Posted by admin on Jul 31, 2024 in |
Objectives: This observational cross-sectional study is aimed to assess the medication adherence and treatment satisfaction in hypertensive patients. This study was conducted at a public tertiary care hospital. Methods: Hypertensive patients of both the sex groups aged >60 years visiting outpatient department were enrolled. The Morisky Medication Adherence Scale and the Medication Interview Satisfaction Scale (MISS-21) were used to assess treatment adherence and satisfaction in the study population. The study included 153 hypertensive patients. Key findings: Most of the study participants had poor socioeconomic level and were in the age group of 60-65 years. The study participants reported high levels of treatment satisfaction. Patients reported good satisfaction across all four MISS domains: distress alleviation, communication comfort, compliance intent, and rapport. The frequency of nonadherence in this study was 24.2%. Conclusion: Despite reporting high levels of satisfaction, most patients did not adhere to their prescriptions. Aged hypertensive patients require special attention in hospitals to ensure proper treatment adherence. Patients with hypertension should be advised to take their medications for the...
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Posted by admin on Jul 31, 2024 in |
Plectranthus amboinicus, locally called Karpooravalli in Tamil Nadu, India, is known for its various traditional therapeutic properties. Rheumatoid arthritis is a chronic autoimmune disease where uncontrolled inflammatory markers are released to induce bone damage and pain. In this study, the methanolic extract of P. amboinicus was characterized phytochemically and subjected to in-silico analysis to evaluate its anti-inflammatory properties. The methanolic extract of P. amboinicus was subjected to gas chromatography-mass spectrometry (GCMS) analysis. The detected compounds were subjected to in-silico analysis with biomarkers specific for rheumatoid arthritis (RA) that is interleukin 6. Of the 86 profiled compounds, three belonging to flavonoid, porphyrin, and heterocyclic triazoles classification had the highest affinities for interleukin-6 and was compared with common DMARs given during RA treatment which had significantly low affinities to above 3 highest affinities bioactive compounds. The ADMET profile, drug-likeness, and bioactivity score were also calculated for all the GCMS profiled compounds, revealing adequate drug-like properties. In-silico analysis of the leaf extract of P. amboinicus compounds showed a promising result for its...
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Posted by admin on Jul 31, 2024 in |
Sweeteners are generally described in terms of their sweetness potencies relative to sucrose references. And, while caloric sweeteners have been found to have potencies invariant with sucrose reference concentration, noncaloric sweeteners decrease in potency as sucrose reference concentration increases. In this study, we develop methodology to determine the Concentration/Response functions for 9 (Omit “the”) noncaloric and 2 caloric sweeteners in water at room temperature. Two-Alternative Forced Choice methodology with a panel of 80 subjects was used to determine is sweet concentrations for these 11 sweeteners and multiple concentrations of sucrose. We found that the is sweetness data for all 8 of the high-potency noncaloric sweeteners are well modeled by the Law of Mass Action R = (Rm X C)/(Kd + C), where R is Response in % Sucrose Equivalents, Rm is Maximal Response in % Sucrose Equivalents, C is the sweetener Concentration in mg/L and Kd is the Concentration in mg/L resulting in Half-Maximal Response. We also found that the is sweetness data for the 2 caloric sweeteners Glucose...
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Posted by admin on Jul 31, 2024 in |
In the present investigation, sequentially extracted plant samples from T. catappa in water, methanol, ethanol and hexane were evaluated for COX-2 inhibitory activity. The in-vitro anti-inflammatory activity of selected samples showing promising COX-2 inhibition assessed using thermally induced protein denaturation assay. A total of nineteen compounds belonging to various phytochemical classes from T. catappa were selected (as initial hits) and screened against COX-2 enzyme using docking and drug-likeness/ADMET studies. From our studies, sixteen phytochemicals were identified as notable antiinflammatory agents (best hit molecules) with promising inhibitory effects effective against COX-2 enzyme. These compounds are namely, arjunolic acid, betulinic acid, ellagic acid, oleanolic acid, kaempferol, quercitin, leucocyanidin, gallic acid, arachidic acid, palmitic and stearic acid.On the basis of drug likeliness and binding studies of protein-ligand intercations. oleanolic acid, betulinic acid, ellagic acid, quercetin and ursolic acid were found to be the most potent (in-silico) COX-2 inhibitors. A validated rapid HPLC method was employed for the identification and quantification of phenols and flavonoid in plant sample. The present investigation can be directed towards further experimental studies in...
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Posted by admin on Jul 31, 2024 in |
We evaluated the antidyslipidemic activity of extract of Pterocarpus marsupium (PM: Vijayasar) in adult Charles Foster rats of both sexes and compared this activity with that that of Atorvastatin (Atorva). 4 groups were made [Gp 1- Control group (no drug), only high fat diet (HFD); Gp 2- HFD +PM (to evaluate the role of PM in the prevention of dyslipidemia); Gps 3 & 4- only HFD]. This was the phase of disease production [for 7 weeks] and preventive role of PM was also evaluated concurrently. Then, therapy phase started for next 90 days [Gp 1- Control group (no drug). Only HFD; Gp 3- HFD+ Atorva; Gp 4- HFD+ PM]. TC (total cholesterol), TG (triglycerides), LDL (low density lipoproteins) and HDL (high density lipoproteins) levels were tested. During both the phases (prevention and therapy), PM brought significant improvements in all these parameters. Therefore, Pterocarpus marsupium, as an economical herbal therapeutic approach; presents a cost-effective, secure and efficacious means to address significant public health issues; such as dyslipidaemia, coronary artery disease...
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