Posted by admin on Aug 31, 2020 in |
Rumex obtusifolius, belonging to the Polygonaceae family, commonly known as ‘broad-leaf-dock’ is one of the most important medicinal plants. It is common wayside weeds and uses as an antidote to nettle, depurative, astringent, laxative, and tonic and in the treatment of sores, blisters, jaundice, burns, cancer, and tumors. In this study, we design to synthesize silver nanoparticles from silver nitrate via a green route using the aqueous leaf extracts of Rumex obtusifolius. This biogenic reduction of metal ion to base metal is quite rapid, readily conducted at room temperature and pressure, and easily scaled up. The use of silver nanoparticles is gaining popularity due to its antibacterial properties. The silver nanoparticles formation in the solution was monitored by UV-Vis spectroscopy, and further characterization was carried out by FT-IR (Fourier Transform Infrared Spectroscopy), XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy) analysis. To optimize the biosynthesis of silver nanoparticles, the effect of process variables such as extract concentrations, the mixing ratio of the reactants, time, and...
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Posted by admin on Aug 31, 2020 in |
The aim is to prepare sustained release multi-particulates dosage form of Dexketoprofen trometamol, which is the active isomer of ketoprofen. Utilization of active moiety with minimum drug dose and administration frequency sustained-release multi-particulates dosage form is explored. Sustained release pellets of the dexketoprofen trometamol were developed by the fluidized bed technology, in which drugs along with a binder and anti-adherent agents, were loaded onto microcrystalline cellulose inert beads. These drug-loaded pellets were again coated with Kollicoat SR 30D as sustained-release coating polymer, triethyl citrate as plasticizer and talc as an anti-adherent. The formulation was further statistically optimized for agglomerates formation, process efficiency, and drug release profile using central composite design (CCD). Results show that 16.9 to 18.5% w/w sustained release coating with 9.0-14.6% w/w talc and 8.1 to 16.5% w/w triethyl citrate concentration gives desired drug product quality attributes. Sustained-release multi-particulates were successfully developed for dexketoprofen trometamol, which maybe explored to manufacture various dosage forms like capsules, compressed tablets, pellets in sachet etc. for ease of patient...
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Posted by admin on Aug 31, 2020 in |
Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carried out on C18 Thermo Hypersil BDS (250 × 4.6 × 5 mm) column, using ammonium acetate: acetonitrile (70:30) pH 6.8 as mobile phase with flow rate 1ml/min and analysis was done using PDA detector at an ambient temperature where 3.15 min was retention time of the drug. The Linearity, precision, and accuracy were found to be satisfactory over the concentration range of 10 to 60 µg/ml of the drug. The correlation coefficient was 0.987. Drospirenone was found to degrade in 1% H2O2 to the extent of 19% after 1 h. More degradation was observed by using 3% H2O2 at 80 ºC. Interestingly, in the applied conditions, the new compound...
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Posted by admin on Aug 31, 2020 in |
The outburst of new coronavirus (COVID-19) infections, firstly appeared in Wuhan in 2019, has massively expanded to the whole world. At the end of March 2020, the rapid spread of the infection happened in about 206 countries around the globe. At the moment, the statistics of WHO on coronavirus pandemic revealed total infected cases of 21,770,000 and more than 77,000 deaths all over the world, with no proven antiviral agent available yet to control COVID-19 infection. The world is currently in desperate need of finding potent therapeutic agents. Histone deacetylases (HDACs) represent one of the most promising viral targets. Importantly, HDACs are critical factors involved in the control of viral replication. The molecular mechanisms associated with underlying the role of HDACs in viral latency, viral reactivation, and carcinogenesis are progressively disclosed. Till now, six HDACIs anticancer drugs have been approved by the FDA. Herein, in the in-silico structure-based drug design approach was utilized to identify novel structural characteristics for the potential repurposed activity of HDACIs as antivirals for COVID-19....
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Posted by admin on Aug 31, 2020 in |
Centella asiatica (CA; family Apiaceae) is extensively used in traditional medicine. A regular supply of this plant is required by the herbal drug industry. Hence, the cultivation of this plant is required. The emphasis of the available cultivation practices is on biomass yield. The activity of the plant, however, depends on the amount of bioactive constituents. The production of these secondary metabolites is influenced by biotic as well as abiotic factors. This study was carried out to determine the abiotic factors that enhance the production of secondary metabolites in CA. CA plants were grown in two seasons (i.e., season 1: August to December and season 2: February to June) on different soil types (Clay loamy, Red, Black), and various stresses were applied to the plants. At the end of each season, plant yield, extract yield, asiatic acid content, antioxidant, and acetylcholinesterase inhibition activities were determined. Asiatic acid content was determined by an HPLC method. The results show the varied response of CA plants to seasons, soil, and stresses. CA...
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