formulation. The prime objective of the study was to check the influence of different process variables and formulation parameters on the two key parameters viz particle size and percentage entrapment efficiency of vancomycin loaded chitosan microspheres and to develop a formulation with desirable particle size for nasal delivery and with maximum possible entrapment efficiency. Drug-excipient compatibility study indicates that vancomycin hydrochloride is compatible with the polymer chitosan. Drug loaded chitosan microspheres were successfully...
Read More
Posted by admin on Aug 31, 2020 in |
The present research was envisaged on the development of dry powder to treat asthma. Terbutaline sulphate (a bronchodilator) and Itraconazole (an antifungal) were used in the present study for bronchodilation and allergy to Aspergillus fumigatus (fungi) using lactose and trehalose as excipients. Dry powder insufflations were prepared by physical mixing (milling) and spray drying, out of which spray dried formulations with lactose as excipient gave the best results in-vitro. Hence, spray dried formulations were preceded for further pharmacokinetic and stability studies. The pulmonary concentrations of Terbutaline sulphate and Itraconazole from TER – A (sd), ITR – A (sd), TER: ITR – A (sd) monotonically decreased (Tmax = 0 min). However, Itraconazole showed higher AUC0-α in individual and combined formulation when compared to Terbutaline sulphate showing slower elimination of Itraconazole. From plasma pharmacokinetic data Tmax of Itraconazole formulations ITR – A (sd), TER: ITR – A (sd) was high when compared to the formulations of Terbutaline sulphate TER – A (sd), TER: ITR – A (sd) showing lower systemic bioavailability...
Read More
Posted by admin on Aug 31, 2020 in |
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Management of behavioral risk factors is recommended for primary and secondary prevention of CVDs. There is evidence that the involvement of community pharmacies in health promotion activities is successful. Objectives: This study was conducted to assess community pharmacists’ perception and current practice in providing lifestyle assistance to patients with cardiovascular disease and to identify potential barriers to the provision of lifestyle assistance in Klang Valley, Malaysia. Method: A cross-sectional study was conducted among community pharmacists in Klang Valley using convenience sampling. A self-administered 54-item questionnaire was used to collect information on the current practice and perception of community pharmacists, and potential barriers in providing lifestyle assistance to patients with cardiovascular disease. Results: The response rate was 62.8%. Most of the services investigated were available in the pharmacy except for advice on alcohol consumption (52.7%) and screening and/or monitoring services for obesity (57.7%), which are less likely to be available. For most of the listed activities in relation to...
Read More
