Posted by admin on Jan 31, 2025 in |
Background: In dry and semi-arid regions of the world, Prosopis juliflora is one of the most significant tree species both commercially and environmentally. Leguminosae (Fabaceae) is the family to which Prosopis juliflora belongs. Aims and Objectives: To evaluate the analgesic activity of methanolic extract of dried leaves of Prosopis juliflora Linn. Materials and Methods: In this investigation, adult male Wistar rats weighing between 100 and 150 grams were utilized. Prosopis juliflora Linn. methanolic extract was given orally to healthy albino rats at dosages of 300 and 500 mg/kg body weight in order to assess the acute analgesic efficacy using the tail flick technique. Result: The methanolic extract demonstrated a substantial and dose-dependent reduction in the reaction time on tail-flick throughout the course of the 60 minutes in acute trials. Turkey’s test was performed after one-way ANOVA was used for statistical analysis. Conclusion: Methanolic extract of Prosopis juliflora Linn. possesses analgesic activity in a dose-dependent manner in thermal induced...
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Posted by admin on Dec 31, 2024 in |
Background: Cuvācakācam (SwasaKaasam) is one of the twelve types of Kācam in Siddha System of Medicine and is clinically correlated with Bronchial Asthma. Asthma is a Non-Communicable Disease that affects global health invariably by affecting all age groups with 5th global rank in terms of Daly’s. According to GBD, 13.09% of the population in India suffered from asthma and the prevalence in Puducherry was 8.6%. The present conventional anti-asthmatic drugs have several side effects, and the patient’s QoL is also compromised. Thus, it is imperative to explore alternative or complementary therapeutic techniques in view of adverse effects, out-of-pocket expenses, and patient compliance. Aim: The present study aims to evaluate the safety and effectiveness of Swasa Kudori Chooranam in Bronchial Asthma patients. Methods: This is a single-arm pilot study of 37 participants with a known history of Cuvācakācam (Bronchial asthma). Trial drug will be advocated for a period of 30 days as per the prescribed dose followed by baseline investigations. The outcome assessments included PFT, ACT, mMRC Dyspnoea Scale, AQLQ(S);...
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Posted by admin on Dec 31, 2024 in |
A series of benzimidazole-linked triazoles hybrids (4a-4u) have been synthesized by simple cyclization, followed by amide coupling and click reaction starting from o-phenylene diamines as substrates with 4-formylbenzioc acid, propargylamine and followed by treatment with aryl azides. The structure of synthesized compounds (4a-4u) was confirmed by spectral techniques. The prepared compounds were screened by the agar well diffusion method against both Gram-positive bacteria (S. aureus, B. subtilis, M. luteus and B. megatherium) as well as Gram-negative bacteria (E. coli, K. pneumoniae, S. typhi and S. paratyphi). Analysis of antibacterial activity profile of synthesized compounds revealed that compounds (4a) and (4c) exhibited prominent activity against all tested Gram positive and Gram-negative...
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Posted by admin on Dec 31, 2024 in |
Introduction: Simvastatin is one of the cholesterol-reducing agents, in the class of statins which is an HMG-CoA reductase inhibitors, used in the treatment of hyperlipidemia. It was categorized in biopharmaceutics classification system (BCS) class II drug, which has low solubility in aqueous media. It is a white-to-off white crystalline and non-hygroscopic powder, insoluble in water, but soluble in methanol, chloroform, and ethanol. Characterization test as FTIR spectroscopy was important to identify the identity of tablets. Tablets properties were evaluated by various physicochemical parameters including dissolution test to examine the equivalence and quality of different marketed brands of Simvastatin. They should comply with the specified pharmacopoeia limit for each test. Objectives: Objective of this study was to analyze the identity and evaluate the quality control parameters of different brands of Simvastatin with the specified pharmacopoeia limit. Method: Different brands of Simvastatin 20 mg tablets were collected by purchasing from local pharmacies in Malaysia. Physicochemical parameters such as weight variation, thickness and diameter measurement were performed. Besides, characterization test using FTIR...
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Posted by admin on Dec 31, 2024 in |
Aim & Background: Silicosis is a prevalent occupational lung disease caused by inhalation of Respirable Crystalline Silica (RCS), leading to irreversible pulmonary fibrosis and restrictive lung disease. This study investigates the therapeutic potential of a combination of methanolic extracts from Glycyrrhiza glabra (licorice) root and Citrus limon (lemon) leaf (CMEGC) against silica-induced silicosis in Wistar rats, leveraging their known antioxidant and anti-inflammatory properties. Methods: The experimental protocol involved dividing rats into six groups, including a control group, a silicosis model group, a Pirfenidone-treated group, and groups treated with the combined extracts at two different dosages (200 mg/kg and 400 mg/kg). Silicosis was induced through aerosol inhalation of SiO2. Various parameters, including body weight, hematological markers, pulmonary edema, TNF-α levels, oxidative stress markers, and lung collagen content, were assessed to evaluate the efficacy of the treatments. Results & Conclusion: Results indicated that the combined extracts significantly improved body weight and reduced pulmonary edema, TNF-α levels and oxidative stress markers compared to the silicosis model group. Histopathological analysis confirmed reduced lung...
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