Posted by admin on Mar 31, 2020 in |
A number of strategies to deliver antifungal using nanocarriers are developed to facilitate drug targeting infected cells that result in improved antifungal activity. Objective: Ciclopirox olamine has a broad spectrum of action against dermatophytes, yeasts, filamentous fungi and bacteria. It has a biological half-life of 1.7 h and bioavailability of < 5% with prolonged use. A remarkable feature of the drug is that no single case of fungal resistance has been reported so far. Therefore, ciclopirox olamine loaded niosomes entrapped in suitable gel delivery systems may successfully deliver the drug for prolonged time in treatment of fungal infection. Material and Method: A Ciclopirox Olamine loaded niosomes were developed using various surfactants along with cholesterol in different proportions by ether injection and film hydration method. The prepared niosomes were evaluated for various characteristics such as shape and size, entrapment efficiency, in-vitro drug release studies. Result and Discussion: Among all, formulation CNFS61 showed optimal drug release with maximum entrapment efficiency having smaller vesicular size. So, formulation CNFS61 was considered as promising...
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Posted by admin on Mar 31, 2020 in |
Possibility of use of the informational parameters, which characterize adaptational and regenerative opportunities of organ, as potential criteria for the assessment of biological activity of tissue preparations, is investigated in this research. The influence of tissue preparation «STEMB» on the morphofunctional condition of a liver of rats at experimental toxic damage of organs was studied. The assessment of a morphofunctional condition of a liver under the influence of preparation was carried out as with use of traditional morphological, biochemical and histologic parameters, and also by means of informational parameters. A correlation analysis was conducted between the used biochemical, morphological and morphometric parameters and informational criteria. As a result of research it is established that hepatoprotective activity of preparation «STEMB» is confirmed both with results of traditional techniques of an assessment and with informational parameters, that allows drawing a conclusion on possibility of use of informational parameters as criterion of an estimation of biological activity of tissue...
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Posted by admin on Mar 31, 2020 in |
Munronia pinnata is a rare medicinal plant, naturally distributed in China, India, Vietnam, Indonesia, Malaysia, Philippines, and Sri Lanka. The entire plant is extensively used for medicinal purposes, especially for curing skin diseases and treating fever, including malaria. Four major ecotypes were identified in Sri Lanka that consist of 3, 5, 7, and 9 leaflets from various regions. This study was performed to investigate the phytochemical activity of four different ecotypes of Munronia. Leaves of ecotypes were collected and dried at 45 ºC for 15 h. The methanol extracts were prepared and used for screening of antioxidant activity, total polyphenol content, antifungal, and anti-diabetic activity. The findings were indicated that all ecotypes attest to significant differences in its activity but to varying degrees. The strongest antioxidant activity, highest polyphenol content, and mild inhibitory activity for Cladosporium cladosporioides were observed in ecotype with 3 leaflets. Ecotype with 7 and 9 leaflets showed moderate activity, and ecotype with 5 leaflets was the lowest for all tested properties. None of the ecotypes...
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Posted by admin on Mar 31, 2020 in |
Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an important role in cellular localization, enzyme stability. The target enzyme for Staphylococcus aureus was studied and retrieved from PDB. The bioactive compounds from the leaf extract of Rhizopora mucornata was screened for Lipinski rule of Five and ADMET properties. Autodock 4.2.3 software was used for molecular docking, and the visualization was done by using discovery studio 3.1. Result: The compound 3-methyl-2-(2-oxopropyl) furan shows better binding energy with -1.14 Kcal/mol against the enzyme protein tyrosine phosphatase followed by 3-cyclopentylpropionic acid, 4-methoxyphenyl ester +35.14 Kcal/mol. The hydrogen interactions and Vander Waals interactions, along with total residues of amino acids were studied. This research mainly focuses on targeting the virulent enzyme by using potential drugs to discover...
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Posted by admin on Mar 31, 2020 in |
This was a 24-week, randomized, open label study. Treatment-naive patients diagnosed with Type 2 diabetes mellitus were randomized into two groups, Group-1 (Vildagliptin 50 mg, twice dailyplus Metformin 500 mg, twice daily) and Group-2 (Teneligliptin 20 mg, once dailyplus Metformin 500 mg, twice daily). The primary objective was to compare fasting plasma blood glucose levels (FBG), 2-h post prandial blood glucose levels (2-h PPG) and HbA1c reduction from baseline in both the groups at the week 24 endpoint. From comparable baseline values HbA1c decreased in both treatment groups, to the greater extent with teneligliptin plus metformin combination therapy. Reductions in FPG were superior with teneligliptin plus metformin combination therapy [change from baseline -38.63 mg/dL] (p>0.05). Reductions in 2-h PPG were also superior with teneligliptin plus metformin combination therapy [change from baseline -37.85 mg/dL] (p>0.05). There was no incidence of hypoglycemia with either combination therapy. Efficacy and Safety of Teneligliptin over a period of 24 weeks was comparable to that of vildagliptin when given with stable doses of...
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