Posted by admin on Aug 31, 2020 in |
This case-control study had undertaken to evaluate effect of Allium sativum in normal rats. In this study ethanol extract of Allium sativum had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg b w p. o.) to male adult normal rats of charles foster strain for 15 days. Results of this study showing that alcoholic extracts caused no any significant reduction in blood glucose, total cholesterol, triglyceride, phos-pholipids, free fatty acid, lipid peroxide and no significant increased in post heparin lipolytic activity, but on the other hand as per pre-existing data and my published studies in diabetic patients and diabetic experimental animals showed that extracts exert all above effects significantly. That’s why it is very clear here if a healthy person will take natural products, it never causes hypoglycemia, hypolipidemia, and under the weight. Natural products also not cause any significant change in hepatospecific parameters. Thus, from this study, we conclude that natural products are safe, non-toxic, and free from side effects, in comparison to...
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Posted by admin on Aug 31, 2020 in |
Plumeria alba Linn. belonging to the family Apocynaceae (Dogbane family) is the flowering plant. P. alba is used as a purgative, rubefacient in rheumatism, asthma, piles, gonorrhea, blood disorders and tumors, mentioned in the traditional system of medicine. The present study was carried out to establish the pharmacognostic studies, physicochemical parameters along with a preliminary phytochemical screening of various extracts of P. alba leaves. The methanolic extract of the leaves of the plant was screened for anti-diarrheal potentiality. The macroscopical and microscopical characteristics of powdered drug were studied. The transverse section of leaf indicated the arrangement of various cells in epidermal, lamina, and midrib regions. The preliminary phytochemical screening of various extracts revealed the presence of phytoconstituents, including alkaloid, glycosides, phenolic and tannins, flavonoids, and sterols. The physicochemical parameters such as total ash and acid insoluble ash (9.5 and 7.3% w/w respectively), loss on drying (0.5% w/w), and extractive values water-soluble and alcohol-soluble (10.0 and 4.2% respectively) of powder drug were studied. These studies will be helpful to establish...
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Posted by admin on Aug 31, 2020 in |
Bastar is endowed with a unique blend of traditional knowledge and rich floral diversity. The region is known as the island of Shorea robusta, which is a key source for white and black truffle called Boda. It is also known as the black gold of the sal forest. It sets underground with the onset of early monsoon and is an edible mushroom with high protein, vitamin, and fiber with the low calorific value used by the local inhabitants as delicious food and in the amelioration of heart disease, blood pressure, and stomach disorder. Owing to its tremendous health benefits, the present study deals with the assessment of the protein content, isolation, and identification of fungi associated with boda. The qualitative analysis revealed that black boda contains more protein content than white boda. The quantitative estimation revealed the presence of 0.97 mg/ml and 0.33 mg/ml of protein for 0.2 mg weight of black and white boda, respectively. Further, the boda sample were inoculated on potato dextrose agar and incubated at...
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Posted by admin on Aug 31, 2020 in |
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmaco-logical activity of crude methanol extract of Calamus rotang L. (CRME) leaves. The analgesic activity and thrombolytic activity were examined by the acetic acid-induced writhing method, while the clot lysis effect was evaluated by an in-vitro thrombolytic method. From this study, it is stated that the extract (400, 200 mg/kg) reduced abdominal writhing by 31.06% and 44.33% for 200 mg/kg and 400 mg/kg respectively while the standard showed 58.57% of inhibition and increased the pain reaction time in mice when compared to that of the negative control group in tail-immersion test. The extract presented 16.2 ± 1.75% of human blood clot lysis in the thrombolytic experiment. The presence of steroids, saponins, glycosides, cardenolides, flavonoids, carbohydrates, and reducing sugars might have an influence on the pharmacological activity of...
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Posted by admin on Aug 31, 2020 in |
The new asymmetrical tetradentate (ONNO) Schiff base (L) 4-chloro- 2- ((E)- (4- ((E)-((2-hydroxy-5-nitrophenyl)imino)methyl)benzylidene) amino)phenol was prepared by the condensation of terephthalaldehyde with 2-amino 4-chlorophenol and 2-amino 4-nitrophenol in 1:1:1 molar ratio in methanol. The homo binuclear metal(II) complexes were synthesized in ligand to metal ratio 2:2 from the template method. The composition, geometry and binding sites of ligand and its complexes were determined by various studies like Elemental, molar conductance, electronic, magnetic moment, FT-IR, 1H and 13C-NMR, ESI-Mass, EPR, Thermal, and PXRD. The above spectral studies show that the Schiff is a dibasic tetradentate (ONNO), and its metal complexes possess a square planar structure. The biological applications of all compounds were tested for antibacterial, antioxidant, and DNA cleavage, and the final reports reveal high inhibition activity for metal(II) complexes compared to the ligand. The DNA binding activities of Cu(II) complex was observed by electronic absorption method. Antitumor activity of Cu(II) complex was screened for their cancer-inhibiting ability against MCF-7 human breast cancer cells by using the MTT...
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