Posted by admin on Apr 30, 2020 in |
Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Oxcarbazepine spherical agglomerates were prepared by crystallo-co agglomeration technique. Acetone acted as a good solvent, aqueous solution of PEG 6000 served as a bad solvent, and dichloromethane was used as bridging liquid. The optimization was carried out using 23 factorial design, where the factors were rotation speed, polymer-drug ratio and amount of bridging liquid. The responses evaluated were % drug release, mean yield pressure (MYP), and carr’s index. The optimized agglomerates and oxcarbazepine were evaluated by powder x-ray diffractometer (PXRD) and scanning electron microscopy (SEM). The agglomeration improved the micromeritic properties of oxcarbazepine. PXRD showed reduction in crystalline nature of oxcarbazepine, and SEM demonstrated a spherical and smooth surface. In-vitro dissolution increased by 10-fold. The AUC (35.19%), Cmax (23%), and tmax (reduced by 1h) also recorded improvement. From the results, spherical agglomerates are a suitable method and can be used to design immediate-release...
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Posted by admin on Apr 30, 2020 in |
Aims and Objectives: To evaluate and compare diclofenac and meloxicam as tablets and as mucoadhesive patches in the control of odontogenic pain. Materials and Methods: 60 patients of either sex with acute dental pain were included in the study. Informed consent was obtained from each patient and they were randomly divided into 4 groups. Group A1 received meloxicam tablets, A2 meloxicam mucoadhesive patches, B1 diclofenac tablets, and group B2 was allotted diclofenac mucoadhesive patches. A 10 cm Visual Analogue Scale (VAS) was used to record pain scores at baseline, 20 and 30 min post-administration. Patients were also given the allotted tablets and patches to be used for 2 days, along with a pain diary to record their VAS scores at 30 min post-administration. Diary was collected and data analyzed on the 4th day. Results: Statistically significant reduction in pain was seen in all 4 groups from baseline to the end of the study period. Overall pain reduction was greater with the mucoadhesive patches than with tablets. Diclofenac patches showed...
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Posted by admin on Apr 30, 2020 in |
The aim of the present study is to develop a stability-indicating reverse-phase high-performance liquid chromatography method for the simultaneous estimation of Aspirin and Dipyridamole in combined extended-release dosage form 25/200mg, using a single unit of the capsule. Materials and Methods: Chromatographic separation was achieved with Agilent’s high-performance liquid chromatography and X bridge C8 column, with the mobile phase containing a mixture of ammonium dihydrogen phosphate buffer (pH 2.5): methanol (550:450, v/v) by isocratic elution technique. The flow rate was maintained at 1.2 ml/min, and the detection wavelength was 230nm. Results: Aspirin and Dipyridamole were eluted at 4.7min and 12.6min, respectively, using the developed method. The method was linear in the range of 12.5-50μg/ml for Aspirin and 100-400 μg/ml for Dipyridamole, with an r2 value of 0.9997 and 0.9999, respectively. The sample recoveries observed were 97.63-100.96% and 97.38-98.01%, respectively, for aspirin and dipyridamole. The forced degradation studies were carried out, and the stressed samples were analyzed using the developed method. The purity angle of the peak was observed lesser than the...
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Posted by admin on Apr 30, 2020 in |
Alzheimer’s disease (AD) is a major type of dementia. AD is associated with memory impairment and cognitive deficit. It is characterized by low levels of acetylcholine in the brain of AD patients. The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the management of mild to moderate AD. In the present study, n-hexane, ethyl acetate, and hydroalcoholic leaf extracts of two medicinal plants Phyllanthus emblica (Euphorbiaceae) and Tamarindus indica (Fabaceae) were screened for anticholinesterase activity and compared with standard acetyl-cholinesterase inhibitor (galantamine) by Ellman’s spectrophotometric method. The results obtained from the three extracts of P. emblica and T. indica against AChE enzyme was evaluated for percentage inhibition and IC50 values. Among the extracts of P. emblica, ethyl acetate extract (96.62 ± 0.165) at a concentration of 200 µg/ml was found to be potent. Ethyl acetate extract of T. indica showed very potent inhibition (97.55 ± 0.087) at the concentration of 200 µg/ml and found to be equally potent with that of galantamine (98.63 ±...
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Posted by admin on Apr 30, 2020 in |
The RP-HPLC stability-indicating assay method has been developed and validated for the estimation of the amlodipine and chlorthalidone in bulk and combined dosage form. The method was optimized by using the mobile phase as a mixture of 0.1% formic acid: methanol: acetonitrile in the ratio of (50:5:45 v/v) at pH 3 was adjusted with orthophosphoric acid. The method was carried out on the Octadecylsilane C18 column (5 µm, 25 cm × 4.6 mm) using a flow rate of 1.0 ml per min. The method was scanned at λmax 266 nm for both the drugs using a PDA detector. The retention time was found to be at 6.32 min and 5.32 min for AML and CHL respectively. The calibration curve determined at respective retention time is found to be 2.5-7.5 μg/ml and 06-18 μg/ml with a regression coefficient of 0.9990 and 0.9940 for AML and CHL respectively. The developed and validated method is reliable, simple, precise and accurate and easy to apply in the...
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