Posted by admin on May 31, 2020 in |
In view of the biological prominence of the benzoxazole derivatives as well as, isatin derivatives, it was planned to synthesize some novel N-(Benzoxazol-2-yl)-2-(2-oxoindolin-3-ylidine) hydrazine carbothioamides (VI) as such reports were not available in the literature and were screened for antibacterial, antifungal and anti-mycobacterial activity. Fourteen new compounds were synthesized by condensing different Isatins (V) with N-(Benzoxazol-2-yl) hydrazine carbothioamide (IV). All the prepared compounds were screened for antibacterial, antifungal, and antimycobacterial activities on various microbial strains. The results revealed that all the synthesized compounds were exhibiting antimicrobial properties. Compound VIc, VIe, VIg, VIi, and VIl were declared to possess potent antimicrobial properties in the given bacterial and fungal...
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Posted by admin on Apr 30, 2020 in |
A simple, selective, precise, and stability-indicating RP-HPLC method has been developed for the determination of Curcumin in bulk forms and solid dosage formulations. The HPLC separation was achieved on Waters Spherisorb ODS2 column (4.6mm × 250mm, 5µm particle size) using a mobile phase of methanol-water (77:33 v/v, pH 3) at a flow rate of 1ml/min and spectrophotometric detection at 419 nm. The method was validated for specificity, linearity, accuracy, precision, solution stability, robustness, system suitability, and ruggedness. The detector response for the Curcumin was linear over the selected concentration range from 1 to 10 µg/ml, with a correlation coefficient of 0.9993. The accuracy was between 99.27& 101.97%. The precision (R.S.D.) among the six sample preparations was 1.27%. The LOD and LOQ are 0.092 and 0.278 µg/ml, respectively. The recovery of curcumin was about 100.12%. The drug was subjected to acid and alkali hydrolysis, oxidation, wet heat treatment, and photodegradation. The drug undergoes degradation under former conditions, which indicates that the drug is susceptible to acid and base hydrolysis, wet...
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Posted by admin on Apr 30, 2020 in |
Studies have confirmed the medicinal potential of the Leea macrophylla mentioned in traditional medicine. While the effects of the Leea macrophylla extract on some bacteria and Brine shrimp lethality using their different concentrations has not been previously explored. The present study shows that the standardized aqueous and ethanolic extract of Leea macrophylla exhibited antibacterial and cytotoxic activity. The findings of the present work provide promise for the development of new molecules of treat microbial infections and...
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Posted by admin on Apr 30, 2020 in |
The present study describes simple, accurate, precise and cost effective UV-spectroscopic method for the estimation of clomiphene citrate in methanol as per ICH guidelines. The absorption maxima for clomiphene citrate in methanol was found to be 235nm and 294 nm. The drug follows linearity (linearity 1, linearity 2 & linearity 3) in the concentration range 3-40 μg/ml at 294 nm and 3-24 μg/ml at 235 nm with a correlation coefficient value of 0.9991, 0.9989, 0.9988 and 0.999, 0.9994, 0.9994 respectively. The accuracy of the method was checked by recovery experiment performed at three levels i.e., 80%, 100%, 120%. The percent recovery was found to be in the range of 90-120%. The low values of % RSD are indicative of accuracy and reproducibility of method. The % RSD <2 indicates that method is precise. The ruggedness of method was studied with the help of different analysts. No significant degradation of clomiphene citrate was showed in force degradation studies like heat-induced degradation the spectra for acid degradation, acid/base hydrolysis, oxidation and...
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Posted by admin on Apr 30, 2020 in |
The main aim of this work was to formulate and study mucoadhesive buccal tablets of valsartan using various suitable bioadhesive polymers such as CP 934 and Xanthan gum. Nine formulations of valsartan were prepared by the direct compression method. The prepared tablets were characterized by swelling studies, % matrix erosion, surface pH, bioadhesive properties, in-vitro drug dissolution and in-vitro diffusion studies. It was found that CP 934 increases the swelling index also increased. The surface pH of all formulations was found to be satisfactory, and values were in between the range of 5-7 pH, hence no irritation to the buccal cavity is assumed. Tablets containing CP: Xanthan gum in the ratio 3:1 has shown the maximum percentage of in-vitro drug release through the buccal mucosa. The drug release was found to be zero-order release. The formulation F3 was considered as the optimized formulation based on satisfactory bioadhesive strength, in-vitro dissolution drug release of 96.72 ± 0.43%, for 12...
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