Posted by admin on Feb 29, 2020 in |
Rheological properties of carboxymethyl locust bean gum (CMLBG) solutions having different concentrations and solution pH were evaluated through steady shear and oscillatory measurements and were used to describe the erosion propensity of CMLBG coat of compression coated placebo tablets. CMLBG solutions, irrespective of concentration and solution pH, exhibited predominant viscous character as the viscous modulus (G”)> elastic modulus (G’) and phase angle (Tan δ) > 1. The viscous contribution was found to be influenced by both the CMLBG concentration and solution pH. An increase in CMLBG concentration increased the pseudo-plasticity and consistency coefficient and decreased the viscous contribution in all solution pH resulting in a decrease in erosion of CMLBG coat. The higher viscous character of CMLBG in buffer solution of pH 7.4 (Solution B) was responsible for higher erosion of the coat than in acid solution of pH 1.2 (Solution A). When the pH of acid solution of CMLBG was increased dynamically from 1.2 to 7.4, the viscous contribution decreased to some extent than that observed in Solution...
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Posted by admin on Feb 29, 2020 in |
Cold and hot methanolic extract of leaves and whole plant parts of Andrographis paniculata were tested against gram-negative Escherichia coli (MTCC 1679) Klebsiella pneumonia (MTCC 4032) Streptococcus pyogenes, Solmonella typhimurium (MTCC733) and gram-positive Staphylococcus aureus (MTCC737). Maximum activity among all the bacterial cultures tested was showed against E. coli MTCC1679 when compared with their standards. Next to E. coli, MTCC1679 best inhibition was seen against S. aureus (MTCC737). There was no inhibition reported against, K. pneumonia, S. pyogenes, Salmonella typhi. The studied result revealed the highest activity in 75% methanolic extract. The highest zone of inhibition (22 mm) was observed against E. coli at a dose of 3.0 mg. The antibacterial activities of 75% methanol extract from A. paniculata leaves were observed only against the E. coli. The extract was not found active against other tested bacterial pathogens. The Andrographolide compound was analyzed by HPLC chromatogram and the standard of the given andrographolide compound was also prepared by the...
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Posted by admin on Feb 29, 2020 in |
A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gram-negative bacteria. Green synthesis of nanoparticles offers minimization of wastage, reduction of derivatives, use of non-toxic solvent, auxiliaries and renewable feedstock. A single step, an eco- friendly, cost-effective method is used for the synthesis of copper nanoparticles (CuNPs) from 1.0 mM copper sulphate solution using extract of Ocimum sanctum (Tulsi) leaves as reducing and capping agent. UV-VIS, FESEM, FTIR and XRD were used to confirm and characterize the NPs. The biosynthesized copper NPs were phased pure and well crystalline with a simple cubic structure. Antibacterial study of the biogenic CuNPs suggests their efficacy against common human bacterial pathogen species. Gram-negative test organisms were found to be more susceptible to toxicity of biosynthesized CuNPs. Metal nanoparticles hold the...
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Posted by admin on Feb 29, 2020 in |
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control in people with type 2 diabetes. In this study, we have fabricated a Solid-State Lipid-Based Oral Drug Delivery System as CNZ SLH with liquid lipids like Miglyol 812, Labrasol and Acrysol el 135. Sylloid 244 FP grade highly porous silica was used as adsorbent. The interaction of CNZ-SLH particles was studied using X-ray powder diffraction (PXRD), Differential Scanning Calorimetry (DSC) and FTIR spectroscopy. CNZ-SLH particles prepared with Miglyol and Labrasol enhanced the solubility of CNZ by 19.67 fold. Optimized SLH particles formulated as a tablet shows faster drug release than the marketed formulation of CNZ Invokana. Silica lipid hybrid particles can be a cost-effective method to formulate drugs with poor...
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Posted by admin on Jan 31, 2020 in |
Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The various parts of Euphorbia antiquorum have been associated with a number of pharmacological activities which are cytotoxic, hepato-protective and antioxidant. The juice of the plant is acrid, anti-inflammatory, purgative and is useful in rheumatism, dropsy, gout, neuropathy, deafness, cough. The aim of the study was to evaluate the effects of Euphorbia antiquorum on alloxan induced diabetic nephropathy in Wistar rats. Experimental diabetic nephropathy was induced by a single intraperitoneal (i.p) administration of alloxan 120 mg/kg body weight (b.w.). Wistar rats were randomly divided into normal control, diabetic control, diabetic control with standard drug and diabetic treated with ethanolic extract of Euphorbia antiquorum at 200 and 400 mg/kg doses respectively. The...
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