Posted by admin on Jan 31, 2020 in |
During the past few years many phytochemicals responsible for anti-diabetic effects have been isolated from the plants. Several phyto-constituents such as alkaloids, glycosides, flavonoids, saponins, dietary fibers, polysaccharides, glycolipids, peptidoglycans, amino acids and others obtained from various plant sources that have been reported as potent hypoglycemic agents. In the present study, the effect of methanolic extract of whole plant of Lindernia ciliata (LCME) (100, 200 and 400 mg/kg) on glucose levels in streptozotocin (STZ) (45 mg/kg) induced diabetic rats was investigated using glibenclamide 10 mg/kg as the positive control. The effect of the extract on body weight, insulin, total cholesterol, triglycerides, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), total protein, serum urea, creatinine and hematological indices in normal, treated and untreated diabetic rats was investigated. Induction of diabetes in male Wistar rats (200-250 g) resulted in increased levels of serum glucose, total cholesterol, triglycerides, SGOT, SGPT, ALP, urea and creatinine and decreased bodyweight, serum insulin, total protein, RBC, WBC and hemoglobin levels. Administration...
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Posted by admin on Jan 31, 2020 in |
Changes in the hemolymph protein and trehalose contents of the silkworm, Bombyx mori L. due to Streptococcus mutans infection and antibiotics treatment was evaluated. Interestingly, S. mutans, which was successfully grown in the body of the larvae led to decline 69.60 and 50.21% of protein content in the hemolymph. Concomitantly, there was a drastic rise in the content of trehalose to 60.22 and 65.13% due to bacterial infection-induced through hemocoel and oral routes respectively compared to healthy larval batches. Antibiotics clinically advocated to cure dental caries was substantially lowered the bacterial infection in the silkworm larvae regulating a rise in the protein and reduction in the trehalose contents. Notably, antibiotic-Advent treatment through hemocoel and oral routes explicit higher rate of recovery in the synthesis of protein that amounts to 133.79 and 92.62%, while trehalose content was found 34.30 and 40.31% less in the hemolymph that equivalent to healthy larvae respectively. Similarly, taxim was also influenced for an elevation of protein content 106.73 and 78.99%, whereas there was a reduction...
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Posted by admin on Jan 31, 2020 in |
Hepatotoxicity in the form of acute liver failure is a serious side effect of several drugs most importantly paracetamol. Beetroot main ingredients are nitrate, betalains, phenolics and ascorbic acid, which are responsible for its protective against oxidative stress and inflammation. Aim: This study assessed the possible protective effect of beetroot against liver toxicity induced by paracetamol. Method: Forty adult male rats where divided into four groups (ten/each): control groups, group I and II (with and without beetroot juice), group III, paracetamol treated group (400 mg/kg/day), and group IV protected group (paracetamol concomitant with beetroot juice by gavage 2 ml/day) for one month. Blood samples and liver tissues were collected and subjected to biochemical and microscopic analysis, respectively. Results: Results demonstrated that paracetamol consumption, group III, induced toxicity to the liver evident by high ALT and AST. The intake of beetroot juice concomitantly with paracetamol (group IV) ameliorates its side effects supported by histological findings and liver function chemistry results. Group IV showed a decreased ALT and AST levels to...
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Posted by admin on Jan 31, 2020 in |
Ammoniacum gum is traditionally used as an expectorant, stimulant, antispasmodic, catarrh, asthma, chronic bronchitis, and enlargement of liver and spleen in Medicine. The Soxhlet extraction of the oleo gum resin of D. ammoniacum was carried out with organic solvents including hexane, dichloromethane, chloroform, ethyl acetate, and methanol. The screening of the anti-alzheimer activity of the extracts was measured by acetylcholinesterase (AChE) inhibitory activity, and the hexane (IC50 = 32.34 μg/ml) and chloroform (IC50 = 43.5 μg/ml) extract performed highest activity. A profiling experiment of the chloroform extract conducted by LC-MS and literature resources suggested six potential biologically active compounds including doremone A (1), kopetdaghin E (2), dshamirone (3), kopetdaghin D (4), kopetdaghin C (5), and ammodoremine (6). To confirm the responsibility of these compounds for the observed AChE inhibitory activity, the molecular docking studies of these compounds were performed with AChE enzyme which indicated that these compounds show higher AChE inhibitory activity than galantamine as positive control. The molecular docking study was carried out using...
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Posted by admin on Jan 31, 2020 in |
The global burden of CVD is rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The present study was aimed to investigate the potential antihyperlipidemic activity of ethanolic leaf extract of Bauhinia acuminata in atherogenic diet-induced rats. Preliminary phytochemical screening showed the presence of flavonoids, alkaloids, steroids, terpenoids. Acute toxicity study was performed on the rats using OECD Guideline no. 423 and the maximum safe dose was found to be 5000 mg/kg. Animals were grouped into normal control (Group-I), disease control (Group-II), standard group (Group-III) received Standard drug Atorvastatin 10 mg/kg, and test group (Group-IV) received ethanolic extract of the plant with doses 200 mg/kg and 400 mg/kg. The study was conducted for 30 days and hyperlipidemia induced using atherogenic diet. Statistical analysis was performed using Graph Pad Prism and the values are expressed as mean ± SD values. Bodyweight changes were observed every day upon Induction of...
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