Posted by admin on May 31, 2020 in |
Objective: In the present study to enhance solubility and in vitro dissolution of poorly aqueous soluble drug Famotidine by preparing solid dispersions using the Kneading method. Methods: Solid dispersions of the drug were prepared by the kneading method using Kollidon and Povidone K30 (as a carrier). Eight different drugs: Carrier ratios were prepared by Factorial design taking three factors, i.e., the concentration of Famotidine (X1), Kollidon (X2), and Povidone K30(X3). Results: DSC, FTIR spectroscopy, powder X-ray diffraction (XRD), and SEM studies were used to characterize solid dispersions. In vitro release was carried out using the USP II dissolution apparatus. Multilinear regression analysis was applied to develop a mathematical model to estimate cumulative drug release. The batch F4 was found to be best batch as it showed maximum solubility and in-vitro dissolution after 30 min. Improvement in the dissolution behavior of solid dispersion batches was observed due to the conversion of a crystalline form of drug to amorphous form as confirmed by DSC, FTIR studies, and X-RD studies. SEM photographs...
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Posted by admin on May 31, 2020 in |
An attempt was made to formulate and evaluate Fexofenadine HCl loaded chitosan nanoparticles using biodegradable polymers such as chitosan and sodium tripolyphosphate as a crosslinker in different ratio and proportions. In this formulation, Fexofenadine HCl was selected because of wide range of its use in treatment of skin allergy in the form of coated tablet and pediatric suspension. Different formulations of Fexofenadine HCl loaded chitosan nanoparticles were prepared containing 0.5%, 0.75% of chitosan and 0.5% STPP as crosslinker using ionic gelation technique. Nanoparticles were characterized for particle size determination, Polydispersity index, Zeta potential, % Entrapment Efficiency and in-vitro release study and Scanning Electron Microscopy. For the formulations F6-F10, no yield was formed which might be due to an insufficient amount of crosslinker to form the nanoparticles. F2 was selected as the best formulation to be incorporated into the gel base using carbopol 934P in different concentrations of 0.5%, 0.75%, and 1%. The formulated gels were evaluated in case of viscosity, spread ability, in-vitro release study, kinetic and skin irritation...
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Posted by admin on May 31, 2020 in |
Diet and dietary habits of an individual are considered to be an essential factor based on biologically active compounds extracted or modified from either known or unknown natural sources, contributing to completing the dietary and nutritional needs beyond the traditional supplements. Moreover, the latest research information about their supportive and therapeutic utility suggests that they play a potential role in promoting the overall sensory and motor synergies in the brain, reducing cognitive decline and activating neuronal receptors. Many of the functional food items are reported to have many effective bioactive compounds such as – polyphenols, flavonoids, stilbenes, terpenoids, carotenoids, alkaloids, omega 3, PUFA, etc. Also, various phyto-compounds (ginseng, vitamin B12, alpha-lipoic acid, berry anthocyanins, trans-resveratrol, Ginkgo biloba, Bacopa monniera, Huperzine A, Centenella asiatica, vinpocetine, tocotrienols and palm oil, selenium) are noted globally for incrementing the cerebral health and its upkeep, listed as functional foods. This review study focuses on the direct co-relation and various effects of functional foods in reducing or preventing the neurodegeneration process. Authors have also summarized...
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Posted by admin on May 31, 2020 in |
Multiparticulates consist of discrete, small, multiple unit systems of active pharmaceutical ingredients exhibiting the desired drug release pattern. The present work is concerned with the formulation and evaluation of a pH-dependent multiparticulate colon targeted drug delivery system of ketoprofen, a well established anti-inflammatory drug used in the management of inflammatory bowel disease. The reason for carrying out this study was to release the drug at a targeted site of the large intestinal region of the gastrointestinal tract on the basis of pH variability and to improve patient compliance. The drug-loaded pellets were fabricated using powder layering technology and thereafter pH-dependent multiparticulates were prepared by employing a mix polymeric coating of pH-dependent Eudragit S100 and Eudragit L100 polymers over the drug-loaded pellets. Different ratios of these pH-dependent polymers were used in the formulations of the coated drug-loaded pellets. The developed pellets were assessed for technical parameters such as drug entrapment efficiency, in-vitro dissolution study, scanning electron microscopy, FTIR, and DSC study. The in-vitro release kinetics reveals that the optimum formulation...
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Posted by admin on May 31, 2020 in |
A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm using a PDA detector. The retention time was 2.93 ± 0.1 min, and the method produced a linear response in the concentration range of 4.5-27 µg/ml (r2– 0.9995). In recovery studies, %RSD from reproducibility was found to be below 2%. LOD and LOQ were 0.1 µg/ml and 0.34 µg/ml, respectively. The drug was subjected to different stress conditions such as acidic, alkaline, oxidative, photothermal, and hydrolysis. The drug showed more degradation in acidic conditions, and no degradation was observed in hydrolysis and photo conditions. The developed RP-HPLC method was found to be effective, sensitive, and specific for the estimation of Inotuzumab Ozogamicin in bulk...
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