Posted by admin on Apr 30, 2020 in |
Sialic acid is the active site of neuraminidase virus and it proliferates the infection in the human body by cleaving it from the neuraminidase viral protein. The buried water molecule influences the binding between the ligand and the receptor. Hence, solvation dynamics and hydration pattern of sialic acid needs to be investigated to design the antiviral inhibitor. Cluster continuum solvation analysis reveals that the hydrated structures of sialyate ion are progressive increases as a function of water molecules by explicit solvation method, and this pattern attests the presence of buried water molecules in the hexa hydrated structure. Thus, it confirms the presence of trapped water molecules near the functional site of sialic acid. Hence, it can be considered as a promising candidate for the design of a sialidase antiviral...
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Posted by admin on Apr 30, 2020 in |
Polyherbal formulations are a collection of therapeutic entities that are formulated and prepared on the basis of the healing properties of individual ingredients with respect to the condition of sickness. The main objectives of the present study were to evaluate the pharmacognostic parameters of a traditional polyherbal formulation for the treatment of hemorrhoids (piles). The pharmacognostic parameters i.e., microscopic, physicochemical, phytochemical, antioxidant, anti-bacterial assay and FTIR analysis, was evaluated. The microscopic study of plant materials gives details about anatomical identity. The phytochemical evaluation of crude extract (methanolic and aqueous) of gutika revealed the presence of bioactive compound. In DPPH and H2O2 scavenging assay of methanolic extract (IC50 200 µg/ml) has better antioxidant activity than aqueous extract (IC50 250 µg/ml). The study also revealed that the methanolic extract showed the highest total phenolic and flavonoid content followed by aqueous extract. The FTIR spectra of both methanolic and aqueous extracts revealed the presence of polyphenols, terpenes and alkaloids. The antibacterial activity of methanolic extract shows highest zone of inhibition than aqueous...
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Posted by admin on Apr 30, 2020 in |
Ethanolic extract of the whole plant of Mollugo oppositifolia L. of Molluginaceae has been analyzed by using GC-MS for Bioactive compounds and for their pharmacological activities. GC-MS showed 32 compounds and is confirmed with the help of the database of NIST. Out of these, seven major Bioactive compounds are identified based on their retention time and peak area in GC-MS chromatogram. Among these seven bioactive compounds, Estran-3-one is highest with 33.5%, and dodecanoic acid is lowest with 5.75%. hexadecanoic acid, stigmasterol, estran-3-one, and 8, 11, 14-eicosatrienoic acid are having a higher number of pharmacological...
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Posted by admin on Apr 30, 2020 in |
The aim of this study was to formulate and evaluate nine formulations of Gefitinib loaded PLGA nanoparticles by homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different concentration of 120 mg, 150 mg, and 200 mg. Preformulation studies of FTIR and DSC was done to determine possible interaction between the drug and excipients. A5 showed 75.14% of release after 72 h and followed the fickian diffusion pattern of kinetic. SEM image showed the spherical morphology of...
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Posted by admin on Apr 30, 2020 in |
Allmania nodiflora (L.) R. Br. is a diffuse herb, belongs to family Amaranthaceae. Fresh leaves used as a green leafy vegetable, which is rich in vitamins and iron. The present aim of this work is to evaluate the phytochemical composition and antioxidant activity of ethanol and water extracts of A. nodiflora leaves. The results on the phytochemical composition of the water and ethanol extracts of A. nodiflora revealed that water extract showed a higher amount of total phenolic (TPC) and total flavonoid (TFC) contents than ethanol extract. Regarding antioxidant activity results, both water and ethanol extracts showed a higher amount of total antioxidant capacity (TAC) and dose-dependent activity against the DPPH, hydroxyl radical and lipid peroxidation activity. In conclusion, the water extract of A. nodiflora leaves showed a high amount of TPC, TFC and TAC and strongly inhibited DPPH, hydroxyl radical and ferric chloride-induced lipid peroxidation in goat liver tissue homogenate. The findings of the study suggest that A. nodiflora leaves could be used as a potential source of...
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