Posted by admin on Mar 31, 2020 in |
Lornoxicam has been found to be not interacted by eperisone hydrochloride at 377 nm. Therefore, it is estimated directly as a single component in the mixture, whereas eperisone hydrochloride is throughout interfered with by lornoxicam in UV region. So, it was estimated in the mixture using a two-wavelength difference method. Lornoxicam was found to have same absorbance at 262 nm and 283 nm but not eperisone hydrochloride. So, a difference in absorbance of the mixture at 262 nm and 283 nm was directly proportional to the concentration of eperisone hydrochloride. The calibration curves were validated according to ICH guidelines and were linear over the concentration range tested (10-20 µg/ml for lonoxicam and 3-24 µg/ml for eperisone hydrochloride). The curves were found to be precise and accurate as shown by acceptable limits of %RSD (0.37%-0.66%) and percent recoveries (98.73% ± 1.02%-102.44% ± 0.90%) respectively for both the drugs in mixture as well as in pure...
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Posted by admin on Mar 31, 2020 in |
The purpose of this study was to develop a gastroretentive controlled release drug delivery system using sintering for enhanced oral bioavailability using carnauba wax polymer. Formulations (CC1-CC3) were prepared by wet granulation method and then exposed to sintering temperature at different time intervals. The optimized formula showed zero-order drug release kinetics for the period of 12 h. The results revealed that sintering temperature and time of exposure significantly affected the in-vitro drug release and floating character. FTIR Spectra showed no noticeable incompatibility between drug and polymers in both physical mixtures and in the...
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Posted by admin on Mar 31, 2020 in |
HPTLC is a simple, rapid, precise and accurate method with densitometric detection for the determination of beta-sitosterol in a Pergularia daemia Forsk. Petroleum ether and methanol extract of the leaf and stem were powder and used for the experimental work. The separation was performed on silica gel 60 F254 HPTLC plates with Toluene: Ethyl acetate (80:20 v/v), as the mobile phase. The determination was carried out using the densitometric absorbance mode at 690 nm. β-sitosterol response was linear over the range of 100-1000µg/ml, with a correlation coefficient is 0.999. Intraday and interday precision studies showed the relative SD was 0.027. The accuracy of the method was determined, and the average recovery was 99.92%.The limit of quantitation and limit of detection were 8 and 4 mg/ml, respectively. The percentage of beta-sitosterol was found to be 22.16% w/w in unsaponifiable matter of leaf, 33.05% unsaponifiable matter of stem w/w 2.49% w/w petroleum ether extract of leaf 3.28% w/w petroleum ether extract of stem. The method was evaluated for sensitivity, accuracy, precision,...
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Posted by admin on Mar 31, 2020 in |
Free radicals are responsible for the development of many diseases. Anti-oxidants play an important role in scavenging free radicals. Anti-oxidant activity of herbal extracts and isolated compounds are reported earlier. Pharmaceutical industries are carrying out research in the development of new potent antioxidants. Novel drug development from economically cheapest plant waste might be useful for many pharmaceutical industries. Tender coconut mesocarp (TCM) is one of the cheapest plant materials used by coir industry etc. Aim of the present study is to analyses various phytochemicals present in the hydroalcoholic extract of TCM and evaluate its antioxidant activity in the in-vitro condition. Qualitative analysis of phytoconstituents present in hydroalcoholic extract (HAE) of TCM shows the presence of carbohydrate, phenolic compounds, flavonoids and tannin. Quantitative analysis of phytoconstituents in HAE shows the remarkable amount of phenols, flavonoids, tannin and vitamin C. LCMS analysis of HAE shows the presence of (±) 13-Azaprostanoic acid with maximum ppm (13.58) and 14 other compounds with ppm > 3n were identified. The IC50 value of HAE to...
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Posted by admin on Mar 31, 2020 in |
Introduction: The aim of the present study is to formulate and evaluate the simvastatin chronopharmaceutical delivery system using a novel coating method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h. Observation: Simvastatin is a hyperlipidemia drug that inhibit the synthesis of cholesterol by inhibiting the HMG-COA reductase enzyme. Experiment: The basic design of the system consists of a rapid release core and a controlled release coat. The powder blend was evaluated for the angle of repose, Carr’s index, Hausner ratio, and compressibility index. The core tablet was evaluated for in-vitro release. The coated tablet was evaluated for weight variation, hardness, thickness, friability, disintegration, in-vitro dissolution, in-vitro comparative study, acid uptake test, rupture test, swelling studies, SEM, stability studies and FTIR, etc. Results and Discussion: The preformulation studies were revealed compatible results, and the rupture time, swelling time, acid uptake study showed satisfactory results by which it indicates the core molecule will be released at a prominent...
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