Posted by admin on Jan 31, 2025 in |
Head and Neck Squamous Cell Carcinoma (HNSC) is a fast-growing form of cancer. This cancer originates in the squamous cells of the mouth and throat and primarily affects individuals who engage in risky lifestyle choices such as tobacco and alcohol consumption. The poor prognosis and high mortality rate of HNSC underline the urgent need for extensive research and novel treatment approaches. This comprehensive study aims to determine the genetic and gene expression differences between male and female patients with Oral Squamous Cell Carcinoma (OSCC). It will also be examined whether differences in unique genes are common in both male and female patients. We used the Galaxy web server to conduct a study employing whole exome sequencing (WES) and RNA sequencing (RNA-Seq) data. The research we conduct requires accurate sample preparation that allows us to obtain useful insights. We found variations in the aligned reads within the WES data that provide insight into particular genetic variations associated with OSCC. At the same time, we discovered various gene expression patterns in...
Read More
Posted by admin on Jan 31, 2025 in |
Aim: This study aimed to compare the analgesic efficacy of caudal ropivacaine and ketamine with ropivacaine and midazolam in paediatric patients undergoing infraumbilical surgery. Material and Methods: A study was conducted involving a group of 100 paediatric patients who underwent infraumbilical surgery. The study participants were divided into two groups: Group A received 1.0 ml/kg of 0.15% ropivacaine with 0.3 mg/kg of ketamine, while Group B received 1.0 ml/kg of 0.15% ropivacaine with 0.03 mg/kg of midazolam. The duration of the surgery, the duration of anaesthesia, the use of inhalation agents, and any complications were carefully documented. Results: The TTFAR for groups A and B were 14.5±3.50 hours and 12.26±4.12 hours, respectively. There was a significant difference in values between groups A and B (p≤0.05). The mean total fentanyl acetaminophen consumption in 24 hours was 101.79±79.14 mg for group A and 117.50±97.50 mg for group B. After the surgery, there was a noticeable difference in the FLACC pain scores between the two groups at various time intervals. Conclusion: The...
Read More
Posted by admin on Jan 31, 2025 in |
Background: Drug-induced gingival overgrowth (DIGO) is a common side effect of certain medications used for non-dental purposes, notably anticonvulsants, calcium channel blockers (CCBs), and immunosuppressants. These drugs, despite differing pharmacologically, inhibit intracellular calcium ion influx, leading to a decrease in collagenolytic activity and an increase in fibroblasts and collagen synthesis, ultimately causing gingival overgrowth. Case Presentation: A 54-year-old male presented with significant gingival enlargement and periodontal disease. Clinical examination revealed generalized mild to moderate calculus, erythematous and indurated gingiva with severe periodontal attachment loss, and tooth mobility. Despite scaling and root planning, the gingival enlargement persisted, necessitating surgical intervention. Open flap debridement was performed, leading to a successful outcome with no recurrence of gingival enlargement after one year of follow-up. Discussion: The case highlights amlodipine-induced gingival overgrowth, a recognized side effect of CCBs. The exact mechanisms remain unclear, with both inflammatory and non-inflammatory pathways implicated. The inflammatory process involves cytokine upregulation, leading to fibroblast proliferation and fibrotic gingival hyperplasia. The case underscores the importance of early diagnosis, medication management,...
Read More
Posted by admin on Jan 31, 2025 in |
Background: There are numerous anti-seizure drugs on the market, but side effects at the highest dosage that can be tolerated account for the majority of prescription discontinuations. Research on Musa paradisiaca’s synergistic activity is of utmost importance in getting insight into its anti-seizure potential. Methods: Anti-seizure activity of Musa paradisiaca on generalized tonic-clonic seizure was evaluated using standard maximal electroshock seizure method and on absence seizure using pentylenetetrazole test. Both models had 6 groups each: vehicle control, active control, high dose herb, low dose herb, combination of active control (sub-therapeutic dose) with low dose herb & combination of active control (sub-therapeutic dose) with high dose herb. Results: In MES model Musa paradisiaca in high dose prevented both tonic extension and tonic flexion. In PTZ model Musa paradisiaca in high dose and low dose significantly increase the latency of onset of seizures and decrease the duration of seizure compared to vehicle control. There was no significant effect on onset of 1st myoclonic jerk. Addition of Musa paradisiaca to the sub-therapeutic...
Read More
Posted by admin on Jan 31, 2025 in |
Metabolic syndrome is continuously on the rise, due to a changed lifestyle and long ageing. The abnormal function of mTOR/AMPK, a cellular energy switch, is the main cause behind this pathogenesis, which is now defined as “metabolic syndrome”. Here, we have screened the metabolites of shilajit, obtained from the HRAMS analysis, to select the direct activators of AMPK, by using computational exploration, through molecular docking and ADMET prediction. The shilajit has been in clinical use in Ayurvedic medicine, for centuries, to enhance the overall vitality, immunocompetence and aphrodisiac potential, but scientific data are lacking to support its therapeutic claims. The shilajit, of Upakarma Ayurveda was purchased from the market and analyzed through HRAMS, which reported the presence of 5467 metabolites. Their CID numbers were obtained from the PubChem portaland docked against the AMPK (AMPK active site PDB ID-4CFF), by using LibDock and Discovery Studio to do a structure-based screening, ADME (absorption, distribution, metabolism, excretion) and toxicity prediction. Among them, Reproterol (CID-25654) and Ambruticin (CID-6918547) showed the best binding energy,...
Read More
